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Alcoholic/Non-Alcoholic Digestive Diseases pp 65–86Cite as

Diabetes in Liver Disease

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Abstract

A high prevalence of diabetes mellitus has been reported in patients with chronic liver disease (CLD). Increasing evidence suggests that diabetes mellitus and its treatment have a significant impact on the clinical course of CLD. This review summarized the prevalence, diagnosis, and mechanisms of diabetes mellitus in patients with CLD. We also reviewed the clinical impact and therapeutic strategy for diabetes mellitus in patients with CLD. Recent progress using antidiabetic medication in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and hepatocellular carcinoma was also discussed.

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Abbreviations

AMPK:

AMP-activated kinase

CGMS:

continuous glucose monitoring system

CI:

confidence interval

CLD:

chronic liver disease

DPP4:

dipeptidyl peptidase IV

HbA1c:

glycated hemoglobin

HBV:

hepatitis B virus

HCC:

hepatocellular carcinoma

HCV:

hepatitis C virus

HR:

hazard ratio

IGF-1:

insulin-like growth factor-1

IGT:

impaired glucose tolerance

Loxl2:

lysyl oxidase like 2

MAPK:

mitogen-activated protein kinase

NAFLD:

non-alcoholic fatty liver disease

OR:

odds ratio

PNPLA3:

patatin-like phospholipase domain-containing 3

QOL:

quality of life

SGLT2:

sodium glucose cotransporter 2

VLDL:

very-low-density lipoprotein

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Conflict of Interest Statement

All authors disclose no conflicts.

Financial Support

This work was supported by JSPS Grant-in-Aid for Scientific Research (C) JP17K09444.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan

    Takumi Kawaguchi, Dan Nakano & Takuji Torimura

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  1. Takumi Kawaguchi
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  2. Dan Nakano
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  3. Takuji Torimura
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Correspondence to Takumi Kawaguchi .

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Editors and Affiliations

  1. Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan

    Hitoshi Yoshiji

  2. Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan

    Kosuke Kaji

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Kawaguchi, T., Nakano, D., Torimura, T. (2019). Diabetes in Liver Disease. In: Yoshiji, H., Kaji, K. (eds) Alcoholic/Non-Alcoholic Digestive Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-1465-0_7

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  • DOI: https://doi.org/10.1007/978-981-13-1465-0_7

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