Abstract
A 6-year-old female with a history of spina bifida is admitted for presumed acute pyelonephritis with fevers, vomiting, and abdominal pain. Her urine culture and sensitivity results are pending. She has a past medical history significant for a ventriculoperitoneal (VP) shunt, gastrostomy tube, and neurogenic bladder. She has been admitted several times in the past for pyelonephritis with bacteremia. Her baseline renal function equates to an estimated glomerular filtration rate (eGFR) of approximately 60 mL/min/1.73 m2. You are consulted by the hospitalist to provide input regarding the choice of antibiotic and dosage to be prescribed.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsSuggested Readings
Pierson-Marchandise M, Gras V, Moragny J, Micallef J, Gaboriau L, Picard S, Choukroun G, Masmoudi K, Liabeuf S, French National Network of Pharmacovigilance Centres. The drugs that mostly frequently induce acute kidney injury: a case - noncase study of a pharmacovigilance database. Br J Clin Pharmacol. 2017;83(6):1341–9. https://doi.org/10.1111/bcp.13216.
Aronoff G, Berns J, Brier M, et al. Drug prescribing in renal failure. 4th ed. Philadelphia: American College of Physicians; 1999. p. 1–12.
Abouelkheir M, Alsubaie S. Acute kidney injury induced by concomitant use of vancomycin and piperacillin-tazobactam in pediatrics. Pediatr Int. 2018;60(2):136–41.
Wu H, Huang J. Drug-induced nephrotoxicity: pathogenic mechanisms, biomarkers and prevention strategies. Curr Drug Metab. 2018;19(7):559–67.
Nolin TD, Himmelfarb J. Mechanisms of drug-induced nephrotoxicity. In: Uetrecht J, editor. Adverse drug reactions. Handbook of experimental pharmacology, vol. 196. Berlin: Springer; 2010. p. 111–30.
Schetz M, Dasta J, Goldstein S, Golper T. Drug-induced acute kidney injury. Curr Opin Crit Care. 2005;11(6):555–65.
Pannu N, Nadim MK. An overview of drug-induced acute kidney injury. Crit Care Med. 2008;36(4 Suppl):S216–23. https://doi.org/10.1097/CCM.0b013e318168e375.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Chand, D.H., Patwardhan, M. (2019). Drug-Induced Nephrotoxicity. In: Sethi, S., Raina, R., McCulloch, M., Bunchman, T. (eds) Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook. Springer, Singapore. https://doi.org/10.1007/978-981-13-2276-1_18
Download citation
DOI: https://doi.org/10.1007/978-981-13-2276-1_18
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-2275-4
Online ISBN: 978-981-13-2276-1
eBook Packages: MedicineMedicine (R0)