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Evaluation of Drug Safety Literature: A Guide for the Practicing Dermatologist

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Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions

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Abstract

A literature search is an integral part of the evaluation of a patient with a suspected adverse drug reaction and can provide information on clinical presentation and diagnosis, time course, dose relationship, reversibility, cross-reactivity, treatment and prognosis, mechanism and pathogenesis, and testing. Using a case example, we will demonstrate the components of a literature search, using a systematic approach to identify relevant information (Aoki et al. 2013). This summary is not meant to be an exhaustive review, but rather provides the practicing dermatologist with the necessary skills to conduct a literature search.

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Abbreviations

ADR:

Adverse drug reactions

AGEP:

Acute generalized exanthematous pustulosis

CARE:

Case report

CBC:

Complete blood count

CCB:

Calcium channel blockers

CRD:

Centre for reviews and dissemination

DARE:

Database of reviews of effects

FAERS:

US FDA Adverse Event Reporting System

FDA:

US Food and Drug Administration

LFTs:

Liver function tests

MeSH:

Medical subject headings

NHSEED:

NHS economic evaluation database

TRIP:

Turning research into practice

VAERS:

US CDC Vaccine Adverse Event Reporting System

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Author information

Authors and Affiliations

  1. Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Sandra R. Knowles & Jackie Campbell

  2. Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada

    Sandra R. Knowles

Authors
  1. Sandra R. Knowles
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  2. Jackie Campbell
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Corresponding author

Correspondence to Sandra R. Knowles .

Editor information

Editors and Affiliations

  1. University of Toronto Medical School, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Neil H. Shear

  2. Department of Dermatology, Emek Medical Center, Afula, Israel

    Roni P. Dodiuk-Gad

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Knowles, S.R., Campbell, J. (2019). Evaluation of Drug Safety Literature: A Guide for the Practicing Dermatologist. In: Shear, N., Dodiuk-Gad, R. (eds) Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions. Adis, Singapore. https://doi.org/10.1007/978-981-13-1489-6_17

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  • DOI: https://doi.org/10.1007/978-981-13-1489-6_17

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  • Publisher Name: Adis, Singapore

  • Print ISBN: 978-981-13-1488-9

  • Online ISBN: 978-981-13-1489-6

  • eBook Packages: MedicineMedicine (R0)

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