Abstract
In this study, we used functional near-infrared spectroscopy to measure the brain hemodynamic responses during a verbal fluency task in both healthy controls (HC) and mild cognitive impairment patients (MCI). We found a greater amplitude of oxy-hemoglobin and deoxy-hemoglobin changes, and a significantly higher value of maximum slope calculated from oxy-hemoglobin change in MCI compared to HC during the task. Our experimental results suggest the potential of using the cerebral hemodynamic responses, especially the maximum slope of oxy-hemoglobin change, as a biomarker for MCI.
Minhee Kim and Thien Nguyen—These authors contributed equally to this work.
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Kim, M. et al. (2020). Investigation of Cerebral Hemodynamic Changes in Mild Cognitive Impairment Due to Alzheimer’s Disease During a Verbal Fluency Task. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore. https://doi.org/10.1007/978-981-13-5859-3_67
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DOI: https://doi.org/10.1007/978-981-13-5859-3_67
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