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Signal Transduction, Ageing and Disease

Part of the Subcellular Biochemistry book series (SCBI,volume 91)

Abstract

Ageing is defined by the loss of functional reserve over time, leading to a decreased tissue homeostasis and increased age-related pathology. The accumulation of damage including DNA damage contributes to driving cell signaling pathways that, in turn, can drive different cell fates, including senescence and apoptosis, as well as mitochondrial dysfunction and inflammation. In addition, the accumulation of cell autonomous damage with time also drives ageing through non-cell autonomous pathways by modulation of signaling pathways. Interestingly, genetic and pharmacologic analysis of factors able to modulate lifespan and healthspan in model organisms and even humans have identified several key signaling pathways including IGF-1, NF-κB, FOXO3, mTOR, Nrf-2 and sirtuins. This review will discuss the roles of several of these key signaling pathways, in particular NF-κB and Nrf2, in modulating ageing and age-related diseases.

Keywords

  • Signaling pathways
  • Age-related disease
  • Senescence
  • Apoptosis
  • Sirtuins
  • Inflammation
  • NF-κB Nrf2

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Acknowledgements

This work was supported by the NIH grants P01-AG043376 (PDR, LJN), U19-AG056278 (PDR, LJN, YS) and the Glenn/AFAR (LJN).

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Correspondence to Paul D. Robbins .

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© 2019 Springer Nature Singapore Pte Ltd.

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Zhang, L., Yousefzadeh, M.J., Suh, Y., Niedernhofer, L.J., Robbins, P.D. (2019). Signal Transduction, Ageing and Disease. In: Harris, J., Korolchuk, V. (eds) Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Subcellular Biochemistry, vol 91. Springer, Singapore. https://doi.org/10.1007/978-981-13-3681-2_9

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