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Kashin-Beck Disease (KBD)

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Book cover Endemic Disease in China

Part of the book series: Public Health in China ((PUBHECH,volume 2))

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Abstract

An endemic osteochondral disease, Kashin-Beck disease (KBD), is widely found in the diagonal southern-west to northern-east zone in China and North Korea and in the Eastern Siberia of Russia. There is evidence that in China alone 1.3 million individuals have some level symptom of the syndrome, while the amount may even be underestimated. Opposite to the global development of progression of osteoarthritis, the number of people suffering from KBD has notably decreased in China, having the highest prevalence in the late 1950s. Up to 2013, about 640,000 patients are affected by KBD, and 1.16 million are in danger developing the disease in 377 counties of 13 provinces of China. It is likely that the decrease in KBD prevalence is thanks to the preventive measures carried out in China. These include distribution of dietary supplements and clean water to millions of people and even relocation of whole villages. Despite the good achievements in the fight against KBD, the investigators know rather little about the environmental and genetic risk factors related to KBD or the rationale of the preventive actions. Remarkably, new data on the cellular and molecular level events in KBD has begun to accumulate, which hopefully can uncover the fundamental basis of the disease.

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Authors and Affiliations

  1. Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of PR of China, Xi’an Jiaotong University, Xi’an, China

    Xiong Guo

  2. Xi’an Jiaotong University, Xi’an, China

    Feng Zhang, Xi Wang, Cuiyan Wu, Yujie Ning, Fangfang Yu & Mohammad Imran Younus

  3. University of Umeå, Umeå, Sweden

    Mikko Juhani Lammi

  4. Institute of Kashin-Beck Disease, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China

    Jun Yu, Hui Liu & Yanhong Cao

Authors
  1. Xiong Guo
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  2. Feng Zhang
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  3. Xi Wang
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  9. Jun Yu
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Correspondence to Xiong Guo .

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Editors and Affiliations

  1. Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China

    Dianjun Sun

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Guo, X. et al. (2019). Kashin-Beck Disease (KBD). In: Sun, D. (eds) Endemic Disease in China. Public Health in China, vol 2. Springer, Singapore. https://doi.org/10.1007/978-981-13-2529-8_5

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  • DOI: https://doi.org/10.1007/978-981-13-2529-8_5

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2528-1

  • Online ISBN: 978-981-13-2529-8

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