Abstract
Chronic obstructive pulmonary disease (COPD) and asthma are the most common inflammatory respiratory diseases related to an increase in mortality and morbidity. Generally, bronchodilators, ß- agonists, anticholinergics and theophylline used for treatment in these conditions and administered by inhalation for delivery, have localized and systematic effects. The adverse effects are due to pharmacodynamic and pharmacokinetic changes and especially drug-drug and drug-disease interactions. However, phytotherapy is classical and widespread throughout the world for the treatment of ailments. This chapter highlights cellular and molecular mediators involved in COPD and asthma, the shortcomings of current therapies and the emerging need of phytomedicines. Phytomedicine supports respiratory physiology, bronchial action and possesses antioxidants to maintain homeostasis.
Keywords
- Phytomedicine
- Inflammatory diseases
- Chronic obstructive pulmonary disease
- Asthma
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References
Agustí A, Celli B. Natural history of COPD: gaps and opportunities. ERJ Open Res. 2017;3(4). https://doi.org/10.1183/23120541.00117-2017.
Asher I, Pearce N. Global burden of asthma among children. Int J Tuberc Lung Dis. 2014;18(11):1269–78.
Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM. The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am J Respir Crit Care Med. 2011;183(7):876–84. https://doi.org/10.1164/rccm.201005-0718OC.
Barisione G, Baroffio M, Crimi E, Brusasco V. Beta-adrenergic agonists. Pharmaceuticals. 2010;3(4):1016–44.
Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci. 1998;94(6):557–72.
Barnes PJ. New concepts in chronic obstructive pulmonary disease. Annu Rev Med. 2003;54(1):113–29.
Barnes PJ. Chronic obstructive pulmonary disease: a growing but neglected global epidemic. PLoS Med. 2007;4(5):e112. https://doi.org/10.1371/journal.pmed.0040112.
Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008;8:183. https://doi.org/10.1038/nri2254.
Barnes PJ. Similarities and differences in inflammatory mechanisms of asthma and COPD. Breathe. 2011;7(3):229–38. https://doi.org/10.1183/20734735.026410.
Barnes PJ, Shapiro S, Pauwels R. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J. 2003;22(4):672–88.
Barnes PJ, Drazen JM, Rennard SI, Thomson NC. Asthma and COPD: basic mechanisms and clinical management. Amsterdam: Elsevier; 2009.
Barr RG, Rowe BH, Camargo CA. Methylxanthines for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2003; 2: CD002168. https://doi.org/10.1002/14651858.CD002168.
Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM, Gibson P, Ohta K, O’Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31(1):143–78. https://doi.org/10.1183/09031936.00138707.
Bender BG. Overcoming barriers to nonadherence in asthma treatment. J Allergy Clin Immunol. 2002;109(6):S554–9.
Boukhenouna S, Wilson MA, Bahmed K, Kosmider B. Reactive oxygen species in chronic obstructive pulmonary disease. Oxidative Med Cell Longev. 2018;2018:5730395. https://doi.org/10.1155/2018/5730395.
Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med. 2002;346(22):1699–705. https://doi.org/10.1056/NEJMoa012705.
Brooks CR, van Dalen CJ, Hermans IF, Gibson PG, Simpson JL, Douwes J. Sputum basophils are increased in eosinophilic asthma compared with non-eosinophilic asthma phenotypes. Allergy. 2017;72(10):1583–6. https://doi.org/10.1111/all.13185.
Comer DM, Kidney JC, Ennis M, Elborn JS. Airway epithelial cell apoptosis and inflammation in COPD, smokers and nonsmokers. Eur Respir J. 2013;41(5):1058–67. https://doi.org/10.1183/09031936.00063112.
Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med. 2009;360(23):2445–54. https://doi.org/10.1056/NEJMra0804752.
Cruz AA. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. Geneva: World Health Organization; 2007.
Cukic V, Lovre V, Dragisic D, Ustamujic A. Asthma and chronic obstructive pulmonary disease (COPD) – differences and similarities. Mater Sociomed. 2012;24(2):100–5. https://doi.org/10.5455/msm.2012.24.100-105.
Davies DE. The role of the epithelium in airway remodeling in asthma. Proc Am Thorac Soc. 2009;6(8):678–82.
De Vries F, Bracke M, Leufkens HG, Lammers JWJ, Cooper C, Van Staa TP. Fracture risk with intermittent high-dose oral glucocorticoid therapy. Arthritis Rheum. 2007;56(1):208–14.
Divekar R, Kita H. Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation. Curr Opin Allergy Clin Immunol. 2015;15(1):98–103. https://doi.org/10.1097/aci.0000000000000133.
Eapen MS, Hansbro PM, McAlinden K, Kim RY, Ward C, Hackett TL, Walters EH, Sohal SS. Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD). Sci Rep. 2017;7(1):13392. https://doi.org/10.1038/s41598-017-13888-x.
Fischer BM, Voynow JA. Neutrophil elastase induces MUC 5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am J Respir Cell Mol Biol. 2002;26(4):447–52.
Foster PS, Rosenberg HF, Asquith KL, Kumar RK. Targeting eosinophils in asthma. Curr Mol Med. 2008;8(6):585–90.
Freeman L, Lawlis G. Exercise as an alternative therapy. Mosby’s complementary and alternative medicine: a research-based approach. 2nd ed. St Louis: Mosby; 2004. p. 481–518.
GOLD. Global initiative for chronic obstructive lung disease-global strategy for the diagnosis, management, and prevention of COPD. 2019.
Gross NJ. Anticholinergic agents in asthma and COPD. Eur J Pharmacol. 2006;533(1–3):36–9.
Gupta P, O’Mahony MS. Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people. Drugs Aging. 2008;25(5):415–43.
Hamilton WL, Doyle C, Halliwell-Ewen M, Lambert G. Public health interventions to protect against falsified medicines: a systematic review of international, national and local policies. Health Policy Plan. 2016;31(10):1448–66.
Ihn H. Pathogenesis of fibrosis: role of TGF-β and CTGF. Curr Opin Rheumatol. 2002;14(6):681–5.
Ismail I, Chan S. Knowledge and practice of complementary medicine amongst public primary care clinic doctors in Kinta district, Perak. Med J Malaysia. 2004;59(1):4–10.
Ito K, Watanabe S, Kharitonov S, Hanazawa T, Adcock I, Barnes P. Histone deacetylase activity and gene expression in COPD patients. Eur Respir J. 2001;18:316S.
Kaplan AG, Balter MS, Bell AD, Kim H, McIvor RA. Diagnosis of asthma in adults. CMAJ Can Med Ass J. 2009;181(10):E210–20. https://doi.org/10.1503/cmaj.080006.
Kay AB, Menzies-Gow A. Eosinophils and interleukin-5: the debate continues. Am J Respir Crit Care Med. 2003;167:1586–7.
Kayne SB. Complementary therapies for pharmacists. London: Pharmaceutical Press; 2002.
Kendall DE. National Center for Complementary and Alternative Medicine (NCCAM) introduction to acupuncture with disclaimer. Schweiz Z Ganzheitsmedizin Swiss J Integr Med. 2013;25(4):241–6.
King PT. Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer. Clin Transl Med. 2015;4(1):68. https://doi.org/10.1186/s40169-015-0068-z.
Koo HK, Vasilescu DM, Booth S, Hsieh A, Katsamenis OL, Fishbane N, Elliott WM, Kirby M, Lackie P, Sinclair I, Warner JA, Cooper JD, Coxson HO, Pare PD, Hogg JC, Hackett TL. Small airways disease in mild and moderate chronic obstructive pulmonary disease: a cross-sectional study. Lancet Respir Med. 2018;6(8):591–602. https://doi.org/10.1016/s2213-2600(18)30196-6.
Korosec P, Gibbs BF, Rijavec M, Custovic A, Turner PJ. Important and specific role for basophils in acute allergic reactions. Clin Exp Allergy. 2018;48(5):502–12. https://doi.org/10.1111/cea.13117.
Laidlaw TM, Boyce JA. Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin Exp Allergy. 2012;42(9):1313–20. https://doi.org/10.1111/j.1365-2222.2012.03982.x.
Larsson K. Aspects on pathophysiological mechanisms in COPD. J Intern Med. 2007;262(3):311–40.
Lee I-T, Yang C-M. Inflammatory signalings involved in airway and pulmonary diseases. Mediat Inflamm. 2013;2013:12. https://doi.org/10.1155/2013/791231.
Lee H, Kim Y, Kim HJ, Park S, Jang YP, Jung S, Jung H, Bae H. Herbal formula, PM014, attenuates lung inflammation in a murine model of chronic obstructive pulmonary disease. Evid Based Complement Alternat Med: eCAM. 2012;2012:769830. https://doi.org/10.1155/2012/769830.
Lee JW, Shin NR, Park JW, Park SY, Kwon OK, Lee HS, Hee Kim J, Lee HJ, Lee J, Zhang ZY, Oh SR, Ahn KS. Callicarpa japonica Thunb. attenuates cigarette smoke-induced neutrophil inflammation and mucus secretion. J Ethnopharmacol. 2015;175:1–8. https://doi.org/10.1016/j.jep.2015.08.056.
Liu T, Wu J, Zhao J, Wang J, Zhang Y, Liu L, Cao L, Liu Y, Dong L. Type 2 innate lymphoid cells: a novel biomarker of eosinophilic airway inflammation in patients with mild to moderate asthma. Respir Med. 2015;109(11):1391–6. https://doi.org/10.1016/j.rmed.2015.09.016.
Lomas DA. Does protease-antiprotease imbalance explain chronic obstructive pulmonary disease? Ann Am Thorac Soc. 2016;13(Suppl 2):S130–7. https://doi.org/10.1513/AnnalsATS.201504-196KV.
Masala S, Magrini A, Taglieri A, Nano G, Chiaravalloti A, Calabria E, Di Trapano R, Pietroiusti A, Simonetti G. Chronic obstructive pulmonary disease (COPD) patients with osteoporotic vertebral compression fractures (OVCFs): improvement of pulmonary function after percutaneous vertebroplasty (VTP). Eur Radiol. 2014;24(7):1577–85.
May SM, Li JTC. Burden of chronic obstructive pulmonary disease: healthcare costs and beyond. Allergy Asthma Proc. 2015;36(1):4–10. https://doi.org/10.2500/aap.2015.36.3812.
McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56(2):163–84.
Merican I. Traditional/complementary medicine: the way ahead. Med J Malays. 2002;57(3):261–5.
Mitchell PD, O’Byrne PM. Epithelial-derived cytokines in asthma. Chest. 2017;151(6):1338–44. https://doi.org/10.1016/j.chest.2016.10.042.
Montuschi P. Pharmacological treatment of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2006;1(4):409–23.
Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145–73. https://doi.org/10.1146/annurev.iy.07.040189.001045.
Nahin RL, Dahlhamer JM, Stussman BJ. Health need and the use of alternative medicine among adults who do not use conventional medicine. BMC Health Serv Res. 2010;10(1):220.
Niedzwiecki A, Roomi MW, Kalinovsky T, Rath M. Anticancer efficacy of polyphenols and their combinations. Nutrients. 2016;8(9):552. https://doi.org/10.3390/nu8090552.
Nowak D, Kasielski M, Antczak A, Pietras T, Bialasiewicz P. Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking. Respir Med. 1999;93(6):389–96.
O’Donnell R, Breen D, Wilson S, Djukanovic R. Inflammatory cells in the airways in COPD. Thorax. 2006;61(5):448–54. https://doi.org/10.1136/thx.2004.024463.
Ohno I, Nitta Y, Yamauchi K, Hoshi H, Honma M, Woolley K, O’Byrne P, Dolovich J, Jordana M, Tamura G. Eosinophils as a potential source of platelet-derived growth factor B-chain (PDGF-B) in nasal polyposis and bronchial asthma. Am J Respir Cell Mol Biol. 1995;13(6):639–47.
Pabreja K, Gibson P, Lochrin AJ, Wood L, Baines KJ, Simpson JL. Sputum colour can identify patients with neutrophilic inflammation in asthma. BMJ Open Respir Res. 2017;4(1):e000236. https://doi.org/10.1136/bmjresp-2017-000236.
Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5:e47. https://doi.org/10.1017/jns.2016.41.
Pandey KC, De S, Mishra PK. Role of proteases in chronic obstructive pulmonary disease. Front Pharmacol. 2017;8:512. https://doi.org/10.3389/fphar.2017.00512.
Patel SS, Savjani JK. Systematic review of plant steroids as potential antiinflammatory agents: current status and future perspectives. J Phytopharmacol. 2015;4(2):121–5.
PBRN A. Pharmacotherapy: a pathophysiologic approach. 2011.
PraticÒ D, Basili S, Vieri M, Cordova C, Violi F, Fitzgerald GA. Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2 α-III, an index of oxidant stress. Am J Respir Crit Care Med. 1998;158(6):1709–14.
Qureshi H, Sharafkhaneh A, Hanania NA. Chronic obstructive pulmonary disease exacerbations: latest evidence and clinical implications. Ther Adv Chronic Dis. 2014;5(5):212–27. https://doi.org/10.1177/2040622314532862.
Rahman I. Antioxidant therapies in COPD. Int J Chron Obstruct Pulmon Dis. 2006;1(1):15–29.
Rahman I, van Schadewijk AA, Crowther AJ, Hiemstra PS, Stolk J, MacNee W, De Boer WI. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;166(4):490–5.
Renzella J, Townsend N, Jewell J, Breda J, Roberts N, Rayner M, Wickramasinghe K. What national and subnational interventions and policies based on Mediterranean and Nordic diets are recommended or implemented in the WHO European Region, and is there evidence of effectiveness in reducing noncommunicable diseases? 2018.
Reynolds HY. Lung inflammation: normal host defense or a complication of some diseases? Annu Rev Med. 1987;38:295–323. https://doi.org/10.1146/annurev.me.38.020187.001455.
Rho HS, Ghimeray AK, Yoo DS, Ahn SM, Kwon SS, Lee KH, Cho DH, Cho JY. Kaempferol and kaempferol rhamnosides with depigmenting and anti-inflammatory properties. Molecules (Basel, Switzerland). 2011;16(4):3338–44. https://doi.org/10.3390/molecules16043338.
Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med. 1992;326(5):298–304. https://doi.org/10.1056/nejm199201303260504.
Santana FPR, Pinheiro NM, Mernak MIB, Righetti RF, Martins MA, Lago JHG, Lopes FDTQDS, Tibério IFLC, Prado CM. Evidences of herbal medicine-derived natural products effects in inflammatory lung diseases. Mediat Inflamm. 2016;2016:2348968. https://doi.org/10.1155/2016/2348968.
Senguttuvan J, Paulsamy S, Karthika K. Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. for in vitro antioxidant activities. Asian Pac J Trop Biomed. 2014;4(Suppl 1):S359–67. https://doi.org/10.12980/APJTB.4.2014C1030.
Sessler CN. Theophylline toxicity: clinical features of 116 consecutive cases. Am J Med. 1990;88(6):567–76.
Simpson JL, Scott R, Boyle MJ, Gibson PG. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology (Carlton, Vic). 2006;11(1):54–61. https://doi.org/10.1111/j.1440-1843.2006.00784.x.
Suissa S, Dell’Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax. 2012;67(11):957–63. https://doi.org/10.1136/thoraxjnl-2011-201518.
Suzuki Y, Wakahara K, Nishio T, Ito S, Hasegawa Y. Airway basophils are increased and activated in eosinophilic asthma. Allergy. 2017;72(10):1532–9. https://doi.org/10.1111/all.13197.
Toledo AC, Sakoda CPP, Perini A, Pinheiro NM, Magalhães RM, Grecco S, Tibério IFLC, Câmara NO, Martins MA, Lago JHG, Prado CM. Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model. Br J Pharmacol. 2013;168(7):1736–49. https://doi.org/10.1111/bph.12062.
U.S. Food and Drug Administration. FDA Drug Safety Communication: drug labels now contain updated recommendations on the appropriate use of long-acting inhaled asthma medications called Long-Acting Beta-Agonists (LABAs). 2010. Retrieved from URL.
Ukena D, Fishman L, Niebling W-B. Bronchial asthma: diagnosis and long-term treatment in adults. Deutsches Arzteblatt Int. 2008;105(21):385–94. https://doi.org/10.3238/arztebl.2008.0385.
van Eeden SF, Sin DD. Chronic obstructive pulmonary disease: a chronic systemic inflammatory disease. Respir Int Rev Thorac Dis. 2008;75(2):224–38. https://doi.org/10.1159/000111820.
Wang J, Fang X, Ge L, Cao F, Zhao L, Wang Z, Xiao W. Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol. PLoS One. 2018;13(5):–e0197563. https://doi.org/10.1371/journal.pone.0197563.
Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, Chu HW. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med. 1999;160(3):1001–8. https://doi.org/10.1164/ajrccm.160.3.9812110.
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Wadhwa, R. et al. (2019). Phytotherapy in Inflammatory Lung Diseases: An Emerging Therapeutic Interventional Approach. In: Kumar, S., Egbuna, C. (eds) Phytochemistry: An in-silico and in-vitro Update. Springer, Singapore. https://doi.org/10.1007/978-981-13-6920-9_18
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