Abstract
Starch from various natural origins and its derivatives are well known to be biodegradable and biocompatible and thus could be promising materials to construct next-generation drug delivery systems (DDSs). With a better understanding of the human physiological basis, advanced stimulus-responsive, target-specific, and transmucosal DDSs has been proven to be effective to deliver therapeutics to various sites in the body to maximize therapeutic potential and minimize side effects. Starch has been modified by various chemical, physical, and/or enzymatic methods to meet the specific requirements of these different DDSs. Yet, so far, starch is not as versatile as synthetic polymers for the development of DDSs, and the field on starch-based DDSs still needs the improvement of the currently developed systems. Future improvements of starch-based DDSs can be achieved on three aspects: (a) to develop modified methods of starch to more greenness, such as physical and enzymatic methods, and genetic engineering technology; (b) to advance starch-based DDSs with new stimulus-responsiveness and high targeting efficiency, such as active targeting delivery; (c) to deepen the research on the plasma hematocompatibility and in vivo distribution patterns of starch-based carriers, and to establish the good in vitro–in vivo correlation of starch-based DDSs for better clinical application. More effort is needed to enlarge the use of starch-based DDSs and its clinical application potential.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Fallingborg J, Christensen LA, Jacobsen BA, Rasmussen SN (1993) Very low intraluminal colonic pH in patients with active ulcerative colitis. Dig Dis Sci 38:1989–1993
Lu Y, Sun W, Gu Z (2014) Stimuli-responsive nanomaterials for therapeutic protein delivery. J Control Release 194:1–19. https://doi.org/10.1016/j.jconrel.2014.08.015
Sasaki Y, Hada R, Nakajima H, Fukuda S, Munakata A (1997) Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: colonic luminal pH in normal subjects and patients with Crohn’s disease. Am J Gastroenterol 92
Zeeman SC, Kossmann J, Smith AM (2010) Starch: its metabolism, evolution, and biotechnological modification in plants. Annu Rev Plant Biol 61:209–234. https://doi.org/10.1146/annurev-arplant-042809-112301
Acknowledgements
This article has been financially supported by the National Key R&D Program of China (no. 2016YFD0400203), the NSFC (31871751), The key project of Guangzhou Science and Technology Program (No.201804020036) and YangFan Innovative and Entrepreneurial Research Team Project (2014YT02S029).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Chen, J., Chen, L., Xie, F., Li, X. (2019). Conclusion and Future Perspectives. In: Drug Delivery Applications of Starch Biopolymer Derivatives. Springer, Singapore. https://doi.org/10.1007/978-981-13-3657-7_7
Download citation
DOI: https://doi.org/10.1007/978-981-13-3657-7_7
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-3656-0
Online ISBN: 978-981-13-3657-7
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)