Creatine, Creatine Kinase, and Aging

  • Nathalie Sumien
  • Ritu A. Shetty
  • Eric B. GonzalesEmail author
Part of the Subcellular Biochemistry book series (SCBI, volume 90)


With an ever aging population, identifying interventions that can alleviate age-related functional declines has become increasingly important. Dietary supplements have taken center stage based on various health claims and have become a multi-million dollar business. One such supplement is creatine, a major contributor to normal cellular physiology. Creatine, an energy source that can be endogenously synthesized or obtained through diet and supplement, is involved primarily in cellular metabolism via ATP replenishment. The goal of this chapter is to summarize how creatine and its associated enzyme, creatine kinase, act under normal physiological conditions, and how altered levels of either may lead to detrimental functional outcomes. Furthermore, we will focus on the effect of aging on the creatine system and how supplementation may affect the aging process and perhaps reverse it.


Creatine Creatine kinase Aging Supplementation Muscle function Motor and cognitive function Anti-aging intervention 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Nathalie Sumien
    • 1
  • Ritu A. Shetty
    • 1
  • Eric B. Gonzales
    • 2
    Email author
  1. 1.Department of Pharmacology and NeuroscienceUniversity of North Texas Health Science CenterFort WorthUSA
  2. 2.Department of Medical EducationTCU and UNTHSC School of MedicineFort WorthUSA

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