Metabolic Havoc of Uncontrolled Diabetes
The metabolic havoc arising out of altered physiology of tissues leads to a continuously existing diabetic state. Basic defects have already occurred, and whether the glucose control is excellent or poor, the balance of actions between various organs, hormones, and fuels is always precarious as it can destabilize at the slightest provocation. Over a period of years, diabetes does initially cause functional as well as structural alterations later in organs and tissues. Thus there are the cumulative effects of years of being in diabetic state. These changes reach a stage of such deterioration that managing life becomes difficult. It must also be understood that diabetic state begins years before the actual diagnosis of diabetes is or can be made. IGT is a precursor of diabetes and exemplifies the diabetic state in organs, tissues, hormones, and fuel statuses. It is also widely believed that diabetic state on an average starts about 5–7 years in type 2 diabetes before diagnosis.
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