Abstract
In the approximately 5–10% of asthma patients whose condition is poorly controlled, asthma is present even if the patient is treated with high-dose inhalational steroids and long-acting beta 2 agonists. We cauterized a bronchus of 3–10 mm inner diameter at 65 °C for patients with such severe asthma. Bronchial thermoplasty, which reduces the quantity of the airway smooth muscle, was introduced as an epoch-making treatment in Japan from 2015. Airway contraction is reduced through the reduction of the quantity of smooth muscle in the airway, and the palliation of symptoms is obtained. The efficacy and safety of bronchial thermoplasty is currently being examined by a multicenter study in Japan.
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References
Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–73.
Danek CJ, Lombard CM, Dungworth DL, et al. Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs. J Appl Physiol (1985). 2004;97(5):1946–53.
Miller JD, Cox G, Vincic L, et al. A prospective feasibility study of bronchial thermoplasty in the human airway. Chest. 2005;127(6):1999–2006.
Cox G, Thomson NC, Rubin AS, AIR Trial Study Group, et al. Asthma control during the year after bronchial thermoplasty. N Engl J Med. 2007;356(13):1327–37.
Pavord ID, Cox G, Thomson NC, RISA Trial Study Group, et al. Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med. 2007;176(12):1185–91.
Castro M, Rubin AS, Laviolette M, AIR2 Trial Study Group, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010;181(2):116–24.
Iikura M, Hojo M, Nagano N, et al. Bronchial thermoplasty for severe uncontrolled asthma in Japan. Allergol Int. 2018;67(2):273–5.
Ishii Y. Clinical usefulness of bronchial thermoplasty and its real procedure. JJSRE. 2017;39:447–52.
Laxmanan B, Egressy K, Murgu SD, White SR, Hogarth DK. Advances in bronchial thermoplasty. Chest. 2016;150(3):694–704.
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Iwanaga, T., Sano, A., Nishiyama, O., Sano, H., Tohda, Y. (2019). Bronchial Thermoplasty: Japanese Experiences. In: Yokoyama, A. (eds) Advances in Asthma. Respiratory Disease Series: Diagnostic Tools and Disease Managements. Springer, Singapore. https://doi.org/10.1007/978-981-13-2790-2_14
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DOI: https://doi.org/10.1007/978-981-13-2790-2_14
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