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Novel Biomaterials for Regenerative Medicine pp 87–113Cite as

Novel Biomimetic Microphysiological Systems for Tissue Regeneration and Disease Modeling

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1077)

Abstract

Biomaterials engineered to closely mimic morphology, architecture, and nanofeatures of naturally occurring in vivo extracellular matrices (ECM) have gained much interest in regenerative medicine and in vitro biomimetic platforms. Similarly, microphysiological systems (MPS), such as lab-chip, have drummed up momentum for recapitulating precise biomechanical conditions to model the in vivo microtissue environment. However, porosity of in vivo scaffolds regulating barrier and interface functions is generally absent in lab-chip systems, or otherwise introduces considerable cost, complexity, and an unrealistic uniformity in pore geometry. We address this by integrating electrospun nanofibrous porous scaffolds in MPS to develop the lab-on-a-brane (LOB) MPS for more effectively modeling transport, air-liquid interface, and tumor progression and for personalized medicine applications.

Keywords

  • Nanomedicine
  • nanotechnology
  • electrohydrodynamic
  • atomization
  • electrospinning
  • tissue engineering
  • microphysiological systems
  • disease model

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Acknowledgements

In addition to elixir international® and the National Science Foundation (NSF EPS 1158862, DMR 1460392 REU), for their generous support, we thank P. Sethu, M.N. Saleh, S. Pillay, C.A. Monroe, U.K. Vaidya, M.L. Weaver, HW. Jun, G. Walcott, H. Budhwani, J.R. Richter, K.F. Goliwas, A. Gangrade, A.T. Wood, H. Zhang, and J. Rogers for their insight and expertise. We would also like to acknowledge UAB Comprehensive Cancer Center (CCC), UAB Scanning Electron Microscope Lab, and Research Machine Shop for use of facilities and equipment.

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Authors and Affiliations

  1. Departments of Radiation Oncology and Materials Science & Engineering, The University of Alabama at Birmingham, Birmingham, AL, USA

    Karim I. Budhwani

  2. Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, AL, USA

    Patsy G. Oliver & Donald J. Buchsbaum

  3. Department of Materials Science & Engineering, The University of Alabama at Birmingham, Birmingham, AL, USA

    Vinoy Thomas

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  1. Karim I. Budhwani
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  2. Patsy G. Oliver
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  3. Donald J. Buchsbaum
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  4. Vinoy Thomas
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Corresponding author

Correspondence to Vinoy Thomas .

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Editors and Affiliations

  1. The Catholic University of Korea, Seoul, Korea (Republic of)

    Prof. Heung Jae Chun

  2. Korea Institute of Science and Technology, Seoul, Korea (Republic of)

    Ph.D. Kwideok Park

  3. Korea Institute of Radiological and Medical Sciences, Seoul, Korea (Republic of)

    Prof. Chun-Ho Kim

  4. Chonbuk National University, Jeonju, Korea (Republic of)

    Prof. Gilson Khang

Abbreviations

Abbreviations

ASC

Adult stem cells

AACR

American Association for Cancer Research

CVD

Cardiovascular diseases

EC

Endothelial cells

ECM

Extracellular matrix (or matrices)

EHDA

Electrohydrodynamic atomization

ESC

Embryonic stem cells

FDA

Food and Drug Administration

FITC

Fluorescein isothiocyanate

HTS

High-throughput screening

HMSC

Human mesenchymal stem cells

iPSC

Induced pluripotent stem cells

LOB

Lab-on-a-brane

MSC

Mesenchymal stem cells

nHA

Nanohydroxyapatite

NIH

National Institutes of Health

NSC

Neural stem cells

NSF

National Science Foundation

NSPC

Neural stem/progenitor cells

pAA

Polyacrylamide

PCL

Poly(Ɛ-caprolactone)

PDMS

Polydimethyl siloxane

PET

Polyethylene terephthalate

PG

Proteoglycans

PLGA

Polylactide-co-glycolide

SC

Stem cells

SEM

Scanning electron microscopy

SMC

Smooth muscle cells

UV

Ultraviolet

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Budhwani, K.I., Oliver, P.G., Buchsbaum, D.J., Thomas, V. (2018). Novel Biomimetic Microphysiological Systems for Tissue Regeneration and Disease Modeling. In: Chun, H., Park, K., Kim, CH., Khang, G. (eds) Novel Biomaterials for Regenerative Medicine. Advances in Experimental Medicine and Biology, vol 1077. Springer, Singapore. https://doi.org/10.1007/978-981-13-0947-2_6

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