Complete Dielectric Resonator Model of Human Brain from MRI Data: A Journey from Connectome Neural Branching to Single Protein
Using freely available MRI data of structural components mapping of human brain from different universities (primarily Rajat Jain, 25; 38-years-old lady from UK), we have built actual structural database of the human brain components, e.g., neural network connectome data, blood vessel map, ventricles, cavities for cerebral-spinal fluid, hippocampus regions of midbrain, etc. In previous studies, we have argued that every single element in the brain behaves as dielectric resonator. Here, we run rigorous dielectric resonance simulation to verify the hypothesis that the scale-free resonance does exist in the material architecture of the brain. From MRI-derived structures, we simulate the resonance frequencies, distribution of electric, and magnetic field of the brain components in CST and detect the phase response behavior, specially phase transition and symmetry breaking as a function of resonance frequency. We find that electric and magnetic fields distribute inhomogeneously in the dielectric structure, not just in the neural branches but also in the blood vessels and proteins like axon and microtubule bundles. The resonance frequencies show a characteristic topological pattern, specially, every single brain component is splitting electromagnetic field in such a way that at certain frequencies magnetic field dominates and at certain resonance frequency, electric field dominates. This distinct behavior of splitting fields at all spatial and time scale was never reported before. We speculate that there may exist a unified geometric pattern hidden in the vibrational frequencies of the brain components, which hold important information for the brain’s information processing.
KeywordsConnectome Brain Dielectric resonator Neuron Microtubule Axon
We thank UCSD and other unknown universities for making MRI data free and sincerely thank numerous unknown researchers who worked relentlessly to produce structural data used in producing all seven figures in this paper. Authors acknowledge the Asian office of Aerospace R&D (AOARD), a part of United States Air Force (USAF) for the Grant no. FA2386-16-1-0003 (2016–2019) on the electromagnetic resonance based communication and intelligence of biomaterials.
- 2.Hodgkin, A.L., Huxley, A.F., Katz, B.: Measurements of current-voltage relations in the membrane of the giant axon of Loligo. J. Phys. 116, 424–448 (1952)Google Scholar
- 6.McCormick, D.A., Shu, Y., Yu, Y.: Hodgkin and Huxley model—still standing? Nature 445, E1–E2, References on challenging the Hodgkin Huxley Action Potential Initiation in the Hodgkin-Huxley Model, Lucy J. Colwell mail, Michael P. Brenner Published (2009). https://doi.org/10.1371/journal.pcbi.1000265 (2007)MathSciNetCrossRefGoogle Scholar
- 9.Hurdal, M.K., Bowers, P.L., Stephenson, K., Sumners, D.W.L., Rehm, K., Schaper, K., Rottenberg, D.A.: Quasi-conformally flat mapping the human cerebellum. In: Taylor, C., Colchester, A. (eds.) Medical Image Computing and Computer-Assisted Intervention—MICCAI’99. Lecture Notes in Computer Science, pp. 279–286. Springer, Berlin (1999)CrossRefGoogle Scholar
- 10.Van Essen, D.C.: Cause and effect in cortical folding. Nat. Rev. Neurosci. 8, 12 (2007)Google Scholar
- 15.Hoke, M., Lehnertz, K., Pantev, C., Lütkenhöner, B.: Spatiotemporal aspects of synergetic processes in the auditory cortex as revealed by the magnetoencephalogram. In: Basar, E., Bullock, T.H. (eds.) Brain Dynamics, pp. 84–108. Springer-Verlag (1989)Google Scholar
- 20.Stahl, S.M.: Structure and Function of Neurons, 3rd edn. Cambridge University Press. http://assets.cambridge.org/97805218/57024/excerpt/9780521857024_excerpt.pdf
- 23.Hagmann, P.: From diffusion MRI to brain connectomeics. Ph.D. Thesis, Ecole Polytechnique Federale de Lausanne (2005)Google Scholar
- 24.Sporns, O.: The human connectome: a complex network. http://dx.doi.org/10.1016/S0920-9964(12)70100-7
- 29.Waves in blood vessels. http://hplgit.github.io/INF5620/doc/pub/sphinxwave/_main_wave009.html
- 32.Agrawal, L., Sahu, S., Ghosh, S., Shiga, T., Fujita, D., Bandyopadhyay, A.: Inventing atomic resolution scanning dielectric microscopy to see a single protein complex operation live at resonance in a neuron without touching or adulterating the cell. J. Integrat. Neurosci. 15(4), 435–462 (2016)CrossRefGoogle Scholar
- 33.The ventricular system is a set of hollow cavities in the brain filled with cerebro spinal fluid. https://www.boundless.com/physiology/textbooks/boundless-anatomy-and-physiology-textbook/central-nervous-system-12/protection-of-the-brain-116/ventricles-636-9194/