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Pervasive System Biology for Active Compound Valorization in Jatropha

  • Nicolas CarelsEmail author
  • Milena Magalhães
  • Carlyle Ribeiro Lima
  • Bir Bahadur
  • Marcio Argollo de Menezes
Chapter

Abstract

Physic nut (Jatropha curcas L.) is a tree in the family Euphorbiaceae whose members have been known for the production of important natural compounds for therapeutic applications. Physic nut is also one of the few important plant species whose genome has been fully sequenced under high scrutiny, mostly because it is a potential source of oil, which could contribute to alleviate the worldwide energy crisis. However, for being a new crop, J. curcas is not yet domesticated to the point of being industrially productive, and a long way is being undertaken to improve it by selective breeding. During the last decade, the scientific community has performed a huge effort to aggregate knowledge to this plant species. The challenge around J. curcas constitutes a fertile ground to look for natural compounds that may serve as scaffolds for new drug applications. In this chapter, we review the principal conceptual strategies that may be taken to valorize natural compounds in the genus Jatropha.

Keywords

Genome and genetic maps Genome-wide association study Metabolic engineering Pathway modeling Selective breeding 

Notes

Acknowledgment

This contribution was supported by fellowships from the Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças de Populações Negligenciadas (#573642/2008-7) to M.M and C.R.L.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Nicolas Carels
    • 1
    • 2
    Email author
  • Milena Magalhães
    • 1
    • 2
  • Carlyle Ribeiro Lima
    • 1
    • 2
  • Bir Bahadur
    • 3
  • Marcio Argollo de Menezes
    • 4
    • 5
  1. 1.Laboratório de Modelagem de Sistemas Biológicos, Centro de Desenvolvimento Tecnológico em SaúdeFundação Oswaldo CruzRio de JaneiroBrazil
  2. 2.Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças de Populações Negligenciadas, INCT-DPNRio de JaneiroBrazil
  3. 3.Department of BotanyKakatiya UniversityWarangalIndia
  4. 4.Instituto de Física, Universidade Federal FluminenseRio de JaneiroBrazil
  5. 5.Instituto Nacional de Ciência e Tecnologia de Sistemas Complexos, INCT-SCRio de JaneiroBrazil

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