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Paper-Based Microfluidics for Point-of-Care Medical Diagnostics

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Applications of Microfluidic Systems in Biology and Medicine

Part of the book series: Bioanalysis ((BIOANALYSIS,volume 7))

Abstract

In the last decade, the chemistry research community has witnessed an explosive growth of microfluidic devices made of paper (paper-based microfluidics). Use of paper as a substrate material brings several attractive features including extremely low cost and auxiliary pump-free liquid transportation, among others, and application of paper-based microfluidics to on-site medical diagnosis has been actively pursued. To meet the demand for medical diagnostic devices operable by end-users without expert knowledge in resource-limited settings, recent studies on paper-based microfluidics pay particular attention to simplification of user operations prior to an assay (e.g. achieving multistep enzymatic assays by single pipetting) and resulting signal readout (e.g. achieving naked eye-based analog thermometer-style result interpretation). One of the objectives of this chapter is to overview state-of-the-art research progresses in simplification of user operational procedures and development of equipment-free signal readout approaches. In addition, the basics of paper-based microfluidics including a short history of paper-based microfluidics, a comparison of paper-based and conventional plastic- or glass-based microfluidic devices and general requirements for ideal point-of-care testing devices are described. The authors believe this chapter helps researchers new to the field and researchers with different background to learn about analytical applications exclusively achieved by paper-based microfluidics and future challenges in developing “truly” practical medical diagnostic devices.

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Authors and Affiliations

  1. Department of Applied Chemistry, Keio University, Yokohama, Japan

    Kentaro Yamada & Daniel Citterio

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  1. Kentaro Yamada
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  2. Daniel Citterio
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Correspondence to Daniel Citterio .

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  1. Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Sapporo, Japan

    Manabu Tokeshi

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Yamada, K., Citterio, D. (2019). Paper-Based Microfluidics for Point-of-Care Medical Diagnostics. In: Tokeshi, M. (eds) Applications of Microfluidic Systems in Biology and Medicine . Bioanalysis, vol 7. Springer, Singapore. https://doi.org/10.1007/978-981-13-6229-3_13

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