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Microbial Fraction Library: A Screening Source for Drug Discovery

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Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

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Abstract

Natural products are an important source for drug screening because of their diverse chemical properties and biological activities. However, there are several drawbacks in this field such as the duplicate isolation of previously reported metabolites and the inherent difficulty of obtaining a pure compound with significant bioactivity, which requires considerable amount of work, time, and resources. Researchers are continuously devising ways to efficiently discover and isolate novel compounds by developing new screening and sample preparation methods. In this chapter, the current situation of microbial product research is described by introducing screening and sample preparation methods with focus on fraction libraries including our own strategy and discoveries.

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Acknowledgment

We acknowledge Dr. Y. Futamura, Ms. A. Okano, and all the members of our laboratory for their assistance during the work described here. This work was supported in part by JSPS KAKENHI Grant Numbers JP17H06412, JP18H03945, and JP17K07784, AMED under Grant Number JP18cm0106112 (Project for Cancer Research and Therapeutic Evolution/P-CREATE), and the Project of the NARO Bio-oriented Technology Research Advancement Institution (Research program on development of innovative technology).

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  1. RIKEN Center for Sustainable Resource Science, Chemical Biology Research Group, Wako, Saitama, Japan

    Toshihiko Nogawa, Julius Adam V. Lopez & Hiroyuki Osada

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  1. Toshihiko Nogawa
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  2. Julius Adam V. Lopez
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  3. Hiroyuki Osada
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Correspondence to Hiroyuki Osada .

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  1. Department of Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

    Yuichi Kobayashi

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Nogawa, T., Lopez, J.A.V., Osada, H. (2019). Microbial Fraction Library: A Screening Source for Drug Discovery. In: Kobayashi, Y. (eds) Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules. Springer, Singapore. https://doi.org/10.1007/978-981-13-6244-6_1

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