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Plant Based “Green Chemistry 2.0” pp 197–235Cite as

Polyphenols as Natural Antioxidants: Sources, Extraction and Applications in Food, Cosmetics and Drugs

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Part of the book series: Green Chemistry and Sustainable Technology ((GCST))

Abstract

Antioxidants are able to scavenge free radicals that cause degradation of food, pharmaceutical and cosmetic products during processing and storage. Natural ingredients in food products are everywhere continually gaining popularity, and the use of plant extracts in cosmetic formulations are on the rise. Additionally, chemists, pharmacists and nutritionists are focusing on the development of new nutritional applications that target not only to disease prevention but also in improving skin health, appearance of the food product and overcoming any off flavors. This approach is the beginning of the new era where the products intended to promote well-being and health will be available to meet the consumers’ demands. Polyphenols are the most abundant natural antioxidants in nature commonly found in both edible and non-edible parts of plants, and they have been reported to have multiple biological effects, including antioxidant, antimicrobial, anti-viral, anti-inflammatory, analgesic and antipyretic activities. The extraction of polyphenols from plant sources has drawn increasing attention as a low-value source of antioxidants. Although the development in analytical techniques has played a significant role in the detection of a wide range of polyphenols, success still depends on the method of extraction. In literature, several combinations of solvent, temperature, extraction time and agitation speed have been presented in order to achieve maximum phenolic yields, but these conventional proposals are considered as burden on the environment due to the use of high temperatures for long periods of time and secondly due to the effect on the heat-sensitive components of polyphenols. Alternatively, the application of novel techniques such as ultrasound, pulsed electrical field, high-pressure CO2 and others is more welcoming due to their reduced usage of organic solvents, low operational temperatures, short processing times and better quality and yields with high selectivity toward targeted compounds. The extracts rich in phenolic compounds are attractive ingredients for food, cosmetics and pharmaceutical products due to their beneficial biological properties importantly their antioxidant potential. This chapter is aimed at discussing the extraction of polyphenols using environment-friendly techniques and to use these polyphenol-rich extracts in various food, cosmetic and pharmaceutical products.

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References

  1. Adebooye OC, Alashi AM, Aluko RE (2018) A brief review on emerging trends in global polyphenol research. J Food Biochem, e12519

    Google Scholar 

  2. Ajila C, Brar S, Verma M et al (2011) Extraction and analysis of polyphenols: recent trends. Crit Rev Biotechnol 31:227–249

    Article  CAS  PubMed  Google Scholar 

  3. Akbarirad H, Ardabili AG, Kazemeini S et al (2016) An overview on some of important sources of natural antioxidants. Int Food Res J 23

    Google Scholar 

  4. Akram A, Younis A, Akhtar G et al (2017) Comparative efficacy of various essential oil extraction techniques on oil yield and quality of Jasminum sambac L. Sci Int 5:84–95

    Article  CAS  Google Scholar 

  5. Akyol H, Riciputi Y, Capanoglu E et al (2016) Phenolic compounds in the potato and its byproducts: an overview. Int J Mol Sci 17:835

    Article  PubMed Central  CAS  Google Scholar 

  6. Ali IBEH, Bahri R, Chaouachi M et al (2014) Phenolic content, antioxidant and allelopathic activities of various extracts of Thymus numidicus Poir. organs. Ind Crops Prod 62:188–195

    Article  CAS  Google Scholar 

  7. Alok S, Jain SK, Verma A et al (2014) Herbal antioxidant in clinical practice: a review. Asian Pac J Trop Biomed 4:78–84

    Article  PubMed  PubMed Central  Google Scholar 

  8. Alonso C, Martí M, Martínez V et al (2013) Antioxidant cosmeto-textiles: skin assessment. Eur J Pharm Biopharm 84:192–199

    Article  CAS  PubMed  Google Scholar 

  9. Ameer K, Shahbaz HM, Kwon JH (2017) Green extraction methods for polyphenols from plant matrices and their byproducts: a review. Compr Rev Food Sci Food Saf 16:295–315

    Article  PubMed  Google Scholar 

  10. Amid A, Salim R, Adenan M (2010) The factors affecting the extraction condition for neuroprotective activity of Centella asiatica evaluated by metal chelating activity assay. J Appl Sci 10:837–842

    Article  CAS  Google Scholar 

  11. Anbudhasan P, Surendraraj A, Karkuzhali S et al (2014) Natural antioxidants and its benefits. Int J Food Nutr Sci 3:225–232

    Google Scholar 

  12. Andevari GT, Rezaei M (2011) Effect of gelatin coating incorporated with cinnamon oil on the quality of fresh rainbow trout in cold storage. Int J Food Sci Technol 46:2305–2311

    Article  CAS  Google Scholar 

  13. André C, Castanheira I, Cruz J et al (2010) Analytical strategies to evaluate antioxidants in food: a review. Trends Food Sci Technol 21:229–246

    Article  CAS  Google Scholar 

  14. Anunciato TP, da Rocha Filho PA (2012) Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals. J Cosmet Dermatol 11:51–54

    Article  PubMed  Google Scholar 

  15. Anuradha M, Pragyandip P, Richa K et al (2010) Evaluation of neuropharmacological effects of ethanolic extract of Clitorea ternatea flowers. Pharmacologyonline 1:285–292

    Google Scholar 

  16. Apak R, Özyürek M, Güçlü K et al (2016) Antioxidant activity/capacity measurement. 1. Classification, physicochemical principles, mechanisms, and electron transfer (ET)-based assays. J Agric Food Chem 64:997–1027

    Article  CAS  PubMed  Google Scholar 

  17. Arshiya S (2013) The antioxidant effect of certain fruits: a review. J Pharm Sci Res 5:265–268

    Google Scholar 

  18. Asofiei I, Calinescu I, Trifan A et al (2016) Microwave-assisted batch extraction of polyphenols from sea buckthorn leaves. Chem Eng Commun 203:1547–1553

    Article  CAS  Google Scholar 

  19. Atarés L, Marshall LJ, Akhtar M et al (2012) Structure and oxidative stability of oil in water emulsions as affected by rutin and homogenization procedure. Food Chem 134:1418–1424

    Article  PubMed  CAS  Google Scholar 

  20. Awaad AS, Al-Jaber NA (2010) Antioxidant natural plant. RPMP Ethnomed Source Mech 27:1–35

    CAS  Google Scholar 

  21. Azwanida N (2015) A review on the extraction methods use in medicinal plants, principle, strength and limitation. Med Aromat Plants 4(2167–0412):1000196

    Google Scholar 

  22. Babuskin S, Babu PAS, Sasikala M et al (2014) Antimicrobial and antioxidant effects of spice extracts on the shelf life extension of raw chicken meat. Int J Food Microbiol 171:32–40

    Article  PubMed  CAS  Google Scholar 

  23. Baby AR, Haroutiounian-Filho CA, Sarruf FD et al (2009) Influence of urea, isopropanol, and propylene glycol on rutin in vitro release from cosmetic semisolid systems estimated by factorial design. Drug Dev Ind Pharm 35:272–282

    Article  CAS  PubMed  Google Scholar 

  24. Bahadoran Z, Mirmiran P, Azizi F (2013) Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord 12:43

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  25. Bartolomé B, Gómez-Cordovés C (1999) Barley spent grain: release of hydroxycinnamic acids (ferulic and p-coumaric acids) by commercial enzyme preparations. J Sci Food Agric 79:435–439

    Article  Google Scholar 

  26. Bastianetto S, Dumont Y, Duranton A et al (2010) Protective action of resveratrol in human skin: possible involvement of specific receptor binding sites. PLoS ONE 5:e12935

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Blicharski T, Oniszczuk A (2017) Extraction methods for the isolation of isoflavonoids from plant material. Open Chem 15:34–45

    Article  CAS  Google Scholar 

  28. Block G, Patterson B, Subar A (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18:1–29

    Article  CAS  PubMed  Google Scholar 

  29. Borneman Z, Gökmen V, Nijhuis HH (2001) Selective removal of polyphenols and brown colour in apple juices using PES/PVP membranes in a single ultrafiltration process. Sep Purif Technol 22:53–61

    Article  Google Scholar 

  30. Both S, Chemat F, Strube J (2014) Extraction of polyphenols from black tea—Conventional and ultrasound assisted extraction. Ultrason Sonochem 21:1030–1034

    Article  CAS  PubMed  Google Scholar 

  31. Bouayed J, Bohn T (2010) Exogenous antioxidants—double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Medi Cell Longev 3:228–237

    Article  Google Scholar 

  32. Bouwstra JA, Honeywell-Nguyen PL, Gooris GS et al (2003) Structure of the skin barrier and its modulation by vesicular formulations. Prog Lipid Res 42:1–36

    Article  CAS  PubMed  Google Scholar 

  33. Brachet A, Rudaz S, Mateus L et al (2001) Optimisation of accelerated solvent extraction of cocaine and benzoylecgonine from coca leaves. J Sep Sci 24:865–873

    Article  CAS  Google Scholar 

  34. Brewer M (2011) Natural antioxidants: sources, compounds, mechanisms of action, and potential applications. Compr Rev Food Sci Food Saf 10:221–247

    Article  CAS  Google Scholar 

  35. Brglez Mojzer E, Knez Hrnčič M, Škerget M et al (2016) Polyphenols: extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Molecules 21:901

    Article  PubMed Central  CAS  Google Scholar 

  36. Bucić-Kojić A, Planinić M, Tomas S et al (2011) Effect of extraction conditions on the extractability of phenolic compounds from lyophilised fig fruits (Ficus carica L.). Pol J Food Nutr Sci 61:195–199

    Article  Google Scholar 

  37. Butkhup L, Chowtivannakul S, Gaensakoo R et al (2016) Study of the phenolic composition of Shiraz red grape cultivar (Vitis vinifera L.) cultivated in north-eastern Thailand and its antioxidant and antimicrobial activity. S Afr J Enol Vitic 31:89–98

    Google Scholar 

  38. Caleja C, Barros L, Antonio AL et al (2016) Fortification of yogurts with different antioxidant preservatives: a comparative study between natural and synthetic additives. Food Chem 210:262–268

    Article  CAS  PubMed  Google Scholar 

  39. Cassano A, Conidi C, Ruby-Figueroa R et al (2018) Nanofiltration and tight ultrafiltration membranes for the recovery of polyphenols from agro-food by-products. Int J Mol Sci 19:351

    Article  PubMed Central  CAS  Google Scholar 

  40. Charles DJ (2012) Antioxidant properties of spices, herbs and other sources. Springer Science & Business Media

    Google Scholar 

  41. Chen S-K, Hsu C-H, Tsai M-L et al (2013) Inhibition of oxidative stress by low-molecular-weight polysaccharides with various functional groups in skin fibroblasts. Int J Mol Sci 14:19399–19415

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Chupin L, Maunu S, Reynaud S et al (2015) Microwave assisted extraction of maritime pine (Pinus pinaster) bark: impact of particle size and characterization. Ind Crops Prod 65:142–149

    Article  CAS  Google Scholar 

  43. Coïsson J, Travaglia F, Piana G et al (2005) Euterpe oleracea juice as a functional pigment for yogurt. Food Res Int 38:893–897

    Article  CAS  Google Scholar 

  44. Costa P, Gonçalves S, Valentão P et al (2012) Thymus lotocephalus wild plants and in vitro cultures produce different profiles of phenolic compounds with antioxidant activity. Food Chem 135:1253–1260

    Article  CAS  PubMed  Google Scholar 

  45. Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001–1043

    Article  CAS  PubMed  Google Scholar 

  46. Ćujić N, Šavikin K, Janković T et al (2016) Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique. Food Chem 194:135–142

    Article  PubMed  CAS  Google Scholar 

  47. da Silva LMR, de Figueiredo EAT, Ricardo NMPS et al (2014) Quantification of bioactive compounds in pulps and by-products of tropical fruits from Brazil. Food Chem 143:398–404

    Article  CAS  Google Scholar 

  48. Dahmoune F, Nayak B, Moussi K et al (2015) Optimization of microwave-assisted extraction of polyphenols from Myrtus communis L. leaves. Food Chem 166:585–595

    Article  CAS  PubMed  Google Scholar 

  49. Dai J, Mumper RJ (2010) Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15:7313

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Dandena A, Zuka L, Kostova M (2014) Natural antioxidants in black chokeberry marc extracts depending on the extraction method. In: 9th baltic conference on food science and technology “food for consumer well-being”, p 324

    Google Scholar 

  51. De Abreu DP, Losada PP, Maroto J et al (2010) Evaluation of the effectiveness of a new active packaging film containing natural antioxidants (from barley husks) that retard lipid damage in frozen Atlantic salmon (Salmo salar L.). Food Res Int 43:1277–1282

    Article  CAS  Google Scholar 

  52. DeFelice SL (1995) The nutraceutical revolution: its impact on food industry R&D. Trends Food Sci Technol 6:59–61

    Article  CAS  Google Scholar 

  53. Deng G-F, Lin X, Xu X-R et al (2013) Antioxidant capacities and total phenolic contents of 56 vegetables. J Funct Food 5:260–266

    Article  CAS  Google Scholar 

  54. Deng G-F, Shen C, Xu X-R et al (2012) Potential of fruit wastes as natural resources of bioactive compounds. Int J Mol Sci 13:8308–8323

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Deng Y, Zhao Y, Padilla-Zakour O et al (2015) Polyphenols, antioxidant and antimicrobial activities of leaf and bark extracts of Solidago canadensis L. Ind Crops Prod 74:803–809

    Article  CAS  Google Scholar 

  56. Di Mambro VM, Fonseca MJ (2005) Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts. J Pharm Biomed Anal 37:287–295

    Article  PubMed  CAS  Google Scholar 

  57. Di Mattia CD, Sacchetti G, Mastrocola D et al (2010) Surface properties of phenolic compounds and their influence on the dispersion degree and oxidative stability of olive oil O/W emulsions. Food Hydrocoll 24:652–658

    Article  CAS  Google Scholar 

  58. Domínguez-Villegas V, Clares-Naveros B, García-López ML et al (2014) Development and characterization of two nano-structured systems for topical application of flavanones isolated from Eysenhardtia platycarpa. Colloids Surf B Biointerfaces 116:183–192

    Article  PubMed  CAS  Google Scholar 

  59. dos Reis AS, Diedrich C, de Moura C et al (2017) Physico-chemical characteristics of microencapsulated propolis co-product extract and its effect on storage stability of burger meat during storage at −15 ℃. LWT-Food Sci Technol 76:306–313

    Article  CAS  Google Scholar 

  60. Draelos ZD (2010) Nutrition and enhancing youthful-appearing skin. Clin Dermatol 28:400–408

    Article  PubMed  Google Scholar 

  61. Duodu K (2014) Effects of processing on phenolic phytochemicals in cereals and legumes. Cereal Food World 59:64–70

    Article  CAS  Google Scholar 

  62. Echavarria A, Torras C, Pagán J et al (2011) Fruit juice processing and membrane technology application. Food Eng Rev 3:136–158

    Article  CAS  Google Scholar 

  63. Ellong EN, Billard C, Adenet S et al (2015) Polyphenols, carotenoids, vitamin C content in tropical fruits and vegetables and impact of processing methods. Food Nutr Sci 6:299

    CAS  Google Scholar 

  64. Evgeny D, Taisa D (2011) Dissociation energies of O–H bonds of phenols and Hydroperoxides. In: Application of thermodynamics to biological and materials science. IntechOpen

    Google Scholar 

  65. Feetham HJ, Jeong HS, McKesey J et al (2018) Skin care and cosmeceuticals: attitudes and trends among trainees and educators. J Cosmet Dermatol 17:220–226

    Article  PubMed  Google Scholar 

  66. Galvan d’Alessandro L, Kriaa K, Nikov I et al (2012) Ultrasound assisted extraction of polyphenols from black chokeberry. Sep Purif Technol 93:42–47. https://doi.org/10.1016/j.seppur.2012.03.024

    Article  CAS  Google Scholar 

  67. Govindaraj M, Masilamani P, Albert VA et al (2017) Role of antioxidant in seed quality—a review. Agr Rev 38

    Google Scholar 

  68. Guerrero MS, Torres JS, Nuñez MJ (2008) Extraction of polyphenols from white distilled grape pomace: optimization and modelling. Bioresour Technol 99:1311–1318

    Article  CAS  PubMed  Google Scholar 

  69. Guido LF, Moreira MM (2017) Techniques for extraction of Brewer’s spent grain polyphenols: a review. Food Bioprocess Tech 10:1192–1209

    Article  CAS  Google Scholar 

  70. Gupta J, Gupta A, Gupta AK (2017) The flavonoids ameliorates: protective mechanisms in neurodegenerative diseases. Int J Curr Res Chem Pharm Sci 4:1–7

    Article  CAS  Google Scholar 

  71. Habibi S (2014) An upscaled study of a membrane filtration process in presence of biofilms. Doctoral Dissertation, Ecole Centrale Paris

    Google Scholar 

  72. Hamid A, Aiyelaagbe O, Usman L et al (2010) Antioxidants: its medicinal and pharmacological applications. Afri J Pure Appl Chem 4:142–151

    CAS  Google Scholar 

  73. Hasler CM (2002) Functional foods: benefits, concerns and challenges—a position paper from the American Council on Science and Health. J Nutr 132:3772–3781

    Article  CAS  PubMed  Google Scholar 

  74. Heinrich U, Neukam K, Tronnier H et al (2006) Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. J Nutr 136:1565–1569

    Article  CAS  PubMed  Google Scholar 

  75. Horžić D, Jambrak AR, Belščak-Cvitanović A et al (2012) Comparison of conventional and ultrasound assisted extraction techniques of yellow tea and bioactive composition of obtained extracts. Food Bioprocess Tech 5:2858–2870

    Article  Google Scholar 

  76. Hossain M, Barry-Ryan C, Martin-Diana AB et al (2011) Optimisation of accelerated solvent extraction of antioxidant compounds from rosemary (Rosmarinus officinalis L.), marjoram (Origanum majorana L.) and oregano (Origanum vulgare L.) using response surface methodology. Food Chem 126:339–346

    Article  CAS  Google Scholar 

  77. Hossain MA, Al-Toubi WA, Weli AM et al (2013) Identification and characterization of chemical compounds in different crude extracts from leaves of Omani neem. J Taibah Univ Sci 7:181–188

    Article  Google Scholar 

  78. Hu-Zhe Z, Lee H-R, Lee S-H et al (2008) Pectinase assisted extraction of polyphenols from apple pomace. Chinese J Anal Chem 36:306–310

    Google Scholar 

  79. Ibrahim HM, Abou-Arab AA, Salem FMA (2010) Effects on lamb patties quality. J Food Technol 8:134–142

    Article  CAS  Google Scholar 

  80. Ibrahima NA, Zaini MAA (2017) Solvent selection in microwave assisted extraction of castor oil. Chem Eng 56

    Google Scholar 

  81. Jin U-H, Lee J-Y, Kang S-K et al (2005) A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol extract of Euonymus alatus. Life Sci 77:2760–2769

    Article  CAS  PubMed  Google Scholar 

  82. Jovanović A, Petrovic P, Ðordjevic V et al (2017a) Polyphenols extraction from plant sources. Lekovite Sirovine. https://doi.org/10.5937/leksir1737045j

  83. Jovanović AA, Đorđević VB, Zdunić GM et al (2017) Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat-and ultrasound-assisted techniques. Sep Purif Technol 179:369–380

    Article  CAS  Google Scholar 

  84. Junior MRM, Leite AV, Dragano NRV (2010) Supercritical fluid extraction and stabilization of phenolic compounds from natural sources—review (supercritical extraction and stabilization of phenolic compounds). Open Chem Eng J 4

    Google Scholar 

  85. Kapłan M, Najda A (2014) Antioxidant activity of vine fruits depending on their colouring. Chemija 25:51–55

    Google Scholar 

  86. Karaaslan M, Ozden M, Vardin H et al (2011) Phenolic fortification of yogurt using grape and callus extracts. LWT-Food Sci Technol 44:1065–1072

    Article  CAS  Google Scholar 

  87. Karrar EMA (2014) A review on: antioxidant and its impact during the bread making process. Int J Nutr Food Sci 3:592–596

    Article  Google Scholar 

  88. Katiyar SK (2011) Green tea prevents non-melanoma skin cancer by enhancing DNA repair. Arch Biochem Biophys 508:152–158

    Article  CAS  PubMed  Google Scholar 

  89. Katiyar SK, Elmets CA (2001) Green tea polyphenolic antioxidants and skin photoprotection. Int J Oncol 18:1307–1313

    CAS  PubMed  Google Scholar 

  90. Kaufmann B, Christen P (2002) Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction. Phytochem Anal 13:105–113

    Article  CAS  PubMed  Google Scholar 

  91. Keser S, Celik S, Turkoglu S (2013) Total phenolic contents and free-radical scavenging activities of grape (Vitis vinifera L.) and grape products. Int J Food Sci Nutr 64:210–216

    Article  CAS  PubMed  Google Scholar 

  92. Khan BA, Akhtar N, Khan H et al (2013) Development, characterization and antioxidant activity of polysorbate based O/W emulsion containing polyphenols derived from Hippophae rhamnoides and Cassia fistula. Braz J Pharm Sci 49:763–773

    Article  CAS  Google Scholar 

  93. Khan MK, Abert-Vian M, Fabiano-Tixier A-S et al (2010) Ultrasound-assisted extraction of polyphenols (flavanone glycosides) from orange (Citrus sinensis L.) peel. Food Chem 119:851–858

    Article  CAS  Google Scholar 

  94. Khaw K-Y, Parat M-O, Shaw PN et al (2017) Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review. Molecules 22:1186

    Article  PubMed Central  CAS  Google Scholar 

  95. Khoddami A, Wilkes MA, Roberts TH (2013) Techniques for analysis of plant phenolic compounds. Molecules 18:2328–2375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Kitagawa S, Tanaka Y, Tanaka M et al (2009) Enhanced skin delivery of quercetin by microemulsion. J Pharm Pharmacol 61:855–860

    Article  CAS  PubMed  Google Scholar 

  97. Kitagawa S, Yoshii K, S-y Morita et al (2011) Efficient topical delivery of chlorogenic acid by an oil-in-water microemulsion to protect skin against UV-induced damage. Chem Pharm Bull 59:793–796

    Article  CAS  Google Scholar 

  98. Koca I, Tekguler B, Yilmaz VA et al (2018) The use of grape, pomegranate and rosehip seed flours in Turkish noodle (erişte) production. J Food Process Pres 42:e13343

    Article  CAS  Google Scholar 

  99. Kumar GP, Anilakumar K, Naveen S (2015a) Phytochemicals having neuroprotective properties from dietary sources and medicinal herbs. Pharmacogn J 7

    Google Scholar 

  100. Kumar H, Choudhary N, Varsha K et al (2014) Phenolic compounds and their health benefits: a review. J Food Res Technol 2:46–59

    Google Scholar 

  101. Kumar Y, Yadav DN, Ahmad T et al (2015) Recent trends in the use of natural antioxidants for meat and meat products. Compr Rev Food Sci Food Saf 14:796–812

    Article  CAS  Google Scholar 

  102. Le Bourvellec C, Guyot S, Renard C (2009) Interactions between apple (Malus x domestica Borkh.) polyphenols and cell walls modulate the extractability of polysaccharides. Carbohydr Polym 75:251–261

    Article  CAS  Google Scholar 

  103. Le Bourvellec C, Renard C (2012) Interactions between polyphenols and macromolecules: quantification methods and mechanisms. Crit Rev Food Sci Nutr 52:213–248

    Article  PubMed  CAS  Google Scholar 

  104. Lee J, Koo N, Min DB (2004) Reactive oxygen species, aging, and antioxidative nutraceuticals. Compr Rev Food Sci Food Saf 3:21–33

    Article  CAS  PubMed  Google Scholar 

  105. Lee L-S, Lee N, Kim YH et al (2013) Optimization of ultrasonic extraction of phenolic antioxidants from green tea using response surface methodology. Molecules 18:13530–13545

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. Li F, Li S, Li H-B et al (2013) Antiproliferative activity of peels, pulps and seeds of 61 fruits. J Funct Foods 5:1298–1309

    Article  Google Scholar 

  107. Li T, Li J, Hu W et al (2012) Shelf-life extension of crucian carp (Carassius auratus) using natural preservatives during chilled storage. Food Chem 135:140–145

    Article  CAS  Google Scholar 

  108. Li T, Shen P, Liu W et al (2014) Major polyphenolics in pineapple peels and their antioxidant interactions. Int J Food Prop 17:1805–1817

    Article  CAS  Google Scholar 

  109. Lima GPP, Vianello F, Corrêa CR et al (2014) Polyphenols in fruits and vegetables and its effect on human health. Food Nutr Sci 1065–1082

    Article  CAS  Google Scholar 

  110. Löf D, Schillén K, Nilsson L (2011) Flavonoids: precipitation kinetics and interaction with surfactant micelles. J Food Sci 76

    Article  PubMed  CAS  Google Scholar 

  111. Loginov M, Boussetta N, Lebovka N et al (2013) Separation of polyphenols and proteins from flaxseed hull extracts by coagulation and ultrafiltration. J Membrane Sci 442:177–186

    Article  CAS  Google Scholar 

  112. Loprinzi P, Mahoney S (2014) Association between flavonoid-rich fruit and vegetable consumption and total serum bilirubin. Angiology 66(3):286–290. https://doi.org/10.1177/0003319714537111

    Article  CAS  PubMed  Google Scholar 

  113. Loprinzi PD, Mahoney SE (2015) Association between flavonoid-rich fruit and vegetable consumption and total serum bilirubin. Angiology 66:286–290

    Article  PubMed  CAS  Google Scholar 

  114. Łozowicka B, Jankowska M, Rutkowska E et al (2012) Comparison of extraction techniques by matrix solid phase dispersion and liquid-liquid for screening 150 pesticides from soil, and determination by gas chromatography. Pol J Environ Stud 21(4):973–992

    Google Scholar 

  115. Luo Z, Murray BS, Ross A-L et al (2012) Effects of pH on the ability of flavonoids to act as Pickering emulsion stabilizers. Colloids Surf B Biointerfaces 92:84–90

    Article  CAS  PubMed  Google Scholar 

  116. Luo Z, Murray BS, Yusoff A et al (2011) Particle-stabilizing effects of flavonoids at the oil–water interface. J Agric Food Chem 59:2636–2645

    Article  CAS  PubMed  Google Scholar 

  117. Machado BAS, de Abreu Barreto G, Costa AS et al (2015) Determination of parameters for the supercritical extraction of antioxidant compounds from green propolis using carbon dioxide and ethanol as co-solvent. PLoS ONE 10:e0134489

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  118. Maestri D, Nepote V, Lamarque A et al (2006) Natural products as antioxidants. Phytochem Adv Res 37:105–135

    Google Scholar 

  119. Mahoney JR, Graf E (1986) Role of alpha-tocopherol, ascorbic acid, citric acid and EDTA as oxidants in model systems. J Food Sci 51:1293–1296

    Article  CAS  Google Scholar 

  120. Manohar C (2017) Antioxidant and antiproliferative activity of flavonoids from Ontario grown onions by pressurized low polarity water technology. Doctoral Dissertation

    Google Scholar 

  121. Maqsood S, Benjakul S (2010) Comparative studies of four different phenolic compounds on in vitro antioxidative activity and the preventive effect on lipid oxidation of fish oil emulsion and fish mince. Food Chem 119:123–132

    Article  CAS  Google Scholar 

  122. Martorana M, Arcoraci T, Rizza L et al (2013) In vitro antioxidant and in vivo photoprotective effect of pistachio (Pistacia vera L., variety Bronte) seed and skin extracts. Fitoterapia 85:41–48

    Article  CAS  PubMed  Google Scholar 

  123. Materska M, Perucka I (2005) Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L.). J Agric Food Chem 53:1750–1756

    Article  CAS  PubMed  Google Scholar 

  124. Matsui MS, Hsia A, Miller JD et al (2009) Non-sunscreen photoprotection: antioxidants add value to a sunscreen. J Invest Dermatol Symp Proc 1:56–59

    Article  CAS  PubMed  Google Scholar 

  125. Mattiello T, Trifirò E, Jotti GS et al (2009) Effects of pomegranate juice and extract polyphenols on platelet function. J Med Food 12:334–339

    Article  CAS  PubMed  Google Scholar 

  126. Medina-Torres N, Ayora-Talavera T, Espinosa-Andrews H et al (2017) Ultrasound assisted extraction for the recovery of phenolic compounds from vegetable sources. Agron J 7:47

    Article  CAS  Google Scholar 

  127. Medvidović-Kosanović M, Šeruga M, Jakobek L et al (2010) Electrochemical and antioxidant properties of (+)-catechin, quercetin and rutin. Croat Chem Acta 83:197–207

    Google Scholar 

  128. Mennen LI, Walker R, Bennetau-Pelissero C et al (2005) Risks and safety of polyphenol consumption. Am J Clin Nutr 81:326S–329S

    Article  CAS  PubMed  Google Scholar 

  129. Milošević SG, Lepojević ŽD, Zeković ZP et al (2011) Determination of extraction conditions of Ginkgo biloba L. leaves by supercritical CO2 using response surface methodology. Hem Ind 65:147

    Article  CAS  Google Scholar 

  130. Milutinović M, Radovanović N, Ćorović M et al (2015) Optimisation of microwave-assisted extraction parameters for antioxidants from waste Achillea millefolium dust. Ind Crops Prod 77:333–341

    Article  CAS  Google Scholar 

  131. Miron T, Plaza M, Bahrim G et al (2011) Chemical composition of bioactive pressurized extracts of Romanian aromatic plants. J Chromatogr A 1218:4918–4927

    Article  CAS  PubMed  Google Scholar 

  132. Misra K, Dhillon GS, Brar SK et al (2014) Antioxidants. In: Biotransformation of waste biomass into high value biochemicals. Springer, pp 117–138

    Google Scholar 

  133. Mordi R (1993) Mechanism of beta-carotene degradation. Biochem J 292:310

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  134. Morton LW, Caccetta RAA, Puddey IB et al (2000) Chemistry and biological effects of dietary phenolic compounds: relevance to cardiovascular disease. Clin Exp Pharmacol Physiol 27:152–159

    Article  CAS  PubMed  Google Scholar 

  135. Mustafa A, Turner C (2011) Pressurized liquid extraction as a green approach in food and herbal plants extraction: a review. Anal Chim Acta 703:8–18

    Article  CAS  PubMed  Google Scholar 

  136. Nagore D (2018) Development and quality control of natural products, vol 1. Evincepub Publishing

    Google Scholar 

  137. Nahrstedt A, Schmidt M, Jäggi R et al (2007) Willow bark extract: the contribution of polyphenols to the overall effect. Wien Med Wochenschr 157:348–351

    Article  PubMed  Google Scholar 

  138. Naude Y, De Beer W, Jooste S et al (1998) Comparison of supercritical fluid extraction and Soxhlet extraction for the determination of DDT, DDD and DDE in sediment. WATER SA-PRETORIA- 24:205–214

    Google Scholar 

  139. Nawaz H, Shi J, Mittal GS et al (2006) Extraction of polyphenols from grape seeds and concentration by ultrafiltration. Sep Purif Technol 48:176–181. https://doi.org/10.1016/j.seppur.2005.07.006

    Article  CAS  Google Scholar 

  140. Ni Z, Mu Y, Gulati O (2002) Treatment of melasma with Pycnogenol®. Phytother Res 16:567–571

    Article  CAS  PubMed  Google Scholar 

  141. Nikitina V, Kuz’mina LY, Melent’ev A (2007) Antibacterial activity of polyphenolic compounds isolated from plants of Geraniaceae and Rosaceae families. Appl Biochem Micro+ 43:629–634

    Article  CAS  Google Scholar 

  142. O’connell J, Fox P (2001) Significance and applications of phenolic compounds in the production and quality of milk and dairy products: a review. Int Dairy J 11:103–120

    Article  Google Scholar 

  143. Ojagh SM, Rezaei M, Razavi SH et al (2010) Effect of chitosan coatings enriched with cinnamon oil on the quality of refrigerated rainbow trout. Food Chem 120:193–198

    Article  CAS  Google Scholar 

  144. Oksana S, Marian B, Mahendra R et al (2012) Plant phenolic compounds for food, pharmaceutical and cosmetics production. J Med Plants Res 6:2526–2539

    Google Scholar 

  145. Oliveira LL, Carvalho MV, Melo L (2014) Health promoting and sensory properties of phenolic compounds in food. Rev Ceres 61:764–779

    Article  Google Scholar 

  146. Oniszczuk A, Podgórski R (2015) Influence of different extraction methods on the quantification of selected flavonoids and phenolic acids from Tilia cordata inflorescence. Ind Crops Prod 76:509–514

    Article  CAS  Google Scholar 

  147. Osakabe N, Sanbongi C, Yamagishi M et al (1998) Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol. Biosci Biotechnol Biochem 62:1535–1538

    Article  CAS  PubMed  Google Scholar 

  148. Otero-Pareja MJ, Casas L, Fernández-Ponce MT et al (2015) Green extraction of antioxidants from different varieties of red grape pomace. Molecules 20:9686–9702

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  149. Ozcan T, Akpinar-Bayizit A, Yilmaz-Ersan L et al (2014) Phenolics in human health. Int J Chem Eng Appl 5:393

    CAS  Google Scholar 

  150. Pal M, Misra K, Dhillon G et al (2014) Antioxidants. https://doi.org/10.1007/978-1-4614-8005-1_6

    Google Scholar 

  151. Park SY, Chin KB (2010) Evaluation of pre-heating and extraction solvents in antioxidant and antimicrobial activities of garlic, and their application in fresh pork patties. Int J Food Sci Technol 45:365–373

    Article  CAS  Google Scholar 

  152. Pasqualone A, Punzi R, Trani A et al (2017) Enrichment of fresh pasta with antioxidant extracts obtained from artichoke canning by-products by ultrasound-assisted technology and quality characterisation of the end product. Int J Food Sci Technol 52:2078–2087

    Article  CAS  Google Scholar 

  153. Paszkiewicz M, Budzyńska A, Różalska B et al (2012) Immunomodulacyjna rola polifenoli roślinnych The immunomodulatory role of plant polyphenols. Postepy Hig Med Dosw (Online) 66:637–646

    Article  Google Scholar 

  154. Pawlaczyk I, Czerchawski L, Kuliczkowski W et al (2011) Anticoagulant and anti-platelet activity of polyphenolic-polysaccharide preparation isolated from the medicinal plant Erigeron canadensis L. Thromb Res 127:328–340

    Article  CAS  PubMed  Google Scholar 

  155. Pereira D, Pinheiro RS, Heldt LFS et al (2017) Rosemary as natural antioxidant to prevent oxidation in chicken burgers. Food Sci Technol (Campinas)

    Google Scholar 

  156. Pisoschi AM, Pop A, Cimpeanu C et al (2016) Antioxidant capacity determination in plants and plant-derived products: a review. Oxid Med Cell Longev 2016

    Google Scholar 

  157. Prakash D, Sharma G (2014) Phytochemicals of nutraceutical importance. CABI

    Google Scholar 

  158. Prodanov M, Garrido I, Vacas V et al (2008) Ultrafiltration as alternative purification procedure for the characterization of low and high molecular-mass phenolics from almond skins. Anal Chim Acta 609:241–251

    Article  CAS  PubMed  Google Scholar 

  159. Puri M, Sharma D, Barrow CJ (2012) Enzyme-assisted extraction of bioactives from plants. Trends Biotechnol 30:37–44

    Article  CAS  PubMed  Google Scholar 

  160. Rahmalia W, Fabre J-F, Mouloungui Z (2015) Effects of cyclohexane/acetone ratio on bixin extraction yield by accelerated solvent extraction method. Procedia Chem 14:455–464

    Article  CAS  Google Scholar 

  161. Rajbhar K, Dawda H, Mukundan U (2015) Polyphenols: methods of extraction. Sci Revs Chem Commun 5:1–6

    CAS  Google Scholar 

  162. Ranawana V, Raikos V, Campbell F et al (2016) Breads fortified with freeze-dried vegetables: quality and nutritional attributes. Part 1: breads containing oil as an ingredient. Foods 5:19

    Article  PubMed Central  CAS  Google Scholar 

  163. Rather SA, Masoodi F, Akhter R et al (2016) Advances in use of natural antioxidants as food additives for improving the oxidative stability of meat products. Madridge J Food Technol 1:10–17

    Article  Google Scholar 

  164. Ribnicky DM, Roopchand DE, Oren A et al (2014) Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1). Food Chem 142:349–357

    Article  CAS  PubMed  Google Scholar 

  165. Richards MP, Chaiyasit W, McClements DJ et al (2002) Ability of surfactant micelles to alter the partitioning of phenolic antioxidants in oil-in-water emulsions. J Agric Food Chem 50:1254–1259

    Article  CAS  PubMed  Google Scholar 

  166. Rodrigo R, Miranda A, Vergara L (2011) Modulation of endogenous antioxidant system by wine polyphenols in human disease. Clin Chim Acta 412:410–424

    Article  CAS  PubMed  Google Scholar 

  167. Ruela HS, Sabino K, Leal I et al (2013) Hypoglycemic effect of Bumelia sartorum polyphenolic rich extracts. Nat Prod Commun 8:207–210

    CAS  PubMed  Google Scholar 

  168. Rusconi M, Conti A (2010) Theobroma cacao L., the food of the gods: a scientific approach beyond myths and claims. Pharmacol Res 61:5–13

    Article  CAS  PubMed  Google Scholar 

  169. Ruto MC, Ngugi CM, Kareru PG et al (2018) Antioxidant activity and antimicrobial properties of Entada leptostachya and Prosopis juliflora extracts. J Med Plant Econ Devel 2:1–8

    Google Scholar 

  170. Saifuddin N, Saltanat A, Refal H (2014) Enhancing the removal of phenolic compounds from palm oil mill effluent by enzymatic pre-treatment and microwave-assisted extraction. Chem Sci Trans 3:1083–1093

    Google Scholar 

  171. Salina HF, Shima AR, Masniza M et al (2013) Enzyme assisted aqueous extraction and phenolic antioxidants of onion oil. Int J Sci Environ Technol 2:949–955

    Google Scholar 

  172. Saliou C, Rimbach G, Moini H et al (2001) Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B–dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med 30:154–160

    Article  CAS  PubMed  Google Scholar 

  173. Schillaci C, Nepravishta R, Bellomaria A (2014) Antioxidants in food and pharmaceutical research. AJPhSci 1:9–15

    Google Scholar 

  174. Schmidt C, Geweke I, Struck S et al (2018) Blackcurrant pomace from juice processing as partial flour substitute in savoury crackers: dough characteristics and product properties. Int J Food Sci Technol 53:237–245

    Article  CAS  Google Scholar 

  175. Scognamiglio I, De Stefano D, Campani V et al (2013) Nanocarriers for topical administration of resveratrol: a comparative study. Int J Pharm 440:179–187

    Article  CAS  PubMed  Google Scholar 

  176. Selvamuthukumaran M, Shi J (2017) Recent advances in extraction of antioxidants from plant by-products processing industries. Food Qual Saf 1:61–81

    Article  CAS  Google Scholar 

  177. Shahidi F, Janitha P, Wanasundara P (1992) Phenolic antioxidants. Crit Rev Food Sci Nutr 32:67–103

    Article  CAS  PubMed  Google Scholar 

  178. Shamloo M, Babawale EA, Furtado A et al (2017) Effects of genotype and temperature on accumulation of plant secondary metabolites in Canadian and Australian wheat grown under controlled environments. Sci Rep 7:9133

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  179. Shebis Y, Iluz D, Kinel-Tahan Y et al (2013) Natural antioxidants: function and sources. Food Nutr Sci 4:643

    CAS  Google Scholar 

  180. Shori AB, Baba AS (2014) Comparative antioxidant activity, proteolysis and in vitro α-amylase and α-glucosidase inhibition of Allium sativum-yogurts made from cow and camel milk. J Saudi Chem Soc 18:456–463

    Article  CAS  Google Scholar 

  181. Simić VM, Rajković KM, Stojičević SS et al (2016) Optimization of microwave-assisted extraction of total polyphenolic compounds from chokeberries by response surface methodology and artificial neural network. Sep Purif Technol 160:89–97

    Article  CAS  Google Scholar 

  182. Singh R, Kumar R, Venkateshappa R et al (2013) Studies on physicochemical and antioxidant properties of strawberry polyphenol extract-fortified stirred dahi. Int J Dairy Technol 66:103–108

    Article  CAS  Google Scholar 

  183. Spinelli S (2016) Study of microencapsulated bioactive compounds in food products

    Google Scholar 

  184. Stalikas CD (2007) Extraction, separation, and detection methods for phenolic acids and flavonoids. J Sep Sci 30:3268–3295

    Article  CAS  PubMed  Google Scholar 

  185. Sulaiman IAZ (2016) Effect of temperature and sonication on the extraction of gallic acid from Labisia pumila (Kacip Fatimah), vol 11

    Google Scholar 

  186. Tan L, Ji T, Jiang G et al (2014) Simultaneous identification and quantification of five flavonoids in the seeds of Rheum palmatum L. by using accelerated solvent extraction and HPLC–PDA–ESI/MSn. Arab J Chem

    Google Scholar 

  187. Teresa M-M, Magdalena W, Andrzej K (2011) A systematic review of the effect of vitamin C infusion and vitamin E-coated membrane on hemodialysis-induced oxidative stress. In: Hemodialysis-different aspects. InTech

    Google Scholar 

  188. Teruel MR, Garrido MD, Espinosa MC et al (2015) Effect of different format-solvent rosemary extracts (Rosmarinus officinalis) on frozen chicken nuggets quality. Food Chem 172:40–46

    Article  CAS  Google Scholar 

  189. Tomaz I, Maslov L, Stupić D et al (2016) Solid-liquid extraction of phenolics from red grape skins. Acta Chim Slov 63:287–297

    Article  CAS  PubMed  Google Scholar 

  190. Tomović V, Jokanović M, Šojić B et al (2017) Plants as natural antioxidants for meat products. In: IOP conference series: earth and environmental science, vol 1. IOP Publishing, p 012030

    Google Scholar 

  191. Trindade R, Lima A, Andrade-Wartha E et al (2009) Consumer’s evaluation of the effects of gamma irradiation and natural antioxidants on general acceptance of frozen beef burger. Radiat Phys Chem 78:293–300

    Article  CAS  Google Scholar 

  192. Uma D, Ho C, Aida WW (2010) Optimization of extraction parameters of total phenolic compounds from henna (Lawsonia inermis) leaves. Sains Malays 39:119–128

    CAS  Google Scholar 

  193. Vajić U-J, Grujić-Milanović J, Živković J et al (2015) Optimization of extraction of stinging nettle leaf phenolic compounds using response surface methodology. Ind Crops Prod 74:912–917

    Article  CAS  Google Scholar 

  194. Vauzour D, Vafeiadou K, Rodriguez-Mateos A et al (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 3:115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  195. Venkatesh R (2011) Review of the physiological implications of antioxidants in food

    Google Scholar 

  196. Venkatesh R, Sood D (2011) Review of the physiological implications of antioxidants in food. Bachelor of Science Interactive Qualifying Project Worcester Polytechnic Institute, Worcester, Massachusetts, US

    Google Scholar 

  197. Vergara-Salinas JR, Pérez-Jiménez J, Torres JL et al (2012) Effects of temperature and time on polyphenolic content and antioxidant activity in the pressurized hot water extraction of deodorized thyme (Thymus vulgaris). J Agric Food Chem 60:10920–10929

    Article  CAS  PubMed  Google Scholar 

  198. Vetal S, Bodhankar SL, Mohan V et al (2013) Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats. Food Sci Human Wellness 2:59–67

    Article  Google Scholar 

  199. Vidhushi C, Gunasekaran S, Sathiavelu M et al (2016) Importance of waste food products and its antimicrobial activity against food spoilage. Res J Pharm Biol Chem Sci 7:1560–1564

    Google Scholar 

  200. Vladimir-Knežević S, Blažeković B, Štefan MB et al (2012) Plant polyphenols as antioxidants influencing the human health. In: Phytochemicals as nutraceuticals-global approaches to their role in nutrition and health. InTech

    Google Scholar 

  201. Vollmannova A, Margitanova E, Tóth T et al (2013) Cultivar influence on total polyphenol and rutin contents and total antioxidant capacity in buckwheat, Amaranth, and Quinoa Seeds. Czech J Food Sci 31

    Article  Google Scholar 

  202. Wallace TC (2010) Analysis of procyanidins and anthocyanins in food products using chromatographic and spectroscopic techniques. The Ohio State University

    Google Scholar 

  203. Wallace TC, Giusti MM (2008) Determination of color, pigment, and phenolic stability in yogurt systems colored with nonacylated anthocyanins from Berberis boliviana L. as compared to other natural/synthetic colorants. J Food Sci 73

    Article  CAS  PubMed  Google Scholar 

  204. Wang L, Bohn T (2012) Health-promoting food ingredients and functional food processing. In: Nutrition, well-being and health. InTech

    Google Scholar 

  205. Wang L, Weller CL (2006) Recent advances in extraction of nutraceuticals from plants. Trends Food Sci Technol 17:300–312

    Article  CAS  Google Scholar 

  206. Wang S, Melnyk JP, Tsao R et al (2011) How natural dietary antioxidants in fruits, vegetables and legumes promote vascular health. Food Res Int 44:14–22

    Article  CAS  Google Scholar 

  207. Watanabe Y, Nakanishi H, Goto N et al (2010) Antioxidative properties of ascorbic acid and acyl ascorbates in ML/W emulsion. J Am Oil Chem Soc 87:1475–1480

    Article  CAS  Google Scholar 

  208. Williamson G, Day A, Plumb G et al (2000) Human metabolic pathways of dietary flavonoids and cinnamates. Portland Press Limited

    Google Scholar 

  209. Wong Paz JE, Muñiz Márquez DB, Martínez Ávila GCG et al (2015) Ultrasound-assisted extraction of polyphenols from native plants in the Mexican desert. Ultrason Sonochem 22:474–481. https://doi.org/10.1016/j.ultsonch.2014.06.001

    Article  CAS  PubMed  Google Scholar 

  210. Yamakoshi J, Sano A, Tokutake S et al (2004) Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res 18:895–899

    Article  PubMed  Google Scholar 

  211. Yang Z-F, Bai L-P, W-b Huang et al (2014) Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure–activity relationship analysis. Fitoterapia 93:47–53

    Article  CAS  PubMed  Google Scholar 

  212. Yordi EG, Pérez EM, Matos MJ et al (2012) Antioxidant and pro-oxidant effects of polyphenolic compounds and structure-activity relationship evidence. In: Nutrition, well-being and health. InTech

    Google Scholar 

  213. Yoshimura M, Amakura Y, Yoshida T (2011) Polyphenolic compounds in clove and pimento and their antioxidative activities. Biosci Biotechnol Biochem 75:2207–2212

    Article  CAS  PubMed  Google Scholar 

  214. Yu J, Vasanthan T, Temelli F (2001) Analysis of phenolic acids in barley by high-performance liquid chromatography. J Agric Food Chem 49:4352–4358

    Article  CAS  PubMed  Google Scholar 

  215. Yutani R, S-y Morita, Teraoka R et al (2012) Distribution of polyphenols and a surfactant component in skin during aerosol OT microemulsion-enhanced intradermal delivery. Chem Pharm Bull 60:989–994

    Article  CAS  Google Scholar 

  216. Zillich O, Schweiggert-Weisz U, Eisner P et al (2015) Polyphenols as active ingredients for cosmetic products. Int J Cosmetic Sci 37:455–464

    Article  CAS  Google Scholar 

  217. Zillich O, Schweiggert-Weisz U, Hasenkopf K et al (2013) Release and in vitro skin permeation of polyphenols from cosmetic emulsions. Int J Cosmetic Sci 35:491–501

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Home and Food Sciences, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Pakistan

    Muhammad Kamran Khan & Sadia Hassan

  2. School of Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, CV1 5FB, UK

    Larysa Paniwnyk

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  1. Department of Food Science and Engineering, College of Science and Engineering, Jinan University, Guangzhou, Guangdong, China

    Ying Li

  2. INRA, SQPOV, UMR408, Avignon University, Avignon, France

    Farid Chemat

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Khan, M.K., Paniwnyk, L., Hassan, S. (2019). Polyphenols as Natural Antioxidants: Sources, Extraction and Applications in Food, Cosmetics and Drugs. In: Li, Y., Chemat, F. (eds) Plant Based “Green Chemistry 2.0”. Green Chemistry and Sustainable Technology. Springer, Singapore. https://doi.org/10.1007/978-981-13-3810-6_8

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