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Prevention of Ovarian Cancer

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Preventive Oncology for the Gynecologist

Abstract

Prevention of ovarian cancer is critical in reducing the mortality and morbidity for patients with ovarian cancer. Growing evidence suggests that primary and secondary prevention of ovarian cancer in women with average risk do not confer mortality benefits. Primary surgical prevention through risk-reducing salpingo-oophorectomy is the most effective way of preventing ovarian cancer. This chapter focuses on the assessment of genetic and nongenetic risk factors for ovarian cancer that eventually guide surgical prevention and chemoprophylaxis in women with high-risk disease. It is emphasized that adequate family history and appropriate genetic counseling referral by the physicians is the key to recommend surgical or medical prevention for ovarian cancer. Recent insights into the site of precursor lesion and natural history of the disease have suggested that significant proportion of aggressive ovarian cancer originates as a premalignant lesion in the fallopian tube, making bilateral salpingectomy as a potential preventative option for a group of women requesting short-term ovarian preservation.

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Authors and Affiliations

  1. Department of Gynecology, Indraprastha Apollo Hospital, New Delhi, India

    Sarika Gupta

  2. Department of Gynecologic Oncology, Florida Hospital (AdventHealth) Cancer Institute, Florida State University, Orlando, FL, USA

    Sarfraz Ahmad

  3. Department of Gynecologic Oncology, Colleges of Medicine, University of Central Florida, and Florida State University, Orlando, FL, USA

    Sarfraz Ahmad

  4. Department of Gynecologic Oncology, Orlando Health UF Health Cancer Center, Orlando, FL, USA

    Lorna A. Brudie

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  1. Sarika Gupta
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  2. Sarfraz Ahmad
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  3. Lorna A. Brudie
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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Babu Jagjivan Ram Memorial Hospital, New Delhi, India

    Sumita Mehta

  2. Department of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India

    Anshuja Singla

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Gupta, S., Ahmad, S., Brudie, L.A. (2019). Prevention of Ovarian Cancer. In: Mehta, S., Singla, A. (eds) Preventive Oncology for the Gynecologist. Springer, Singapore. https://doi.org/10.1007/978-981-13-3438-2_20

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