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Germ Cell Tumors and Mixed Germ Cell-Sex Cord-Stromal Tumors of the Ovary

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Gynecologic and Obstetric Pathology, Volume 2

Abstract

Ovarian germ cell tumors (OGCTs) account for approximately 30% of all primary ovarian neoplasia, secondary only to epithelial ovarian tumors. OGCTs occur mostly in younger women and account for approximately 60% of all ovarian tumors in women under 21 years of age. Most OGCTs are pure, and about 10% of OGCTs contain more than one component. For these mixed tumors, the behavior and prognosis are largely determined by the most malignant component; therefore, thorough examination and extensive specimen sampling are critical for identifying and quantifying all components of the tumor. Germ cell tumors generally mimic various stages of normal embryogenesis and have the potential to develop into any normal tissue type; however, the haphazard distributions and composition of various tissue types can be diagnostically challenging. Achieving the correct diagnosis depends on familiarity with this potentially haphazard pattern of various tissue types, correct identification of all tissue components, and recognition of foci of possible malignant transformation. This chapter focuses on the clinicopathologic features of OGCTs and also briefly covers mixed germ cell and sex cord-stromal tumors.

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Authors and Affiliations

  1. Department of Pathology, UTSouthwestern Medical Center, Dallas, TX, USA

    Hao Chen

  2. Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Charles Matthew Quick

  3. Department of Pathology, University of California San Diego, San Diego, CA, USA

    Oluwole Fadare

  4. Departments of Pathology, Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Wenxin Zheng

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  1. Hao Chen
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  2. Charles Matthew Quick
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  4. Wenxin Zheng
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Correspondence to Wenxin Zheng .

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Editors and Affiliations

  1. Department of Pathology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Wenxin Zheng

  2. Department of Pathology, University of California San Diego, San Diego, CA, USA

    Oluwole Fadare

  3. Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Charles Matthew Quick

  4. Department of Pathology, Peking University People’s Hospital, Beijing, China

    Danhua Shen

  5. Department of Obstetrics and Gynecology, Tianjin Gynecologic and Obstetrics Central Hospital, Tianjin, China

    Donghui Guo

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Chen, H., Quick, C.M., Fadare, O., Zheng, W. (2019). Germ Cell Tumors and Mixed Germ Cell-Sex Cord-Stromal Tumors of the Ovary. In: Zheng, W., Fadare, O., Quick, C., Shen, D., Guo, D. (eds) Gynecologic and Obstetric Pathology, Volume 2. Springer, Singapore. https://doi.org/10.1007/978-981-13-3019-3_8

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  • DOI: https://doi.org/10.1007/978-981-13-3019-3_8

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  • Online ISBN: 978-981-13-3019-3

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