• Natalya Kurochkina


Recent advancements in structure elucidation of channels answer many important questions regarding ligand induced conformational transitions which accompany activation and desensitization, allosteric regulation by ions, involvement of regulatory proteins in their function, and many other. Membrane and intracellular proteins such as ion channels, amino acid and lipid transporters and enzymes carry out important metabolic and signaling cellular functions. Structural flexibility, fluctuations and dynamics of channels are important for ligand recognition and function regulation. Selectivity of channels is determined by interactions of the groups in protein interior.


Ion channel Transporter Current Potential Permeability Pore Cellular signal transduction Diffusion 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Natalya Kurochkina
    • 1
  1. 1.Department of BiophysicsSchool of Theoretical ModelingWashington, DCUSA

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