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Central Circadian Clock Regulates Energy Metabolism

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Neural Regulation of Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1090))

  • The original version of this chapter was revised: the funding information in the acknowledgements section was revised as requested by the authors. The correction to this chapter can be found at https://doi.org/10.1007/978-981-13-1286-1_13

Abstract

Our body not only responds to environmental changes but also anticipates them. The light and dark cycle with the period of about 24 h is a recurring environmental change that determines the diurnal variation in food availability and safety from predators in nature. As a result, the circadian clock is evolved in most animals to align locomotor behaviors and energy metabolism with the light cue. The central circadian clock in mammals is located at the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain. We here review the molecular and anatomic architecture of the central circadian clock in mammals, describe the experimental and observational evidence that suggests a critical role of the central circadian clock in shaping systemic energy metabolism, and discuss the involvement of endocrine factors, neuropeptides, and the autonomic nervous system in the metabolic functions of the central circadian clock.

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Change history

  • 02 July 2019

    The below correction has been carried out in the page 93 of the current version

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Acknowledgments

We apologize to colleagues whose work we failed to include due to an oversight on our part. The authors’ laboratories are supported by the National Institute of Health (ES027544 and CA215591) and American Heart Association (30970064).

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Authors and Affiliations

  1. International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Guolian Ding

  2. Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

    Guolian Ding, Yingyun Gong & Zheng Sun

  3. Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Yingyun Gong

  4. Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA

    Kristin L. Eckel-Mahan

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  1. Guolian Ding
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  4. Zheng Sun
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Correspondence to Kristin L. Eckel-Mahan or Zheng Sun .

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  1. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

    Qi Wu

  2. Department of Anatomy, Histology and Embryology, Health Science Center, Peking University, Beijing, China

    Ruimao Zheng

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Ding, G., Gong, Y., Eckel-Mahan, K.L., Sun, Z. (2018). Central Circadian Clock Regulates Energy Metabolism. In: Wu, Q., Zheng, R. (eds) Neural Regulation of Metabolism. Advances in Experimental Medicine and Biology, vol 1090. Springer, Singapore. https://doi.org/10.1007/978-981-13-1286-1_5

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