Helical Assemblies

  • Natalya Kurochkina


Repeating structural motifs in proteins exist in many forms as groups of amino acids, secondary structure elements, domains or molecules. Protein assemblies of ankyrins, ARM/HEAT, tetratricopeptide and other repeats contain a repeating unit for which major part represents a pair of antiparallel alpha-helices. These repeating units are packed parallel to each other in a super-helix shaped as solenoid or barrels and rings. Ankyrin repeats form a left-handed spiral whereas ARM and HEAT repeats assemble into a right-handed spiral. Ankyrin repeats contain 24 whereas tetratricopeptide 8 repeats per turn. Repeats such as leucine-rich repeats and TIM-barrel contain one external row of alpha-helices and one internal row of beta-strands. Most of the repeats function as modules for binding other proteins. Amino acid sequence, specific interactions, and distribution on the surface of the secondary structure elements of amino acids determine structure of the assembly.


Helix Assembly Helix interface Chirality Enantioselectivity 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Natalya Kurochkina
    • 1
  1. 1.Department of BiophysicsSchool of Theoretical ModelingWashington, DCUSA

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