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Profilin: The Associates of Formin

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Book cover Actin Polymerization in Apicomplexan

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Abstract

Profilin (13–20 kDa) is an actin-sequestering protein specializing in maintenance of actin into proto-filamentous form. In this chapter, we discuss the role of profilin in actin elongation and its association with the formin protein. In order to understand the function of profilin in relation to its structure, we studied the sequence and structure of the protein. This chapter also discusses different binding partners of profilin to better understand its role in actin polymerization and in turn the gliding motility in apicomplexan. We also talk about the apicomplexan-specific mini-domain present in profilin in order to deduce the functional aspect of these domains. Apart from discussing the actin-profilin and actin-formin interactions from structure-function perspective, we also report various regulatory proteins of profilin.

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Authors and Affiliations

  1. School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS), Mumbai, Maharashtra, India

    Samridhi Pathak, Ricka Gauba & Avinash Kale

  2. Department of Computer Science, Synthetic Biology Theme, Brunel University London, Uxbridge, UK

    Sarath Chandra Dantu

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  1. Samridhi Pathak
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  1. School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS), Mumbai, Maharashtra, India

    Avinash Kale

4.1 Supplementary Electronic Material (S)

ST_PRF-1

Sequence comparison identity matrix for profilin proteins used in the current study (XLSX 70 kb)

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Pathak, S., Gauba, R., Dantu, S.C., Kale, A. (2019). Profilin: The Associates of Formin. In: Kale, A. (eds) Actin Polymerization in Apicomplexan. Springer, Singapore. https://doi.org/10.1007/978-981-13-7450-0_4

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