Abstract
Viral infections are likely to act as an inducible trigger of cutaneous adverse drug reactions (cADRs) in an HLA-associated manner. The most likely candidate involved in the development of cADRs is the family Herpesviridae. Although reactivation of herpesviruses observed in cADRs is generally regarded as the result, but not the cause, of general immune dysregulation in cADRs, we also discuss the alternative possibility that the reactivation may be a causal factor in the pathogenesis. If so, the implications could open up new areas for potential therapeutic intervention in cADRs.
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- ADR:
-
Adverse drug reactions
- ART:
-
Antiretroviral therapy
- cADR:
-
Cutaneous adverse drug reactions
- cMOs:
-
Classical monocytes
- CMV:
-
Cytomegalovirus
- DiHS:
-
Drug-induced hypersensitivity syndrome
- DRESS:
-
Drug reaction with eosinophilia and systemic symptoms
- EBV:
-
Epstein-Barr virus
- GVHD:
-
Graft-vs.-host disease
- HHV-6:
-
Human Herpesvirus 6
- HLA:
-
Human leukocyte antigens
- IRIS:
-
Immune reconstitution inflammatory syndrome
- MOs:
-
Monocytes
- PV:
-
Pemphigus vulgaris
- SJS/TEN:
-
Stevens–Johnson syndrome/Toxic epidermal necrolysis
- VZV:
-
Varicella zoster virus
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Shiohara, T., Kano, Y., Mizukawa, Y., Aoyama, Y. (2019). Viral Reactivation in Cutaneous Adverse Drug Reactions. In: Shear, N., Dodiuk-Gad, R. (eds) Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions. Adis, Singapore. https://doi.org/10.1007/978-981-13-1489-6_4
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DOI: https://doi.org/10.1007/978-981-13-1489-6_4
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