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Next Step Lymphatic Filariasis Eradication: Current Status in the Development of a Vaccine Against Lymphatic Filariasis

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Lymphatic Filariasis

Abstract

Lymphatic filariasis (LF) is a mosquito-transmitted neglected tropical parasitic infection that causes most gruesome clinical outcome in the patients resulting in severe physical disability. Mass drug administration (MDA), spearheaded by the World Health Organization (WHO), is one of the most successful elimination strategies for any infection worldwide. India started implementing MDA since 2004 and has successfully reduced the incidence of the infection to a level that can be now easily managed. Few reports of non-compliance to MDA still remain. This has resulted in the presence of residual infections in some areas designated as “hotspots.” Transmission assessment surveys need to identify these “hotspots.” Before the momentum of MDA wanes, it is critically important to capitalize the success gained by MDA by planning toward an eradication strategy for LF in India. Eradication will not be possible with MDA alone. There is a need to develop a more sustainable strategy such as vaccine and vector control along with MDA. This paper reviews the current status of vaccine development against lymphatic filariasis and future prospects.

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Correspondence to Ramaswamy Kalyanasundaram .

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Kalyanasundaram, R. (2018). Next Step Lymphatic Filariasis Eradication: Current Status in the Development of a Vaccine Against Lymphatic Filariasis. In: Tyagi, B. (eds) Lymphatic Filariasis. Springer, Singapore. https://doi.org/10.1007/978-981-13-1391-2_3

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