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Harnessing the Combined Power of SAXS and NMR

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1105)

Abstract

Single types of methodologies are no longer sufficient to adequately describe complex biological structures. As a result, integrated approaches that combine complementary data are being developed. This chapter describes the integration of nuclear magnetic resonance and small-angle scattering approaches to characterize solution structures of multi-domain proteins.

Keywords

  • Integrated structural biology
  • Multi-domain proteins
  • NMR
  • SAXS
  • Molecular dynamics simulations

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Acknowledgment

I thank all former and present members of Gronenborn laboratory for their contributions to our studies referenced here and Teresa Brosenitsch for excellent editorial help. This work was supported by a National Institutes of Health Grant RO1GM080642 (A.M.G.).

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Correspondence to A. M. Gronenborn .

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Gronenborn, A.M. (2018). Harnessing the Combined Power of SAXS and NMR. In: Nakamura, H., Kleywegt, G., Burley, S., Markley, J. (eds) Integrative Structural Biology with Hybrid Methods. Advances in Experimental Medicine and Biology, vol 1105. Springer, Singapore. https://doi.org/10.1007/978-981-13-2200-6_11

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