Skip to main content

Fabrication of Curcumin/Silver Nanoparticles Loaded Gelatin Scaffold

  • Conference paper
  • First Online:
7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7) (BME 2018)


In this study, a scaffold comprising of curcumin (Cur) and silver nanoparticles (AgNPs) with gelatin (Gel) as carrier matrix was fabricated to develop a novel system potential of antibacterial, anti-inflammatory, and antioxidant properties to aid in wound healing process. UV irradiation was employed in the synthesis of GelAg matrix, followed by the utilization of sonoprecipitation method to encapsulate Cur into GelAg matrix. Since Gel is a polyelectrolyte which possesses different charge when varying pH of solution, the interaction of Gel and AgNPs strongly affects to characteristics of fabricated scaffold. This study aims to investigate the effect of this interaction on morphology of GelAgCur scaffold by varying the amount of AgNPs. The results suggested that at AgNPs equaled to 75 ppm, the system obtained the most potential topography with highly porous structure and even distribution of pores and interconnected pores.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others


  1. Olczyk, P., Mencner, Ł., ukasz, Komosinska-Vassev, K.: The role of the extracellular matrix components in cutaneous wound healing. BioMed Res. Int. 2014, 8 (2014).

  2. Mohanty, C., Sahoo, S.K.: Curcumin and its topical formulations for wound healing applications. Drug Discov. Today 22(10), 1582–1592 (2017).

    Article  Google Scholar 

  3. Mohanty, C., Das, M., Sahoo, S.K.: Emerging role of nanocarriers to increase the solubility and bioavailability of curcumin. Expert Opin. Drug Deliv. 9(11), 1347–1364 (2012).

    Article  Google Scholar 

  4. Kramer, A., Maassen, A.: Wound dressings from a hygienic point of view using the example of sorbion sachet S. GMS Krankenhhyg Interdiszip 4(2), Doc11 (2009).

  5. Nguyen, T.H., Kim, Y.H., Song, H.Y., Lee, B.T.: Nano Ag loaded PVA nano-fibrous mats for skin applications. J. Biomed. Mater. Res. B, Appl. Biomater. 96(2), 225–233 (2011).

  6. Hiep, N.T., Khon, H.C., Niem, V.V.T., Toi, V.V., Ngoc Quyen, T., Hai, N.D., Ngoc Tuan Anh, M.: Microwave-assisted synthesis of chitosan/polyvinyl alcohol silver nanoparticles gel for wound dressing applications. Int. J. Polym. Sci. 2016, 11 (2016).

  7. Nhi, T.T., Khon, H.C., Hoai, N.T.T., Bao, B.C., Quyen, T.N., Van Toi, V., Hiep, N.T.: Fabrication of electrospun polycaprolactone coated withchitosan-silver nanoparticles membranes for wound dressing applications. J. Mater. Sci. Mater. Med. 27(10), 156 (2016).

  8. Nguyen, T.-H., Lee, B.-T.: Fabrication and characterization of cross-linked gelatin electro-spun nano-fibers. J. Biomed. Sci Eng. 03(12), 8 (2010).

  9. Gopinath, D., Ahmed, M.R., Gomathi, K., Chitra, K., Sehgal, P.K., Jayakumar, R.: Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 25(10), 1911–1917 (2004)

    Article  Google Scholar 

  10. Basnet, P., Skalko-Basnet, N.: Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules (Basel, Switzerland) 16(6), 4567–4598 (2011).

    Article  Google Scholar 

  11. Yang, M., Wu, Y., Li, J., Zhou, H., Wang, X.: Binding of curcumin with bovine serum albumin in the presence of iota-carrageenan and implications on the stability and antioxidant activity of curcumin. J. Agric. Food Chem. 61(29), 7150–7155 (2013).

    Article  Google Scholar 

  12. Kumar, A., Dogra, S., Prakash, A.: Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats. Behav. Brain Res. 205(2), 384–390 (2009).

    Article  Google Scholar 

  13. Darroudi, M., Ahmad, M.B., Zak, A.K., Zamiri, R., Hakimi, M.: Fabrication and Characterization of Gelatin Stabilized Silver Nanoparticles under UV-Light. Int. J. Mol. Sci. 12(9), 6346–6356 (2011).

    Article  Google Scholar 

  14. Nguyen, T.-H., Lee, K.-H., Lee, B.-T.: Fabrication of Ag nanoparticles dispersed in PVA nanowire mats by microwave irradiation and electro-spinning. Mater. Sci. Eng. C 30(7), 944–950 (2010).

    Article  Google Scholar 

  15. Marignier, J.L., Belloni, J., Delcourt, M.O., Chevalier, J.P.: Microaggregates of non-noble metals and bimetallic alloys prepared by radiation-induced reduction. Nature 317, 344 (1985).

    Article  Google Scholar 

Download references


This research is funded by Vietnam National University HoChiMinh City (VNU-HCM) under grant number C2018-28-02.

Conflict of Interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Thi-Hiep Nguyen .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Ly, K.L., Van Toi, V., Nguyen, TH. (2020). Fabrication of Curcumin/Silver Nanoparticles Loaded Gelatin Scaffold. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore.

Download citation

  • DOI:

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-5858-6

  • Online ISBN: 978-981-13-5859-3

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics