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Recent Insights on the Anticancer Properties of Flavonoids: Prospective Candidates for Cancer Chemoprevention and Therapy

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Natural Bio-active Compounds

Abstract

Flavonoids are polyphenolic compounds of very important class of plant secondary metabolites having a broad spectrum of biological activities. Because of their antioxidative, anti-inflammatory, antimutagenic, and anticarcinogenic properties, flavonoids have become an indispensable component in nutraceuticals, pharmaceuticals, medicinal, and cosmetic applications. The bioavailability, metabolism, and biological activities of many flavonoids have drawn the attention of researchers to use them as an alternative source of therapeutics for the treatment of various diseases; flavonoids have been shown to disrupt the initiation, promotion, and progression of cancer by modulating various signaling pathways and their downstream components associated with cellular proliferation, differentiation, inflammation, apoptosis, metastasis, angiogenesis, and reversal of multidrug resistance. Many natural flavonoids and their synthetic analogs are being investigated for their potential applications in anticancer therapies, because of their multi-targeted mechanism of action. Thus, the aim of the present chapter is to highlight the new insights on the recent progress of flavonoids as effective candidates in cancer therapeutics and prevention.

Irfan A. Ansari and Mohd Sayeed Akhtar have equally contributed for this chapter.

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    Authors and Affiliations

    1. Department of Biosciences, Integral University, Lucknow, Uttar Pradesh, India

      Irfan A. Ansari

    2. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

      Mohd Sayeed Akhtar

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    1. Irfan A. Ansari
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    2. Mohd Sayeed Akhtar
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    Correspondence to Irfan A. Ansari .

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    1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

      Mohd Sayeed Akhtar

    2. Department of Biotechnology, East West First Grade College of Science, Bengaluru, Karnataka, India

      Mallappa Kumara Swamy

    3. Department of Crop Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

      Uma Rani Sinniah

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    Ansari, I.A., Akhtar, M.S. (2019). Recent Insights on the Anticancer Properties of Flavonoids: Prospective Candidates for Cancer Chemoprevention and Therapy. In: Akhtar, M., Swamy, M., Sinniah, U. (eds) Natural Bio-active Compounds. Springer, Singapore. https://doi.org/10.1007/978-981-13-7154-7_13

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