Extracellular Matrix and Ageing

Birch, Helen L.

doi:10.1007/978-981-13-2835-0_7

Extracellular Matrix and Ageing

Helen L. Birch⁴

Chapter
First Online: 19 February 2019

3621 Accesses
39 Citations

Part of the Subcellular Biochemistry book series (SCBI,volume 90)

Abstract

The extracellular matrix (ECM) provides the environment for many cells types within the body and, in addition to the well recognised role as a structural support, influences many important cell process within the body. As a result, age-related changes to the proteins of the ECM have far reaching consequences with the potential to disrupt many different aspects of homeostasis and healthy function. The proteins collagen and elastin are the most abundant in the ECM and their ability to function as a structural support and provide mechanical stability results from the formation of supra-molecular structures. Collagen and elastin have a long half-life, as required by their structural role, which leaves them vulnerable to a range of post-translational modifications. In this chapter the role of the ECM is discussed and the component proteins introduced. Major age-related modifications including glycation, carbamylation and fragmentation and the impact these have on ECM function are reviewed.

Keywords

Collagen
Elastin
Ageing
Advanced glycation end-products
Fragmentation

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Fig. 7.3

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Helen L. Birch

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Institute of Molecular Physiology, Johannes Gutenberg University, Mainz, Germany
Prof. Dr. Dr. J. Robin Harris
Newcastle University, Newcastle upon Tyne, UK
Dr. Viktor I. Korolchuk

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Birch, H.L. (2018). Extracellular Matrix and Ageing. In: Harris, J., Korolchuk, V. (eds) Biochemistry and Cell Biology of Ageing: Part I Biomedical Science. Subcellular Biochemistry, vol 90. Springer, Singapore. https://doi.org/10.1007/978-981-13-2835-0_7

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