Abstract
The unique physicochemical properties of different engineered nanomaterials (ENMs) not only allow their potential industrial or medical applications at different aspects but also lead to different biological effects on organisms and interactions with targeted cells or tissues in organisms. The well-described cellular, developmental, molecular, and genetic backgrounds and the sensitivity to toxicity of environmental toxicants or stresses of Caenorhabditis elegans provide a powerful in vivo model system to determine the roles of physicochemical properties of ENMs in the toxicity formation of different ENMs in organisms. We here systematically introduce the important roles of different physicochemical properties of ENMs, mainly including size, surface charge, shape, surface groups, and impurity, in the toxicity formation of ENMs, which provides the underlying important chemical basis for the observed toxicity of ENMs in nematodes.
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Wang, D. (2018). Physicochemical Basis for Nanotoxicity Formation. In: Nanotoxicology in Caenorhabditis elegans. Springer, Singapore. https://doi.org/10.1007/978-981-13-0233-6_5
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DOI: https://doi.org/10.1007/978-981-13-0233-6_5
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