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Spiral Inertial Microfluidics for Cell Separation and Biomedical Applications

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Applications of Microfluidic Systems in Biology and Medicine

Part of the book series: Bioanalysis ((BIOANALYSIS,volume 7))

Abstract

The emergence of omics studies and single cell analysis in biomedicine has advocated a critical need to develop novel cell sorting technologies to process complex and heterogenous biological samples prior analysis. Spiral inertial microfluidics is an enabling membrane-free cell separation technique developed almost a decade ago for high throughput biophysical cell separation, and has since been widely exploited for different biomedical applications. In this chapter, we will provide a comprehensive review on spiral inertial microfluidics including (1) conventional and microfluidic cell sorting techniques, (2) introduction to inertial microfluidics and Dean-coupled inertial focusing, (3) classification of major spiral devices, (4) summary of different biomedical applications, (5) recent advances in next generation spiral cell sorters, and (6) highlight key challenges for future research. With increasing advancement in microfabrication and computational simulation, we envision that spiral inertial microfluidics will play a leading role in driving research and commercialization in clinical diagnostics, as well as other research areas in chemistry and material sciences.

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Authors and Affiliations

  1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

    Ning Liu, Hui Min Tay & Han Wei Hou

  2. School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore

    Chayakorn Petchakup, King Ho Holden Li & Han Wei Hou

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  1. Ning Liu
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  2. Chayakorn Petchakup
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  3. Hui Min Tay
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  4. King Ho Holden Li
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  5. Han Wei Hou
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Correspondence to Han Wei Hou .

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  1. Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Sapporo, Japan

    Manabu Tokeshi

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Liu, N., Petchakup, C., Tay, H.M., Li, K.H.H., Hou, H.W. (2019). Spiral Inertial Microfluidics for Cell Separation and Biomedical Applications. In: Tokeshi, M. (eds) Applications of Microfluidic Systems in Biology and Medicine . Bioanalysis, vol 7. Springer, Singapore. https://doi.org/10.1007/978-981-13-6229-3_5

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