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RON Receptor Tyrosine Kinase in Pancreatic Cancer Progression

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Role of Tyrosine Kinases in Gastrointestinal Malignancies

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Abstract

The receptor d’origine nantais (RON) is a tyrosine kinase (TK) receptor, an oncogene expressed on several tissue occupant macrophage populations. Overexpression as well as constitutive actuation of RON receptor TK has been identified in a variety of tumors including pancreatic cancer, leading to tumor progression. RON is among the two individuals that belongs to MET receptor tyrosine kinase family, along with parent receptor MET. In pancreatic cells, RON is an essential K-Ras effector, and its biological response is intervened by authoritative of its ligand, macrophage-stimulating protein/hepatocyte growth factor-like protein. Under physiological conditions, ligand-mediated receptor activation and its stimulation through its receptor-binding sites are the significant reasons for RON activation. Various oncogenic signaling pathways involved in cell growth, migration, apoptosis, and survival were instigated by activated RON. However, in pancreatic cancer, overexpression and mutations, generations of splicing variants, and, seldom amplified gene copy numbers are responsible for RON activation. The pathobiological noteworthiness of RON overexpression in pancreatic cancer presently cannot seem to be fully elucidated. This chapter explains the contemporary state of information about RON biology in relation to pancreatic cancer and also reviews its probable role as a therapeutic target.

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Author information

Authors and Affiliations

  1. P.G. Department of Zoology, Berhampur University, Berhampur, Odisha, India

    Tapan K. Barik & Surya N. Swain

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  1. Tapan K. Barik
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  2. Surya N. Swain
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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

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Barik, T.K., Swain, S.N. (2018). RON Receptor Tyrosine Kinase in Pancreatic Cancer Progression. In: Nagaraju, G. (eds) Role of Tyrosine Kinases in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-13-1486-5_6

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