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Perinatal Stem Cells pp 83–91Cite as

The Characteristics and Therapeutic Application of Perinatal Mesenchymal Stem Cell-Derived Exosomes

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Abstract

Exosomes are secretory vesicles with diameters range from 40 to 100 nm, which are considered to play an important role in intercellular communication. Exosomes contain proteins, lipids, microRNAs, mRNAs, and other noncoding RNAs. It is demonstrated that exosomes derived from diverse cell types have different therapeutic potentials. Recently, perinatal mesenchymal stem cells (MSCs) have attracted much attention due to their unique characteristics. Therefore, perinatal MSC-derived exosomes may provide novel therapeutic potentials. In this chapter, we will summarize the characteristics of exosomes. Moreover, we will focus on recent reports on perinatal MSC-derived exosomes and consider their therapeutic potentials. Finally, we will introduce some strategies to modify exosome for tracking their fate in vivo and enhancing their therapeutic efficiency.

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Authors and Affiliations

  1. State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Tianjin, China

    Fengxia Ma

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  1. Fengxia Ma
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Editors and Affiliations

  1. Beijing Engineering Laboratory of Perinatal Stem Cells, Jiangxi Engineering Research Center for Stem Cell, Health & Biotech Co., Beijing, China

    Zhong Chao Han

  2. Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

    Tsuneo A. Takahashi

  3. State Key Lab of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China

    Zhibo Han

  4. School of Medicine, Nankai University, Tianjin, China

    Zongjin Li

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Ma, F. (2019). The Characteristics and Therapeutic Application of Perinatal Mesenchymal Stem Cell-Derived Exosomes. In: Han, Z., Takahashi, T., Han, Z., Li, Z. (eds) Perinatal Stem Cells. Springer, Singapore. https://doi.org/10.1007/978-981-13-2703-2_8

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