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HIV Broadly Neutralizing Antibodies: VRC01 and Beyond

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1075)

Abstract

Developing an effective prophylaxis HIV-1 vaccine is likely to require the elicitation of broadly neutralizing antibodies (bnAbs). As the HIV-1 envelope (Env) glycoprotein – the sole target of bnAbs – has evolved multiple mechanisms to evade antibody neutralization, the processes for bnAb generation are highly selective and time-consuming. Benefiting from antibody isolation technologies of single B cell culturing and direct single B cell sorting and cloning, a new generation of monoclonal bnAbs has been isolated since 2009, exhibiting remarkable breadths and potencies, thus breaking through a nearly 20-year-long limit of four monoclonal bnAbs with moderate breadth and potency. The discovery of a long list of monoclonal bnAbs has provided in-depth understanding of the sites of vulnerability on the HIV-1 Env and the complexity of human B cell immunology to generate such responses, thus presenting both guidance and challenges to move the Env immunogen design effort forward.

Keywords

  • HIV-1
  • VRC01
  • Monoclonal antibody
  • Neutralization

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Fig. 3.1
Fig. 3.2

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Acknowledgments

Xueling Wu and her laboratory are funded by internal funds from the Aaron Diamond AIDS Research Center and by research grants R01AI114380 and R01AI122593 from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), USA.

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Wu, X. (2018). HIV Broadly Neutralizing Antibodies: VRC01 and Beyond. In: Zhang, L., Lewin, S. (eds) HIV Vaccines and Cure . Advances in Experimental Medicine and Biology, vol 1075. Springer, Singapore. https://doi.org/10.1007/978-981-13-0484-2_3

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