Abstract
The enormous potential of a hydrogel from Aldehyde Hyaluronic Acid (AHA)—a modification of Hyaluronan, and N,O-Carboxymethyl Chitosan (NOCC)—a polymer derived from Chitosan, has been discussed in our previous study. This research presents two approaches to combine silver nanoparticles (AgNPs) with the hydrogel in order to yield a bioglue with higher antimicrobial property. The first one utilized the reaction between reactive aldehyde groups in D-glucuronic acid units of the AHA molecular chain and Tollens’ reagent, which is known as silver mirror reaction, while the latter attempted to synthesize NOCC–AHA hydrogel loading AgNPs through thermal decomposition of silver nitrate (AgNO3) with NOCC and AHA respectively. From primary results, heating a mixture of AgNO3–NOCC appeared to attain the best hydrogel in terms of gelation time and elasticity, broadening the application of the hydrogels in the medical field.
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References
Zheng, K., et al.: Antimicrobial silver nanomaterials. Coord. Chem. Rev. 357, 1–17 (2018)
Nhi, T.T., et al.: Fabrication of electrospun polycaprolactone coated withchitosan-silver nanoparticles membranes for wound dressing applications. J. Mater. Sci. Mater. Med. 27(10), 156 (2016)
Nguyen, T.-H., Lee, K.-H., Lee, B.-T.: Fabrication of Ag nanoparticles dispersed in PVA nanowire mats by microwave irradiation and electro-spinning. Mater. Sci. Eng. C 30(7), 944–950 (2010)
Nguyen, T.H., et al.: Nano Ag loaded PVA nano-fibrous mats for skin applications. J. Biomed. Mater. Res. B Appl. Biomater. 96(2), 225–233 (2011)
Shah, J.N., Shah, A.P., Shah, H.J., Vijaykumar B. Sutariya.: Biointeractions of Nanomaterials, p. 73 (2014)
Wei, L., et al.: Silver nanoparticles: synthesis, properties, and therapeutic applications. Drug Discovery Today 20(5), 595–601 (2015)
Caruso, G., Merlo, L., Caffo, M.: Nanoparticles potential: types, mechanisms of action, actual in vitro and animal studies, recent patents. pp. 53–150 (2014)
Naidu Krishna, S., Govender, P., Adam, J.K.: Nano silver particles in biomedical and clinical applications. (2015)
Naahidi, S., et al.: Biocompatibility of hydrogel-based scaffolds for tissue engineering applications. Biotechnol. Adv. 35(5), 530–544 (2017)
Nguyen, N.T.-P., et al.: Synthesis of Cross-Linking Chitosan-Hyaluronic Acid Based Hydrogels for Tissue Engineering Applications. 63,.671-675 (2018)
Ferguson, E.L., et al.: Evaluation of the physical and biological properties of hyaluronan and hyaluronan fragments. Int. J. Pharm. 420(1), 84–92 (2011)
Mohandas, A., et al.: Chitosan-hyaluronic acid/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds. Colloids Surf. B Biointerfaces 127, 105–113 (2015)
Khachatryan, G., et al.: Formation and properties of hyaluronan/nano Ag and hyaluronan-lecithin/nano Ag films. Carbohydr. Polym. 151, 452–457 (2016)
Kemp, M.M., et al.: Hyaluronan- and heparin-reduced silver nanoparticles with antimicrobial properties. Nanomedicine (Lond) 4(4), 421–429 (2009)
Abdel-Mohsen, A.M., et al.: A novel in situ silver/hyaluronan bio-nanocomposite fabrics for wound and chronic ulcer dressing: in vitro and in vivo evaluations. Int. J. Pharm. 520(1–2), 241–253 (2017)
Abdel-Mohsen, A.M., et al.: Green synthesis of hyaluronan fibers with silver nanoparticles. Carbohydr. Polym. 89(2), 411–422 (2012)
Xia, N., et al.: Green synthesis of silver nanoparticles by chemical reduction with hyaluronan. Carbohyd. Polym. 86(2), 956–961 (2011)
Khalil, A.M., et al.: Synthesis, Characterization, and Evaluation of Antimicrobial Activities of Chitosan and Carboxymethyl Chitosan Schiff-Base/Silver Nanoparticles. J Chem. 2017, 1–11 (2017)
Modrzejewska, Z., Zarzycki, R., Sielski, J.: Synthesis of silver nanoparticles in a chitosan solution. Prog. Chem. Appl.chitin 15, 63–72 (2010)
Abdelgawad, A.M., Hudson, S.M., Rojas, O.J.: Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems. Carbohydr. Polym. 100, 166–178 (2014)
Lu, B., et al.: In situ reduction of silver nanoparticles by chitosan-l-glutamic acid/hyaluronic acid: Enhancing antimicrobial and wound-healing activity. Carbohydr. Polym. 173, 556–565 (2017)
Iravani, S., et al.: Synthesis of silver nanoparticles: chemical, physical and biological methods. Res. Pharm. Sci. 9(6), 385 (2014)
Kienskaya, K.I., et al.: Synthesis of silver metal nanodispersions using tollens reagent. Colloid J. 73(2), 294–295 (2011)
Li, X., et al.: Facile synthesis of silver nanoparticles with high concentration via a CTAB-induced silver mirror reaction. Colloids Surf. A 400, 73–79 (2012)
Al-Muhanna, M.K.A., et al.: Preparation of stable sols of silver nanoparticles in aqueous pectin solutions and properties of the sols. Colloid J. 77(6), 677–684 (2015)
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This research is funded by Vietnam National University HoChiMinh City (VNU-HCM) under grant number C2018-28-02.
Conflict of Interest The authors declare that they have no conflict of interest.
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Nguyen, T.NT., Nguyen, D.T., Van Toi, V., Nguyen, TH. (2020). Synthesis of N,O-Carboxymethyl Chitosan-Aldehyde Hyaluronic Acid Hydrogel Loading Silver Nanoparticles. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore. https://doi.org/10.1007/978-981-13-5859-3_30
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