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Abstract

So far, few randomized trials are known for the role of folic acid or folate in depression. Folate added to antidepressant drug treatment offered limited evidence that folate has potential role in depression (Zhao et al. 2011). Some studies have reported utility of folic acid in treating depression (Watanabe et al. 2012) (Fig. 18.1).

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References

  • Alpert JE, Papakostas G, Mischoulon D, Worthington JJ, Petersen T, Mahal Y, et al. S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or non-response to selective serotonin reuptake inhibitors or venlafaxine. J Clin Psychopharmacol. 2004;24:661–4.

    Article  PubMed  CAS  Google Scholar 

  • Beckmann H, Ludolph E. DL-phenylalanine as an antidepressant. Open study (author’s transl). Arzneimittelforschung. 1978;28:1283–4.

    PubMed  CAS  Google Scholar 

  • Beckmann H, Strauss MA, Ludolph E. Dl-phenylalanine in depressed patients: an open study. J Neural Transm. 1977;41:123–34.

    Article  PubMed  CAS  Google Scholar 

  • Beckmann H, Athen D, Olteanu M, Zimmer R. DL-phenylalanine versus imipramine: a double-blind controlled study. Arch Psychiatr Nervenkr (1970). 1979;227:49–58.

    Article  CAS  Google Scholar 

  • Chavez M. SAMe: S-Adenosylmethionine. Am J Health Syst Pharm. 2000;57:119–23.

    PubMed  CAS  Google Scholar 

  • Delle CR, Pancheri P, Scapicchio P. Efficacy and tolerability of oral and intramuscular S-adenosyl-L- methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002;76:1172S–6.

    Article  Google Scholar 

  • Galizia I, Oldani L, Macritchie K, Amari E, Dougall D, Jones TN, Lam RW, Massei GJ, Yatham LN, Young AH. S-adenosyl methionine (SAMe) for depression in adults. Cochrane Database Syst Rev. 2016;10:CD011286.

    PubMed  Google Scholar 

  • Mischoulon D, Alpert JE, Arning E, Bottiglieri T, Fava M, Papakostas GI. Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. J Clin Psychiatry. 2012;73:843–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Soh NL, Walter G. Tryptophan and depression: can diet alone be the answer? Acta Neuropsychiatrica. 2011;1:3–11.

    Article  Google Scholar 

  • Watanabe H, Ishida S, Konno Y, Matsumoto M, Nomachi S, Masaki K, Okayama H, Nagai Y. Impact of dietary folate intake on depressive symptoms in young women of reproductive age. J Midwifery Womens Health. 2012;57:43–8.

    Article  PubMed  Google Scholar 

  • Zhao G, Ford ES, Li C, Greenlund KJ, Croft JB, Balluz LS. Use of folic acid and vitamin supplementation among adults with depression and anxiety: a cross-sectional, population-based survey. Nutr J. 2011;10:102.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Saroya, A.S., Singh, J. (2018). Neuropharmacology of Nutritional Supplements. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_18

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