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Advanced Injectable Alternatives for Osteoarthritis

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Novel Biomaterials for Regenerative Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1077))

Abstract

Osteoarthritis (OA) is a common form of arthritis, which is characterized by progressive degradation of joint cartilage resulting in pain, joint stiffness, deformity and disability that is also recently related to an increased incidence of mortality. Inhibition of the extracellular matrix (ECM) production by chondrocytes and accumulation of catabolic mediators associated with matrix degradation are the cause of OA. Nonsurgical treatments for OA can be characterised as symptom-modifying or disease-modifying approaches. It’s estimated that 10% of the world population older than 60 years demonstrated symptoms of OA (Messier SP, Callahan LF, Beavers DP et al., BMC Musculoskelet Disord 18(1):91, 2017). A virtue of chondrocytes has a limited proliferation capability; nonsurgical OA therapies mostly include native cartilage extracellular component injections like hyaluronic acid, anti-inflammatory effected autologous cell implantations, platelet rich plasma injections and medicals like corticosteroids. Stem cells are searched to cure OA recently. Also nowadays we can develop injectable release systems, biocompatible hydrogels and micro/nano sized carriers to make these medicals more effective. In this review we cover injectable alternatives to modify the natural course of OA that gives a window for patients between conventional treatment methods and joint replacement surgery.

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Authors and Affiliations

  1. Department of Nanotechnology and Nanomedicine, Graduate School of Science and Engineering, Hacettepe University, Ankara, Turkey

    Şebnem Şahin

  2. Department of Chemical Engineering, Faculty of Engineering, Hacettepe University, Ankara, Turkey

    Süleyman Ali Tuncel

  3. Department of Chemical Engineering, Faculty of Engineering and Natural Sciences, Ankara Yildirim Beyazit University, Ankara, Turkey

    Kouroush Salimi

  4. Department of Histology and Embryology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

    Elif Bilgiç & Petek Korkusuz

  5. Department of Sports Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey

    Feza Korkusuz

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  1. Şebnem Şahin
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  2. Süleyman Ali Tuncel
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  3. Kouroush Salimi
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  4. Elif Bilgiç
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  5. Petek Korkusuz
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  6. Feza Korkusuz
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Editors and Affiliations

  1. The Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. Korea Institute of Science and Technology, Seoul, Korea (Republic of)

    Kwideok Park

  3. Korea Institute of Radiological and Medical Sciences, Seoul, Korea (Republic of)

    Chun-Ho Kim

  4. Chonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Şahin, Ş., Tuncel, S.A., Salimi, K., Bilgiç, E., Korkusuz, P., Korkusuz, F. (2018). Advanced Injectable Alternatives for Osteoarthritis. In: Chun, H., Park, K., Kim, CH., Khang, G. (eds) Novel Biomaterials for Regenerative Medicine. Advances in Experimental Medicine and Biology, vol 1077. Springer, Singapore. https://doi.org/10.1007/978-981-13-0947-2_11

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