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Sex Steroids, Cognate Receptors, and Aging

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Models, Molecules and Mechanisms in Biogerontology

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Abstract

Aging signals a gradual deregulation of physiological homeostasis. Steroid hormone actions are an important contributor to this deregulation because of their key involvements in the growth, metabolism, survival, and functional vigor of cells, tissues, and organs. Accumulated evidences show that aging is associated with reduced circulating levels of male and female sex hormones, i.e., androgens and estrogens, respectively, which in turn alter physiological milieu and lead to specific deficits in the organismal vitality. While a number of articles in the literature have provided a generalized description of age-related decline of physiological control mechanisms, in the current chapter, we have focused specifically on the role of sex hormones and sex steroid receptors in age-related bodily dysfunctions. Various segments of our article delved into the current understanding on influences of sex steroids and steroid receptors. Specifically, the roles of androgens, estrogens, and cognate sex steroid receptors in age-accompanied physiological and pathophysiological changes in gene expression and organ functions are discussed. In addition to citing our own studies, information from diverse fields of biology and medicine is taken into consideration in order to present a comprehensive view of sex steroid action with advancing age.

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Acknowledgments

The RKT laboratory has been supported by research grants from the Government of India agencies including UPE-II, UGC (major), CSIR, DST, and ICMR. Central grants from ICMR-CAR, UGC-SAP, and DST-PURSE are also acknowledged. GB was supported by BioCaRE grant from DBT, India. Research in the BC laboratory was supported by Federal grants in the USA (VA-1I01BX000280 and VA-RCS (IK6BX004207); NIH-R01AG-10486; DOD-W81XWH-14-1-0606) and a Foundation grant from Morrison Trust, San Antonio, Texas.

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Authors and Affiliations

  1. Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurgaon, Haryana, India

    Gargi Bagchi

  2. Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India

    Amit K. Dash, Sanjay Kumar & Rakesh K. Tyagi

  3. Central Research Station, Netaji Subhash Chandra Bose Subharti Medical College, Swami Vivekanand Subharti University, Meerut, India

    Sanjay Kumar

  4. Department of Molecular Medicine, School of Medicine, University of Texas Health San Antonio & South Texas Veterans Health Care System, San Antonio, TX, USA

    Shoulei Jiang & Bandana Chatterjee

  5. Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea

    Soon C. Ahn

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  1. Gargi Bagchi
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Correspondence to Bandana Chatterjee or Rakesh K. Tyagi .

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    Pramod C. Rath

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Bagchi, G. et al. (2019). Sex Steroids, Cognate Receptors, and Aging. In: Rath, P. (eds) Models, Molecules and Mechanisms in Biogerontology. Springer, Singapore. https://doi.org/10.1007/978-981-13-3585-3_13

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