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Investigation of Biphasic Calcium Phosphate on Dentin Occlusion for Dentin Hypersensitivity Treatment

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7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7) (BME 2018)


Dentin hypersensitivity, a common and painful dental condition, can be treated by the promotion of dentin tubule occlusion. The objective of this study is to evaluate tubule occlusion capacity of Biphasic calcium phosphate (BCP) with the available hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) content ratios comprising of 80/20, 40/60 and 20/80. The experimental BCP samples were daily brushed on the demineralized bovine dentin for 7 days. Then, the dentin surface was observed by SEM. These results show that a decrease in the number of exposed dentin tubules varied ac-cording to different HA/β-TCP ratios in BCP powders.

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  1. Goldberg, M., et al.: Dentin: Structure, Composition and Mineralization: The role of dentin ECM in dentin formation and mineralization. Front. Biosci. E3, 711 (2011)

    Article  Google Scholar 

  2. Davari, A., Ataei, E., Assarzadeh, H.: Dentin hypersensitivity: etiology, diagnosis and treatment; a literature review. J. Dent. (Shiraz, Iran) 14(3), 136–45 (2013)

    Google Scholar 

  3. West, N.X., Lussi, A., Seong, J., Hellwig, E.: Dentin hypersensitivity: pain mechanisms and aetiology of exposed cervical dentin. Clin. Oral Investig. 17(1), 9–19 (2013)

    Google Scholar 

  4. Dentin, I.: A new method of treatment for dentin hypersensitivity precipitation of calcium phosphate in situ by Yohji IMAI and Takahiro AKIMOTO Institute for Medical and Dental Engineering. Tokyo Medical and Dental University, 2-3-10 Kanda- Received on July 26, 19, 9(2), 167–172 (1990)

    Google Scholar 

  5. Hiep, N.T., Khon, H.C., Hai, N.D., Taek, L.: Fabrication of PCL/PLGA-BCP porous scaffold for bone tissue engineering applications. J. Biomater. Sci. Polym. Ed. Taylor & Francis engineering applications, 5063(March), 0–1 (2017)

    Google Scholar 

  6. Jang, D.W., Nguyen, T.H., Sarkar, S. K., Lee, B.T.: Microwave sintering and in vitro study of defect-free stable porous multilayered HAp–ZrO2 artificial bone scaffold. Sci. Technol. Adv. Mater. 13(3) (2012)

    Google Scholar 

  7. Palmer, L.C., et al.: Biomimetic systems for hydroxyapatite mineralization inspired by bone and enamel. Chem. Rev. 108(11), 4754–4783 (2008)

    Google Scholar 

  8. Kim, H., Camata, R.P., Vohra, Y.K., Lacefield, W.R.: Control of phase composition in hydroxyapatite/tetracalcium phosphate biphasic thin coatings for biomedical applications. J. Mater. Sci. Mater. Med. 16(10), 961–966 (2005)

    Article  Google Scholar 

  9. Amera, A., et al.: Synthesis and characterization of porous biphasic calcium phosphate scaffold from different porogens for possible bone tissue engineering applications. 43, 183–192 (2011)

    Google Scholar 

  10. Manjubala, I., Sivakumar, M.: In-situ synthesis of biphasic calcium phosphate ceramics using microwave irradiation. Mater. Chem. Phys. 71(3), 272–278 (2001)

    Google Scholar 

  11. Rameshbabu, N., Rao, K.P.: Microwave synthesis, characterization and in-vitro evaluation of nanostructured biphasic calcium phosphates. Curr. Appl. Phys. 9(1), S29–S31 (2009)

    Article  Google Scholar 

  12. Wagner, D.E., Jones, A.D., Zhou, H., Bhaduri, S.B.: Cytocompatibility evaluation of microwave sintered biphasic calcium phosphate scaffolds synthesized using pH control. Mater. Sci. Eng. C 33(3), 1710–1719 (2013)

    Article  Google Scholar 

  13. Gopinath, N.M., et al.: Evaluation of dentifrice containing nano-hydroxyapatite for dentinal hypersensitivity: a randomized controlled trial. J Int Oral Health: JIOH 7(8), 118 (2015)

    Google Scholar 

  14. Naoum, S.J., et al.: Enhancing fluoride mediated dentine sensitivity relief through functionalised tricalcium phosphate activity. Int. Scholarly Res. Not. (2015)

    Google Scholar 

  15. Ngoc, T.N.D., et al.: Preparation and characterization of nano-sized biphasic calcium phosphate (BCP) for demineralized dentin infiltration in hypersensitivity treatment. In: International Conference on the Development of Biomedical Engineering in Vietnam. Springer, Singapore (2017)

    Google Scholar 

  16. Menezes, A.C.S.C.D., Zanet, C.G., Valera, M.C.: Smear layer removal capacity of disinfectant solutions used with and without EDTA for the irrigation of canals: a SEM study. Pesquisa Odontológica Brasileira 17(4), 349–355 (2003)

    Google Scholar 

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This research is funded by International University—VNUHCM under grant number T2017-03-BME.

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Correspondence to Nhi-Thao Ngoc Dang .

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Dang, NT.N., Le, HP., Van Toi, V., Nguyen, TH. (2020). Investigation of Biphasic Calcium Phosphate on Dentin Occlusion for Dentin Hypersensitivity Treatment. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore.

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  • Print ISBN: 978-981-13-5858-6

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