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Which is the Most Reasonable Anti-aging Strategy: Meta-analysis

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Aging and Aging-Related Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1086))

Abstract

An organism’s lifespan is inevitably accompanied by the aging process, which involves functional decline, a steady increase of a plethora of chronic diseases, and ultimately death. Thus, it has been an ongoing dream of mankind to improve health span and extend the lifespan. In the last century, there is a great increase in the search for eternal youth and an insatiable appetite for methods which could turn back the clock. Survival curves are key components of lifespan experiments. Many interventions have been reported to extend the lifespan, including the administration of pharmaceuticals, calorie restriction, and genetic alteration. However, few studies have attempted to provide a comprehensive analysis of the mechanism by which these various methods function to extend lifespan. We recently collected survival curves from published papers and recovered data by fitting models. The analysis results highlight the overall advantage of calorie restriction and its mimetics in aging and demonstrate that hypoglycemic agents and antioxidants have a superior effect on lifespan extension via a pattern of global integrity compared to other medications. This review provides a scientific foundation for the discovery of effective anti-aging agents and the formulation of scientific anti-aging strategies.

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Acknowledgments

This work was financially supported by grants from the National Natural Science Foundation of China (81471396), the National Key R&D Program of China (2018YFD0400204), the Key International S&T Cooperation Program of China (2016YFE113700), and the European Union’s 2020 Research and Innovation Program (633589).

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Authors and Affiliations

  1. MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Yaru Liang

  2. School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Zhao Wang

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  1. Yaru Liang
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  2. Zhao Wang
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Correspondence to Zhao Wang .

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  1. School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Zhao Wang

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Liang, Y., Wang, Z. (2018). Which is the Most Reasonable Anti-aging Strategy: Meta-analysis. In: Wang, Z. (eds) Aging and Aging-Related Diseases. Advances in Experimental Medicine and Biology, vol 1086. Springer, Singapore. https://doi.org/10.1007/978-981-13-1117-8_17

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