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Modeling Hereditary Spastic Paraplegias in Fruit Flies: Potential of Its Genetic Paraphernalia

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Insights into Human Neurodegeneration: Lessons Learnt from Drosophila

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Abstract

Hereditary spastic paraplegias (HSPs) are a large group of heterogeneous inherited neurological diseases characterized by spasticity or progressive stiffness in the lower extremities. The genetic basis of HSPs is very diverse, and the number of candidate genes being identified has been increasing due to better diagnostic approaches, including the advance and access of next-generation sequencing. Currently, the number of genomic loci associated with HSPs in humans are more than 80 and the corresponding number of identifiable genes are greater than 70. Drosophila has evolved as a powerful genetic model to explore these disease-causing genes in vivo. A comprehensive review of the previously studied HSP causative genes in flies revealed high similarity and potential of these organisms to provide novel insights into the underlying cellular pathways. We also found high conservation of HSP-related genes in flies with more than 60% of the human genes having corresponding sequences in Drosophila. Therefore, the study of HSP genes in flies can unravel valuable information for designing future therapeutic strategies.

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  1. Department of Biotechnology, University of Kashmir, Srinagar, India

    Sajad Ahmad Bhat

  2. Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, Madhya Pradesh, India

    Sajad Ahmad Bhat & Vimlesh Kumar

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  1. Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Mousumi Mutsuddi

  2. Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Ashim Mukherjee

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Bhat, S.A., Kumar, V. (2019). Modeling Hereditary Spastic Paraplegias in Fruit Flies: Potential of Its Genetic Paraphernalia. In: Mutsuddi, M., Mukherjee, A. (eds) Insights into Human Neurodegeneration: Lessons Learnt from Drosophila. Springer, Singapore. https://doi.org/10.1007/978-981-13-2218-1_14

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