Abstract
There are numerous parameters of polymeric biomaterials that can affect the protein adsorption and cell adhesion. The mechanisms responsible for the polymer/protein/cell interactions at the molecular level have not been clearly demonstrated, although many experimental and theoretical efforts have been made to understand these mechanisms. Water interactions have been recognized as fundamental for the protein and cell response to contact with polymers. This chapter focuses on the interfacial water at the polymer/protein/cell interfaces and specific water structure in hydrated biopolymers and bio-inspired water in hydrated synthetic polymers. Additionally, it highlights recent developments in the use of biocompatible polymeric biomaterials for medical devices and provides an overview of the progress made in the design of multifunctional element-block polymers by controlling the bio-inspired water structure through precision polymer synthesis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
a). Hoffman AS (2002) Hydrogels for biomedical applications. Adv Drug Deliv Rev 43:3–13. b). Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (2004) Biomaterials science; an introduction to materials in medicine. Academic, London. c) Special Issue of Prof. T. Tsuruta (2010) J Biomater Sci Polym Ed 21:1827–1970
Tanaka M, Mochizuki A, Ishii N, Motomura T, Hatakeyama T (2002) Study on blood compatibility of poly(2-methoxyethylacrylate). Relationship between water structure and platelet compatibility in poly(2-methoxylethylacrylate-co-2-hydroxyethylmethacrylate). Biomacromolecules 3:36–41
Peppas NA (1987) Hydrogel in medicine and pharmacy, vol 2. CRC Press, Boca Raton
Okano T, Nishiyama S, Shinohara I, Akaike T, Sakurai Y, Kataoka K, Tsuruta T (1981) Effect of hydrophilic and hydrophobic microdomains on mode of interaction between block copolymer and blob platelets. J Biomed Mater Res 15:393–403
Ishihara K, Nomura H, Mihara T, Kurita K, Iwasaki Y, Nakabayashi N (1998) Why do phospholipid polymers reduce protein adsorption? J Biomed Mater Res 39:323–330
Holmlin RE, Chen X, Chapman RG, Takayama S, Whitesides GM (2001) Zwitterionic SAMs that resist nonspecific adsorption of protein from aqueous buffer. Langmuir 17:2841–2850
Kitano H, Tada S, Mori T, Takaha K, Gemmei-Ide M, Tanaka M, Fukuda M, Yokoyama Y (2005) Correlation between the structure of water in the vicinity of carboxybetaine polymers and their blood-compatibility. Langmuir 21:11932–11940
Tanaka M, Motomura T, Kawada M, Anzai T, Kasori Y, Shiroya T, Shimura K, Onishi M, Mochizuki A (2000) Blood compatible aspects of poly(2-methoxyethylacrylate) (PMEA)--relationship between protein adsorption and platelet adhesion on PMEA surface. Biomaterials 21(14):1471–1481
Tanaka M, Motomura T, Ishii N, Shimura K, Onishi M, Mochizuki A, Hatakeyama T (2000) Cold crystallization of water in hydrated poly(2‐methoxyethyl acrylate) (PMEA). Polym Int 49:1709–1713
Tanaka M, Mochizuki A (2004) Effect of water structure on blood compatibility: thermal analysis of water in poly(meth)acrylate. J Biomed Mater Res 68A:684–695
Tanaka M, Mochizuki A, Motomura T, Shimura K, Onishi M, Okahata Y (2001) In situ studies on protein adsorption onto a poly(2-methoxyethyl acrylate) surface by a quartz crystal microbalance. Colloids Surf A Physicochem Eng Asp 193:145–152
Tanaka M, Mochizuki A, Shiroya T, Motomura T, Shimura K, Onishi M, Okahata Y (2002) Study on kinetics of early stage protein adsorption and desorption on poly(2-methoxyethyl acrylate) (PMEA) surface. Colloids Surf A Physicochem Eng Asp 203:195–204
Hayashi T, Tanaka Y, Koide Y, Tanaka M, Hara M (2012) Mechanism underlying bioinertness of self-assembled monolayers of Oligo(ethyleneglycol)-terminated alkanethiols on gold: protein adsorption, platelet adhesion, and surface forces. Phys Chem Chem Phys 14:10194–10206
Sekine T, Tanaka Y, Sato C, Tanaka M, Hayashi T (2015) Evaluation of factors to determine platelet compatibility by using self-assembled monolayers with a chemical gradient. Langmuir 31:7100–7105
Hazlewood CF, Nichols BL, Chamberlain NF (1969) Evidence for the existence of a minimum of two phases of ordered water in skeletal muscle. Nature 222:747
Kuntz ID Jr, Brassfield TS, Law GD, Purcell GV (1969) Hydration of macromolecules. Science 163(3873):1329–1331
Uedaira H (1980) In: Pullman B, Yagi K (eds) Water and metal cations in biological systems. Japan Scientific Societies Press, Tokyo, p 47
Pal SK, Peon J, Zewail AH (2002) Biological water at the protein surface: dynamical solvation probed directly with femtosecond resolution. Proc Natl Acad Sci U S A 99:1763
Morita S, Tanaka M, Ozaki Y (2007) Time-resolved in-situ ATRIR observations of the process of water into a poly(2-methoxyethyl acrylate) (PMEA) film. Langmuir 23:3750–3761
Morita S, Tanaka M (2014) Effect of sodium chloride on hydration structures of PMEA and P(MPC-r-BMA). Langmuir 30:10698–10703
Miwa Y, Ishida H, Saitô H, Tanaka M, Mochizuki A (2009) Network structures and dynamics of dry and swollen poly(acrylate)s. Polymer 50:6091–6099
Hatakayama T, Tanaka M, Hatakayama H (2010) Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC): comparison of the polysaccharides-water systems. Acta Biomater 6:2077–2082
Tanaka M, Hayashi T, Morita S (2013) The roles of water molecules at the biointerface of medical polymers. Polym J 45:701–710
Sato K, Kobayashi S, Kusakari M, Watahiki S, Oikawa M, Hoshiba T, Tanaka M (2015) The relationship between water structure and blood compatibility in poly (2-methoxyethyl Acrylate) (PMEA) analogues. Macromol Biosci 15:1296–1303
Tanaka M, Sato K, Kitakami E, Kobayashi S, Hoshiba T, Fukushima K (2015) Design of biocompatible and biodegradable polymers based on intermediate water concept. Polym J 47:114–121
Hoshiba T, Nemoto E, Sato K, Orui T, Otaki T, Yoshihiro A, Tanaka M (2015) Regulation of the contribution of integrin to cell attachment on poly(2-Methoxyethyl Acrylate) (PMEA) analogous polymers for attachment-based cell enrichment. PLoS One 10:e0136066
Kobayashi S, Fukuda K, Kataoka M, Tanaka M (2016) Regioselective ring-opening metathesis polymerization of 3-substituted cyclooctenes with ether side chains. Macromolecules 49:2493–2501
Osawa K, Kobayashi S, Tanaka M (2016) Synthesis of sequence-specific polymers with amide side chains via regio-/stereoselective ring-opening metathesis polymerization of 3-substitutedcis-cyclooctene. Macromolecules 49:8154–8161
Sato K, Kobayashi S, Sekishita A, Wakui M, Tanaka M (2017) Synthesis and thrombogenicity evaluation evaluation of poly(3-methoxypropionic acid vinyl ester): a candidate for blood compatible polymer. Biomacromolecules 18:1609–1616
Hoshiba T, Nikaido M, Tanaka M (2014) Characterization of the attachment mechanisms of tissue-derived cell lines to blood-compatible polymers. Adv Healthc Mater 3:775–784
Choi H, Tanaka M, Hiragun T, Hide M, Sugimoto K (2014) Non-tumor mast cells cultured in vitro on a honeycomb-like structured film proliferate with multinucleated formation. Nanomedicine 10:313–319
Hirata T, Matsuno H, Kawaguchi D, Hirai T, Yamada N, Tanaka M, Tanaka K (2015) Effect of local chain dynamics on a bio-inert interface. Langmuir 31:3661–3667
Hoshiba T, Otaki T, Nemoto E, Maruyama H, Tanaka M (2015) Blood com- patible polymer for hepatocyte culture with high hepatocyte-specific functions toward bioartificial liver development. ACS Appl Mater Interfaces 7:18096–18103
Khan F, Tanaka M, Ahmad SR, Mater J (2015) Fabrication of polymeric biomaterials: a strategy for tissue engineering and medical devices. Chem B 3:8224–8249
Sato C, Aoki M, Tanaka M (2016) Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. Colloids Surf B: Biointerfaces 145:586–596
Hoshiba T, Nikaido M, Yagi S, Konno I, Yoshihiro A, Tanaka M, Bioact J (2016) Blood compatible poly(2-methoxyethyl acrylate) (PMEA) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells. Compat Polym 31:361–372
Kono K, Hiruma H, Kobayashi S, Sato Y, Tanaka M, Sawada R, Niimi S (2016) In vitro endothelialization test of biomaterials using immortalized endothelial cells. PLoS One 11:e01582898
Hoshiba T, Orui T, Endo C, Sato K, Yoshihiro A, Minagawa Y, Tanaka M (2016) Adhesion-based simple capture and recovery of circulating tumor cells using a blood-compatible and thermo-responsive polymer-coated substrate. RSC Adv 6:89103–89112
Murakami D, Kobayashi S, Tanaka M (2016) Interfacial structures and fibrinogen adsorption at blood-compatible polymer/water interfaces. ACS Bimater Sci Eng 2(12):2122–2126
Hoshiba T, Nemoto E, Sato K, Maruyama H, Endo C, Tanaka M (2016) Promotion of adipogenesis of 3T3-L1 cells on protein adsorption-suppressing poly(2-methoxyethyl acrylate) analogs. Biomacromolecules 17:3808–3815
Fukushima K, Tsai M, Ota T, Haga Y, Matsuzaki K, Inoue Y, Tanaka M (2015) Evaluation of haemocompatibility of hydrated biodegradable aliphatic carbonyl polymers with a subtle difference in a backbone structure on the basis of intermediate water concept and surface hydration. Polym J 47:469–473
Basterretxea A, Haga Y, Sanchez-Sanchez A, Isik M, Irusta L, Tanaka M, Fukushima K, Sardon H (2016) Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst. Eur Polym J 84:750–758
Acknowledgments
The authors are very grateful to Professor Emeritus Teiji Tsuruta (University of Tokyo) for his valuable advice. The author also would like to thank all members of the Tsuruta Forum for their helpful comments.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Tanaka, M. (2019). Design of Multifunctional Soft Biomaterials: Based on the Intermediate Water Concept. In: Chujo, Y. (eds) New Polymeric Materials Based on Element-Blocks. Springer, Singapore. https://doi.org/10.1007/978-981-13-2889-3_23
Download citation
DOI: https://doi.org/10.1007/978-981-13-2889-3_23
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-2888-6
Online ISBN: 978-981-13-2889-3
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)