Abstract
Vascular tumors of the retina generally include four distinct lesions: retinal capillary hemangioma, retinal cavernous hemangioma, racemose hemangioma, and vasoproliferative tumor of the retina. A main differentiation point between these entities arises by classifying them as either congenital in origin or acquired during the lifetime. The congenital retinal vascular tumors include the retinal cavernous hemangioma and the racemose hemangioma. From an ultrastructural standpoint, the vasculature components of these tumors maintain the integrity of endothelial tight junctions throughout life. Clinically, this translates into a lack of exudation or leakage irrespective of the depth of the tumor. In turn, the acquired tumors, retinal capillary hemangioma, and vasoproliferative tumor lack tight junctions and commonly present clinically with an exudative component.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Augsburger JJ, Goldberg RE, Shields JA, et al. Changing appearance of retinal arteriovenous malformation. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Albrecht Von Graefes. Arch Klin Exp Ophthalmol. 1980;215:65–70.
Avci R, Yilmaz S, Inan UU, et al. Vitreoretinal surgery for patients with severe exudative and proliferative manifestations of retinal capillary hemangioblastoma because of von hippel-lindau disease. Retina. 2017;37:782–8.
Bakri SJ, Sears JE, Singh AD. Transient closure of a retinal capillary hemangioma with verteporfin photodynamic therapy. Retina. 2005;25:1103–4.
Dobyns WB, Michels VV, Groover RV, et al. Familial cavernous malformations of the central nervous system and retina. Ann Neurol. 1987;21:578–83.
Messmer E, Laqua H, Wessing A, et al. Nine cases of cavernous hemangioma of the retina. Am J Ophthalmol. 1983;95:383–90.
Ponce FA, Han PP, Spetzler RF, et al. Associated arteriovenous malformation of the orbit and brain: a case of Wyburn-Mason syndrome without retinal involvement. Case report. J Neurosurg. 2001;95:346–9.
Pringle E, Chen S, Rubinstein A, et al. Optical coherence tomography in retinal cavernous haemangioma may explain the mechanism of vitreous haemorrhage. Eye (Lond). 2009;23:1242–3.
Qin XJ, Huang C, Lai K. Retinal vein occlusion in retinal racemose hemangioma: a case report and literature review of ocular complications in this rare retinal vascular disorder. BMC Ophthalmol. 2014;14:101. https://doi.org/10.1186/1471-2415-14-101.
Raja D, Benz MS, Murray TG, et al. Salvage external beam radiotherapy of retinal capillary hemangiomas secondary to von Hippel-Lindau disease: visual and anatomic outcomes. Ophthalmology. 2004;111:150–3.
Sachdeva R, Dadgostar H, Kaiser PK, et al. Verteporfin photodynamic therapy of six eyes with retinal capillary haemangioma. Acta Ophthalmol. 2010;88(8):e334–40. https://doi.org/10.1111/j.1755-3768.2010.02008.x.
Schmidt-Erfurth UM, Kusserow C, Barbazetto IA, et al. Benefits and complications of photodynamic therapy of papillary capillary hemangiomas. Ophthalmology. 2002;109:1256–66.
Singh AD, Shields CL, Shields JA, et al. von Hippel-Lindau disease. Surv Ophthalmol. 2001;46:117–42.
Singh AD, Ahmad NN, Shields CL. Solitary retinal capillary hemangioma: lack of genetic evidence for von Hippel-Lindau disease. Ophthalmic Genet. 2002a;23:21–7.
Singh AD, Nouri M, Shields CL, et al. Treatment of retinal capillary hemangioma. Ophthalmology. 2002b;109:1799–806.
Slim E, Antoun J, Kourie HR, et al. Intravitreal bevacizumab for retinal capillary hemangioblastoma: a case series and literature review. Can J Ophthalmol. 2014;49:450–7.
Stolle C, Glenn G, Zbar B, et al. Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene. Hum Mutat. 1998;12:417–23.
Wang W, Chen L. Cavrnous hemangioma of the retina: a comprehensive review of the literature (1934-2015). Retina. 2017;37:611–21.
Webster AR, Maher ER, Moore AT. Clinical characteristics of ocular angiomatosis in von Hippel-Lindau disease and correlation with germline mutation. Arch Ophthalmol. 1999;117:371–8.
Wong WT, Liang KJ, Hammel K, et al. Intravitreal ranibizumab therapy for retinal capillary hemangioblastoma related to von Hippel-Lindau disease. Ophthalmology. 2008;115:1957–64.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Echegaray, J.J., Neto, R.B., Singh, A.D. (2019). Retinal Vascular Tumors. In: Rojanaporn, D. (eds) Ocular Oncology. Retina Atlas. Springer, Singapore. https://doi.org/10.1007/978-981-13-2336-2_6
Download citation
DOI: https://doi.org/10.1007/978-981-13-2336-2_6
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-2335-5
Online ISBN: 978-981-13-2336-2
eBook Packages: MedicineMedicine (R0)