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Fabrication of Curcumin/Silver Nanoparticles Loaded Gelatin Scaffold

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7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7) (BME 2018)

Abstract

In this study, a scaffold comprising of curcumin (Cur) and silver nanoparticles (AgNPs) with gelatin (Gel) as carrier matrix was fabricated to develop a novel system potential of antibacterial, anti-inflammatory, and antioxidant properties to aid in wound healing process. UV irradiation was employed in the synthesis of GelAg matrix, followed by the utilization of sonoprecipitation method to encapsulate Cur into GelAg matrix. Since Gel is a polyelectrolyte which possesses different charge when varying pH of solution, the interaction of Gel and AgNPs strongly affects to characteristics of fabricated scaffold. This study aims to investigate the effect of this interaction on morphology of GelAgCur scaffold by varying the amount of AgNPs. The results suggested that at AgNPs equaled to 75 ppm, the system obtained the most potential topography with highly porous structure and even distribution of pores and interconnected pores.

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Acknowledgements

This research is funded by Vietnam National University HoChiMinh City (VNU-HCM) under grant number C2018-28-02.

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The authors declare that they have no conflict of interest.

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Correspondence to Thi-Hiep Nguyen .

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Ly, K.L., Van Toi, V., Nguyen, TH. (2020). Fabrication of Curcumin/Silver Nanoparticles Loaded Gelatin Scaffold. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore. https://doi.org/10.1007/978-981-13-5859-3_35

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  • DOI: https://doi.org/10.1007/978-981-13-5859-3_35

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  • Print ISBN: 978-981-13-5858-6

  • Online ISBN: 978-981-13-5859-3

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