Skip to main content
SpringerLink
Log in

Distribution and Translocation of Nanomaterials

  • Chapter
  • First Online:
Nanotoxicology in Caenorhabditis elegans

  • 376 Accesses

Abstract

Distribution and translocation of engineered nanomaterials (ENMs) is one of the crucial cellular contributors for the toxicity induction of ENMs. After exposure, the primary targeted organs of ENMs can be defined as the intestine and the epidermis, and the secondary targeted organs of ENMs contain at least the reproductive organs, such as the gonad and the spermatheca, and the neurons in nematodes. So far, the normally considered primary targeted organ for ENMs is the intestine in nematodes. In this chapter, we first introduce the techniques for the analysis on distribution and translocation of ENMs. Moreover, the distribution and translocation of different ENMs in the primary or the secondary targeted organs, as well as the patterns of transgenerational translocation of ENMs, and the underlying cellular, molecular, and chemical metabolisms for distribution and translocation of ENMs are systematically introduced.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Leung MC, Williams PL, Benedetto A, Au C, Helmcke KJ, Aschner M, Meyer JN (2008) Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci 106:5–28

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zhao Y-L, Wu Q-L, Li Y-P, Wang D-Y (2013) Translocation, transfer, and in vivo safety evaluation of engineered nanomaterials in the non-mammalian alternative toxicity assay model of nematode Caenorhabditis elegans. RSC Adv 3:5741–5757

    Article  CAS  Google Scholar 

  3. Wang D-Y (2016) Biological effects, translocation, and metabolism of quantum dots in nematode Caenorhabditis elegans. Toxicol Res 5:1003–1011

    Article  CAS  Google Scholar 

  4. Pluskota A, Horzowski E, Bossinger O, von Mikecz A (2009) In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence. PLoS One 4(8):e6622

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. McGhee JD (2007) The C. elegans intestine. WormBook. https://doi.org/10.1895/wormbook.1.133.1

  6. Chisholm AD, Hardin J (2005) Epidermal morphogenesis. WormBook. https://doi.org/10.1895/wormbook.1.35.1

  7. Yang J-N, Zhao Y-L, Wang Y-W, Wang H-F, Wang D-Y (2015) Toxicity evaluation and translocation of carboxyl functionalized graphene in Caenorhabditis elegans. Toxicol Res 4:1498–1510

    Article  CAS  Google Scholar 

  8. Meyer JN, Lord CA, Yang XY, Turner EA, Badireddy AR, Marinakos SM, Chilkoti A, Wiesner MR, Auffan M (2010) Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans. Aquat Toxicol 100:140–150

    Article  CAS  PubMed  Google Scholar 

  9. Lim SF, Riehn R, Ryu WS, Khanarian N, Tung C, Tank D, Austin RH (2006) In vivo and scanning electron microscopy imaging of upconverting nanophosphors in Caenorhabditis elegans. Nano Lett 6(2):169–174

    Article  CAS  PubMed  Google Scholar 

  10. Chen J, Guo C, Wang M, Huang L, Wang L, Mi C, Li J, Fang X, Mao C, Xu S (2011) Controllable synthesis of NaYF4: Yb, Er upconversion nanophosphors and their application to in vivo imaging of Caenorhabditis elegans. J Mater Chem 21(8):2632

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Zhou J, Yang Z, Dong W, Tang R, Sun L, Chun-Hua Yan C (2011) Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals. Biomaterials 32:9059–9067

    Article  CAS  PubMed  Google Scholar 

  12. Qu Y, Li W, Zhou Y, Liu X, Zhang L, Wang L, Li Y, Iida A, Tang Z, Zhao Y, Chai Z, Chen C (2011) Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism. Nano Lett 11:3174–3183

    Article  CAS  PubMed  Google Scholar 

  13. Zhang L, Xia J, Zhao Q, Liu L, Zhang Z (2010) Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. Small 6:537–544

    Article  CAS  PubMed  Google Scholar 

  14. Cranfield CG, Dawe A, Karloukovski V, Dunin-Borkowski RE, de Pomerai D, Dobson J (2004) Biogenic magnetite in the nematode Caenorhabditis elegans. Proc R Soc Lond B 271(Suppl):S436–S439

    Article  Google Scholar 

  15. Zhao Y-L, Wu Q-L, Tang M, Wang D-Y (2014) The in vivo underlying mechanism for recovery response formation in nano-titanium dioxide exposed Caenorhabditis elegans after transfer to the normal condition. Nanomedicine 10:89–98

    Article  CAS  PubMed  Google Scholar 

  16. Wu Q-L, Zhao Y-L, Li Y-P, Wang D-Y (2014) Susceptible genes regulate the adverse effects of TiO2-NPs at predicted environmental relevant concentrations on nematode Caenorhabditis elegans. Nanomedicine 10:1263–1271

    Article  CAS  PubMed  Google Scholar 

  17. Gao Y, Liu N, Chen C, Luo Y, Li Y, Zhang Z, Zhao Y, Zhao B, Iida A, Chai Z (2008) Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence. J Anal At Spectrom 23:1121–1124

    Article  CAS  Google Scholar 

  18. Zanni E, De Bellis G, Bracciale MP, Broggi A, Santarelli ML, Sarto MS, Palleschi C, Uccelletti D (2012) Graphite nanoplatelets and Caenorhabditis elegans: insights from an in vivo model. Nano Lett 12:2740–2744

    Article  CAS  PubMed  Google Scholar 

  19. Wu Q-L, Yin L, Li X, Tang M, Zhang T, Wang D-Y (2013) Contributions of altered permeability of intestinal barrier and defecation behavior to toxicity formation from graphene oxide in nematode Caenorhabditis elegans. Nanoscale 5(20):9934–9943

    Article  CAS  PubMed  Google Scholar 

  20. Wu Q-L, Zhao Y-L, Fang J-P, Wang D-Y (2014) Immune response is required for the control of in vivo translocation and chronic toxicity of graphene oxide. Nanoscale 6:5894–5906

    Article  CAS  Google Scholar 

  21. Nouara A, Wu Q-L, Li Y-X, Tang M, Wang H-F, Zhao Y-L, Wang D-Y (2013) Carboxylic acid functionalization prevents the translocation of multi-walled carbon nanotubes at predicted environmental relevant concentrations into targeted organs of nematode Caenorhabditis elegans. Nanoscale 5:6088–6096

    Article  CAS  PubMed  Google Scholar 

  22. Wu Q-L, Li Y-X, Li Y-P, Zhao Y-L, Ge L, Wang H-F, Wang D-Y (2013) Crucial role of biological barrier at the primary targeted organs in controlling translocation and toxicity of multi-walled carbon nanotubes in nematode Caenorhabditis elegans. Nanoscale 5:11166–11178

    Article  CAS  PubMed  Google Scholar 

  23. Zhao Y-L, Wang X, Wu Q-L, Li Y-P, Wang D-Y (2015) Translocation and neurotoxicity of CdTe quantum dots in RMEs motor neurons in nematode Caenorhabditis elegans. J Hazard Mater 283:480–489

    Article  CAS  PubMed  Google Scholar 

  24. Zhao Y-L, Wang X, Wu Q-L, Li Y-P, Tang M, Wang D-Y (2015) Quantum dots exposure alters both development and function of D-type GABAergic motor neurons in nematode Caenorhabditis elegans. Toxicol Res 4:399–408

    Article  CAS  Google Scholar 

  25. Zhao Y-L, Liu Q, Shakoor S, Gong JR, Wang D-Y (2015) Transgenerational safe property of nitrogen-doped graphene quantum dots and the underlying cellular mechanism in Caenorhabditis elegans. Toxicol Res 4:270–280

    Article  CAS  Google Scholar 

  26. Liu Z-F, Zhou X-F, Wu Q-L, Zhao Y-L, Wang D-Y (2015) Crucial role of intestinal barrier in the formation of transgenerational toxicity in quantum dots exposed nematodes Caenorhabditis elegans. RSC Adv 5:94257–94266

    Article  CAS  Google Scholar 

  27. Li Y-X, Wang W, Wu Q-L, Li Y-P, Tang M, Ye B-P, Wang D-Y (2012) Molecular control of TiO2-NPs toxicity formation at predicted environmental relevant concentrations by Mn-SODs proteins. PLoS One 7(9):e44688

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Wu Q-L, Zhao Y-L, Li Y-P, Wang D-Y (2014) Molecular signals regulating translocation and toxicity of graphene oxide in nematode Caenorhabditis elegans. Nanoscale 6:11204–11212

    Article  CAS  PubMed  Google Scholar 

  29. Zhi L-T, Ren M-X, Qu M, Zhang H-Y, Wang D-Y (2016) Wnt ligands differentially regulate toxicity and translocation of graphene oxide through different mechanisms in Caenorhabditis elegans. Sci Rep 6:39261

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Maurer LL, Yang X, Schindler AJ, Taggart RK, Jiang C, Hsu-Kim H, Sherwood DR, Meyer JN (2015) Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans. Nanotoxicology 11:1–5

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical School, Southeast University, Nanjing, Jiangsu, China

    Dayong Wang

Authors
  1. Dayong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Wang, D. (2018). Distribution and Translocation of Nanomaterials. In: Nanotoxicology in Caenorhabditis elegans. Springer, Singapore. https://doi.org/10.1007/978-981-13-0233-6_8

Download citation

Publish with us

Policies and ethics

Search

Navigation