Pesticide Residues in the Soil Cause Cross-Resistance Among Soil Bacteria

  • Rangasamy Kirubakaran
  • Athiappan Murugan
  • Nowsheen Shameem
  • Javid A. Parray
Part of the Microorganisms for Sustainability book series (MICRO, volume 12)


Multi-drug resistance among bacterial pathogens remains a serious problem worldwide. There is no clear and complete understanding about the multi-drug resistance mechanism even though the field is attaining continuous growth. Indiscriminate use of pesticides enabling the bacterial population to acquire multidrug resistance has been revived in this paper. Pesticide residues impose a bacterial system adopted for the stress due to the presence of xenobiotics. The natural evolutionary mutation mechanisms occurring randomly in the core gene sequences responsible for catabolizing complex substrates are the major reasons behind microbial resistance. Mutated gene products produced pose lesser substrate specificity than a wild enzyme. Organophosphorus hydrolase (OPH) or formaldehyde dehydrogenase and laccase are the few enzymes able to degrade many other similar xenobiotics. It has been extrapolated that degradation of many antibiotics by organophosphorus hydrolase is a kind of nonspecific degradation. Organisms growing in metal-polluted sites produce enzymes with different metal ions in their binding sites differing in specificity and conferring cross-resistance to antibiotics.


Pesticide degradation Cross-resistance Soil bacteria pMK-07 (plasmid_Murugan_Kirubakaran) 



All authors acknowledge the Periyar University, Salem, Tamil Nadu, India, for a University Research Fellowship (ref. no PU/A&A-3/URF/2015) and DST-FIST (grant no. SR/FST/LSI-640/2015(c)).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Rangasamy Kirubakaran
    • 1
  • Athiappan Murugan
    • 1
  • Nowsheen Shameem
    • 2
  • Javid A. Parray
    • 3
  1. 1.Department of MicrobiologyPeriyar UniversitySalemIndia
  2. 2.Department of Environmental ScienceCluster University SrinagarJammu and KashmirIndia
  3. 3.Department of Environmental ScienceGovernment SAM Degree College BudgamJammu and KashmirIndia

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