Prevention of Ovarian Cancer

  • Sarika Gupta
  • Sarfraz Ahmad
  • Lorna A. Brudie


Prevention of ovarian cancer is critical in reducing the mortality and morbidity for patients with ovarian cancer. Growing evidence suggests that primary and secondary prevention of ovarian cancer in women with average risk do not confer mortality benefits. Primary surgical prevention through risk-reducing salpingo-oophorectomy is the most effective way of preventing ovarian cancer. This chapter focuses on the assessment of genetic and nongenetic risk factors for ovarian cancer that eventually guide surgical prevention and chemoprophylaxis in women with high-risk disease. It is emphasized that adequate family history and appropriate genetic counseling referral by the physicians is the key to recommend surgical or medical prevention for ovarian cancer. Recent insights into the site of precursor lesion and natural history of the disease have suggested that significant proportion of aggressive ovarian cancer originates as a premalignant lesion in the fallopian tube, making bilateral salpingectomy as a potential preventative option for a group of women requesting short-term ovarian preservation.


Ovarian cancer Prevention of ovarian cancer Screening Risk factors for ovarian cancer Risk assessment models of ovarian cancer Genetic susceptibility to ovarian cancer Risk-reducing salpingo-oophorectomy Surgical prevention/intervention Nonsurgical risk reduction of ovarian cancer Hereditary ovarian cancer BRCA1/BRCA2 testing Peer-reviewed literature summary/update 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Sarika Gupta
    • 1
  • Sarfraz Ahmad
    • 2
    • 3
  • Lorna A. Brudie
    • 4
  1. 1.Department of GynecologyIndraprastha Apollo HospitalNew DelhiIndia
  2. 2.Department of Gynecologic OncologyFlorida Hospital (AdventHealth) Cancer Institute, Florida State UniversityOrlandoUSA
  3. 3.Department of Gynecologic Oncology, Colleges of MedicineUniversity of Central Florida, and Florida State UniversityOrlandoUSA
  4. 4.Department of Gynecologic OncologyOrlando Health UF Health Cancer CenterOrlandoUSA

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