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Fabrication of N,O Carboxymethyl Chitosan (NOCC)—Aldehyde Hyaluronic Acid (AHA)—Biphasic Calcium Phosphate (BCP)—Poly (Vinyl Phosphonic Acid) (PVPA) Hydrogel for Bone Regeneration

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7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7) (BME 2018)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 69))


N,O carboxymethyl chitosan—aldehyde hyaluronic acid (NOCC-AHA) hydrogel has been proved for successfully cutaneous wound healing due to its porosity, water uptake and biocompatibility. Modification of poly (vinyl phosphonic acid) (PVPA) and biphasis calcium phosphate (BCP) nanoparticles into NOCC-AHA matrix is expected to fabricate a hydrogel for bone regeneration. BCP is main factor of osteogenesis, which shows excellent osteoconductivity, osteoinductivity, biodegradability. Besides, PVPA containing P-C groups in structure support bonding between bone and hydrogel matrix, and increase of bone formation by eliminating osteoclast apoptosis. This research investigates an optimal NOCC: AHA ratio loaded PVPA and BCP in order to optimize the formulation of injectable bone hydrogel. The optimal NOCC-AHA-PVPA-BCP was biocompatible, and showed the porosity, pore size were favorable for bone regeneration, which was confirmed through scanning electron microscope. However, degradation rate of this hydrogel needs improving in further research.

Le Nguyen My An, Nguyen Thanh Truc, Vo Ngoc My Tuyen—contributed equally.

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This research is funded by International University—VNUHCM under grant number T2017-03-BME.

Conflict of Interest The authors declare that they have no conflict of interest.

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Correspondence to Le Nguyen My An .

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An, L.N.M., Truc, N.T., Tuyen, V.N.M., Van Toi, V., Nguyen, TH. (2020). Fabrication of N,O Carboxymethyl Chitosan (NOCC)—Aldehyde Hyaluronic Acid (AHA)—Biphasic Calcium Phosphate (BCP)—Poly (Vinyl Phosphonic Acid) (PVPA) Hydrogel for Bone Regeneration. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore.

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  • Print ISBN: 978-981-13-5858-6

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