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Overview of Virus Infection and Tumorigenesis

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Abstract

In order to keep metabolic homeostasis and normal physiological environments, cells must maintain metabolic balance. Cancer is a disease, in which metabolic disturbance is one of the most obvious signatures leading to the survival and growth of cancer cells. On the aspect of virus infection to hosts, the metabolic machinery of living cells is manipulated by viruses for completing their life cycles including fulfilling their replication and overcoming the host defense mechanisms. These alterations associated with virus infection can change normal metabolism or/and reconstruct metabolic homeostasis of host cells. In terms of metabolic disorder, there exists a relationship between virus infection and tumorigenesis. In essential, antiviral molecules can maintain metabolic homeostasis of cells. Therefore antiviral molecules may possess antitumor capacity. Antiviral molecules produced during marine hosts’ stress responses to virus infection may be important resources for screening antitumor drugs.

Keywords

Marine organism Stress response Metabolic homeostasis Virus infection Tumorigenesis 

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Institute of BioengineeringZhejiang Academy of Medical SciencesHangzhouChina
  2. 2.College of Life SciencesZhejiang UniversityHangzhouChina

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