Abstract
Undesirable antrhopogenic activities leads to pollution of river waters which is mainly caused by many factors such as every industry including pharmaceutical, agricultural sector and human generated sewage sludge and water, is a matter of great apprehension. Because societal progress together with population progression and environment change, therefore, it could cause a large-scale opposing impacts on the surface quality of water. On the other hand, the medicinal compounds are characteristically prepared in an industry through a series of processes which lead towards the occurrence of varied types of compounds in its effluents, which are produced in dissimilar processes. Moreover, abundant amount of aqua are utilized for cleaning of equipment and rock-solid material cake or taking out of potent chemicals from raw materials. The occurrence of pharmaceutical complexes in potable water chiefly derived from two diverse origins: the manufacturing process of medicinal industries and every day or usual use of pharmaceutical products, which results in their occurrence in metropolitan and rural effluents. Therefore, the effluents produced in various methods during the preparation of drugs and pharmaceuticals products comprise of a different variety of compounds. These compounds in natural environment also cause resistance among sensitive microbes, which may further transfer the resistant genome to sensitive microbes. Additionally, recycling of wastewater after contaminant removal, whether pharmaceutical or other industries, is generally wanted by the manufacturing industry. Keeping in mind the shortage of water reserves, it has become absolutely essential to comprehend and prepare sophisticated procedures for the cure of pharmaceutical effluents as part of crucial water administration system. In this chapter, the several origins of effluents from the drug industry are detected along with the types of contaminants and the best existing methods and technologies to eliminate them from the ecosystem.
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Acharya BK, Mohana S, Madamwar D (2008) Anaerobic treatment of distillery spent wash: a study on up flow anaerobic fixed film bioreactor. Bioresour Technol 99:4621–4626
Agarry SE, Solomon BO (2008) Kinetics of batch microbial degradation of phenols by indigenous Pseudomonas fluorescence. Int J Environ Sci Technol 5:223–232
Akunna JC, Clark M (2000) Performance of a granular-bed anaerobic baffled reactor (GRABBR) treating whisky distillery wastewater. Bioresour Technol 74:257–261
Amin A, Naik ATR, Azhar M, Nayak H (2013) Bioremediation of different waste waters—a review. Cont J Fish Aquat Sci 7:7–17
Asamudo NU, Daba AS, Ezeronye OU (2005) Bioremediation of textile effluent using Phanerochaete chrysosporium. Afr J Biotechnol 4:1548–1553
Ashfaq A, Khatoon A (2014) Evaluating toxicological effects, pollution control and wastewater management in pharmaceutical industry. Int J Curr Res Aca Rev 2:54–65
Awaleh MO, Soubaneh YD (2014) Wastewater treatment in chemical industries: the concept and current technologies. Hydrol Curr Res 5:1–12
Bala JD (2011) Physicochemical assessment and effects of pharmaceutical wastewater in Nigeria. IUP J Environ Sci 5:36–48
Balcioglu IA, Otker M (2004) Pre-treatment of antibiotic formulation wastewater by O3, O3/H2O2, and O3/UV processes. Turkish J Eng Env Sci 28:325–331
Billore SK, Singh N, Ram HK, Sharma JK, Singh VP, Nelson RM, Dass P (2001) Treatment of a molasses based distillery effluent in a constructed wetland in central India. Water Sci Technol 44:441–448
Branyik T, Kuncova G, Paca J (2000) The use of silica gel prepared by sol-gel method and polyurethane foam as microbial carriers in the continuous degradation of phenol. Appl Microbiol Biotechnol 54:168–172
Chang CY, Chang JS, Vigneswaran S, Kandasamy J (2008) Pharmaceutical wastewater treatment by membrane bioreactor process—a case study in southern Taiwan. Desalination 234:393–401
Chelliapan S, Yuzir A, Md Din MF, Sallis PJ (2011) Anaerobic pre-treatment of pharmaceutical wastewater using packed bed reactor. Int J Chem Eng Appl 2:32–37
Chen Y, Cheng JJ, Creamer KS (2008) Inhibition of anaerobic digestion process: a review. Bioresour Technol 99:4044–4064 cpcb.nic.in/openpdffile.php?id=UmVwb3J0RmlsZXMvTmV3SXRlbV8xMTZfR3VpZGVsaW5lc29mIHdhdGVycXVhbGl0eW1vbml0b3JpbmdfMzEuMDcuMDgucGRm
Choudhary S, Parmar N (2013) Hazard assessment of liquid effluent treatment plant in pharmaceutical industry. VSRD J Int Technol Non Technol Res 4(9):209–214
Das MP, Bashwant M, Kumar K, Das J (2012) Control of pharmaceutical effluent parameters through bioremediation. J Chem Pharm Res 4:1061–1065
Deegan AM, Shaik B, Nolan K, Urell K, Oelgemöller M, Tobin J, Morrissey A (2011) Treatment options for wastewater effluents from pharmaceutical companies. Int J Environ Sci Technol 8:649–666
Deepali JN (2012) Study of ground water quality in and around SIDCUL industrial area, Haridwar, Uttarakhand, India. J Appl Technol Environ Sanitation 2:129–134
Dixit D, Parmar N (2013) Treatment of pharmaceutical waste water by electro-coagulation and natural coagulation process: review. VSRD Int J Technol NonTechnol Res 4:79–88
El-Gohary FA, Abou-Elela SI, Aly HI (1995) Evaluation of biological technologies for wastewater treatment in the pharmaceutical industry. Water Sci Technol 32:13–20
Enright AM, McHugh S, Collins G, O’Flaherty V (2005) Low-temperature anaerobic biological treatment of solvent containing pharmaceutical wastewater. Water Res 39:4587–4596
Fang HHP, Chui HK, Li YY (1994) Microbial structure and activity of UASB granules treating different wastewaters. Water Sci Technol 30:87–96
Gadipelly C, Gonzalez AP, Yadav GD, Ortiz I, Ibanez R, Rathod VK, Marathe KV (2014) Pharmaceutical industry wastewater: review of the technologies for water treatment and reuse. Ind Eng Chem Res 53:11571–11592
Garcia A, Rivas HM, Figueroa JL, Monroe AL (1995) Case history: pharmaceutical wastewater treatment plant upgrade, Smith Kline Beecham Pharmaceuticals Company. Desalination 102:255–263
Ghosh M, Verma SC, Mengoni A, Tripathi AK (2004) Enrichment and identification of bacteria capable of reducing chemical oxygen demand of anaerobically treated spent wash. J Appl Microbiol 96:1278–1286
Gome A, Upadhyay K (2013) Biodegradability assessment of pharmaceutical wastewater treated by ozone. Int Res J Environ Sci 2:21–25
Idris MA, Kolo BG, Garba ST, Ismail MA (2013) Physico-chemical analysis of pharmaceutical effluent and surface water of river Gorax in Minna, Niger State, Nigeria. Bull Env Pharmacol Life Sci 2:45–49
Ileri R, Sengil IA, Kulac S, Damar Y (2003) Treatment of mixed pharmaceutical industry and domestic wastewater by sequencing batch reactor. J Environ Sci Health A 38:2101–2111
Imran H (2005) Wastewater monitoring of pharmaceutical industry: treatment and reuse options. Electron J Environ Agric Food Chem 4:994–1004
Kansal A, Siddiqui NA, Gautam A (2011) Assessment of heavy metals and their interrelationships with some physicochemical parameters in ecoefficient rivers of Himalayan Region. Int J Environ Sci 2:440–450
Kar D, Sur P, Mandal SK, Saha T, Kole RK (2008) Assessment of heavy metal pollution in surface water. Int J Environ Sci Technol 5:119–124
Kaur J, Kaur S (2014) Seasonal variations in water quality index of Sirhind canal passing through Moga, Punjab, India. Int J Res Eng Tech 3:558–563
Kumar P, Bharti PK (2012) Effluent quality assessment of different drains in SIDCUL industrial area at Haridwar (Uttarakhand). Environ Conserv J 13:115–118
Lapara TM, Nakatsu CH, Pantea LM, Alleman JE (2002) Stability of the bacterial communities supported by a seven-stage biological process treating pharmaceutical wastewater as revealed by PCR-DGGE. Water Res 36:638–646
Lefebvre O, Shi X, Wu CH, Ng HY (2014) Biological treatment of pharmaceutical wastewater from the antibiotics industry. Water Sci Technol 69:855–861
Lokhande RS, Singare PU, Pimple DS (2011a) Study on physico-chemical parameters of wastewater effluents from Taloja Industrial Estate of Mumbai, India. Int J Ecosystem 1:1–9
Lokhande RS, Singare PU, Pimple DS (2011b) Toxicity study of heavy metals pollutants in waste water effluents samples collected from Taloja Industrial Estate of Mumbai, India. Resour Environ 1:13–19
Madukasi EI, Dai X, He C, Zhou J (2010) Potentials of phototrophic bacteria in treating pharmaceutical wastewater. Int J Environ Sci Technol 7:165–174
Mamo G, Gessesse A (2000) Immobilization of alkaliphic Bacillus sp. cells for xylanase production using batch and continuous culture. Appl Biochem Biotechnol 87:95–101
Mareddy AR (2017) Environmental impact assessment: theory and practice. BS Publications, London
Mayabhate SP, Gupta SK, Joshi SG (1988) Biological treatment of pharmaceutical wastewater. Water Air Soil Pollut 38:189–197
Modak DP, Singh KP, Ahmed S, Ray PK (1990) Trace metal ion in Ganga water system. Chemosphere 21:275–287
Mohammad P, Azarmidokht H, Fatollah M, Mahboubeh B (2006) Application of response surface methodology for optimization of important parameters in decolorizing treated distillery wastewater using Aspergillus fumigatus UB2.60. Int Biodeterior Biodegrad 57:195–199
Nadal M, Schuhmacher M, Domingo JL (2004) Metal pollution of soils and vegetation in an area with petrochemical industries. Sci Total Environ 321:59–69
Nandy T, Shastry S, Kaul SN (2002) Wastewater management in a cane molasses distillery involving bio resource recovery. J Environ Manag 65:25–38
Obasi AI, Amaeze NH, Osoko DD (2014) Microbiological and toxicological assessment of pharmaceutical wastewater from the Lagos megacity, Nigeria. Chin J Biol 2014:1–9
Oktem YA, Ince O, Sallis P, Donnelly T, Ince BK (2007) Anaerobic treatment of a chemical synthesis-based pharmaceutical wastewater in a hybrid upflow anaerobic sludge blanket reactor. Bioresour Technol 99(5):1089–1096
Oz N, Ince O, Ince B (2004) Effect of wastewater composition on methanogenic activity in an anaerobic reactor. J Environ Sci Health A 39:2029–2042
Patel H, Madamwar D (2000) Biomethanation of low pH petrochemical wastewater using up-flow fixed film anaerobic bioreactors. World J Microbiol Biotechnol 16:69–75
Patil PG, Kulkarni GS, Kore SV, Kore VS (2013) Aerobic sequencing batch reactor for wastewater treatment: a review. Int J Eng Res Technol 2:534–550
Prabha S, Selvapathy P (1997) Heavy metal pollution in Indian rivers. Indian J Environ Prot 17:641–649
Rajaram T, Das A (2008) Water pollution by industrial effluents in India: discharge scenarios and case for participatory ecosystem specific local regulation. Futures 40:56–69
Rajeshwari KV, Balakrishnan M, Kansal A, Lata K, Kishore VVN (2000) State-of art of anaerobic digestion technology for industrial wastewater treatment. Renew Sust Energ Rev 4:135–156
Ramola B, Singh A (2013) Heavy metal concentrations in pharmaceutical effluents of Industrial Area of Dehradun (Uttarakhand), India. Int J Environ Sci Res 2:140–145
Rana RS, Kandari V, Singh P, Singh R, Gupta S (2014a) A review on characterization and bioremediation of pharmaceutical industries wastewater: an Indian perspective. Appl Water Sci. https://doi.org/10.1007/s13201-014-0225-3
Rana RS, Singh P, Singh R, Gupta S (2014b) Assessment of physico-chemical pollutants in Pharmaceutical Industrial wastewater of Pharmacity, Selaqui, Dehradun. Int J Res Chem Environ 4:136–142
Rana RS, Kandari V, Singh P, Gupta S (2014c) Assessment of heavy metals in Pharmaceutical Industrial wastewater of Pharmacity, Selaqui, Dehradun, Uttarakhand, India. Anal Chem Lett 4:29–39
Rao AG, Naidu GV, Prasad KK, Rao NC, Mohan SV, Jetty A, Sharma PN (2004) Anaerobic treatment of wastewater with high suspended solids from a bulk drug industry using fixed film reactor (AFFR). Bioresour Technol 93:241–247
Rohit CK, Ponmurugan P (2013) Physico-chemical analysis of textile automobile and pharmaceutical industrial effluents. Int J Latest Res Sci Technol 2:115–117
Saleem M (2007) Pharmaceutical wastewater treatment: a physicochemical study. J Res (Sci) 18:125–134
Semwal N, Akolkar P (2006) Water quality assessment of sacred Himalayan rivers of Uttaranchal. Curr Sci 9:486–496
Seth R, Singh P, Mohan M, Singh R, Aswal RS (2013) Monitoring of phenolic compounds and surfactants in water of Ganga Canal, Haridwar (India). Appl Water Sci 3:717–720
Singare UP, Lokhande SR, Jagtap GA (2010a) Study of physico-chemical quality of the industrial wastewater effluent from Gove industrial area of Bhiwandi city of Maharashtra, India. Interdiscip Environ Rev 11:263–273
Singare UP, Lokhande SR, Jagtap GA (2010b) Water pollution by discharge effluents from Gove Industrial Area of Maharashtra, India: dispersion of heavy metals and their toxic effects. Int J Global Environ Issues 11:28–36
Singh SN, Srivastav G, Bhatt A (2012) Physicochemical determination of pollutants in wastewater in Dehradun. Curr World Environ 7:133–138
Sirtori C, Zapata A, Oller I, Gernjak W, Aguera A, Malato S (2009) Decontamination industrial pharmaceutical wastewater by combining solar photo-Fenton and biological treatment. Water Res 43:661–668
Spina F, Anastasi A, Prigione V, Tigini V, Varese GC (2012) Biological treatment of industrial wastewaters: a fungal approach. Chem Eng Trans 27:175–180
Sreekanth D, Sivaramakrishna D, Himabindu V, Anjaneyulu Y (2009) Thermophilic treatment of bulk drug pharmaceutical industrial wastewaters by using hybrid up flow anaerobic sludge blanket reactor. Bioresour Technol 100:2534–2539
Toloti AJ, Gergely F, Mizsey P (2011) Physicochemical treatment of pharmaceutical process wastewater: distillation and membrane processes. Chem Eng 55:59–67
US Environmental Protection Agency (2015) https://www.epa.gov/wqs-tech/final-rulemaking-update-national-water-quality-standards-regulation
Vanerkar AP, Satyanarayan S, Dharmadhikari DM (2013) Full scale treatment of herbal pharmaceutical industry wastewater. Int J Chem Phys Sci 2:52–62
Vuppala NVS, Suneetha C, Saritha V (2012) Study on treatment process of effluent in bulk drug industry. Int J Res Pharmaceut Biomed Sci 3:1095–1102
Wei X, Li B, Zhao S, Wang L, Zhang H, Li C, Wang S (2012) Mixed pharmaceutical wastewater treatment by integrated membrane-aerated biofilm reactor (MABR) system—a pilot-scale study. Bioresour Technol 122:189–195 www.docstoc.com
Xing ZP, Sun DZ, Yu XJ, Zou JL, Zhou W (2014) Treatment of antibiotic fermentation- based pharmaceutical wastewater using anaerobic and aerobic moving bed biofilm reactors combined with ozone/hydrogen peroxide process. Environ Prog Sustain Energy 33:170–177
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Gupta, S., Dobhal, R., Gupta, A., Rani, U., Kumar, V. (2018). Water Quality Assessment and Treatment of Pharmaceutical Industry Wastewater: A Case Study of Pharmacity Selaqui, Dehradun of Uttarakhand State, India. In: Kumar, V., Kumar, M., Prasad, R. (eds) Phytobiont and Ecosystem Restitution. Springer, Singapore. https://doi.org/10.1007/978-981-13-1187-1_18
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