Abstract
Polydrug dependence shows an increasing trend in prevalence among addicts. It is a result of an addict abusing another drug to mask the undesirable effects of another drug. However, this could lead to adverse neuroadaptations. Therefore, we aim to investigate the effects of low-dose methamphetamine use in morphine-dependent subjects during reinstatement following treatment (0.3 mg/kg buprenorphine/1.0 mg/kg naltrexone combination) in mice. Using tail withdrawal assay, the involvement of opioid receptors was investigated at 1.0–5.0 mg/kg methamphetamine, i.p. at 52 °C. The results showed that analgesic activity was only detected at the highest dose given, which was successfully blocked with 1.0 mg/kg naltrexone, i.p. (p < 0.001, n = 6). Next, naïve mice were randomly divided into three groups (n ≥ 12) where the mice were made dependent (p < 0.01) to morphine (7.5 mg/kg, i.p.), methamphetamine (1.0 mg/kg, i.p.) or morphine/methamphetamine combination (7.5 and 1.0 mg/kg respectively). Although relapse was successfully attenuated with non-significant difference compared to baseline, it was found that 6 out of 13 mice showed sign of opioid receptor sensitization through stereotype and Straub’s tail response (>45°) which was not detected in the morphine- and methamphetamine-dependent groups during pre-screening of treatment drug. This suggests that although methamphetamine has little apparent withdrawal symptoms, it has the ability to sensitize the opioid receptors even at ‘inactive’ doses when it is used concurrently with morphine.
Keywords
- Methamphetamine
- Opioid receptor
- Polydrug
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Bailey CP, Husbands SM (2014) Novel approaches for the treatment of psychostimulant and opioid abuse—focus on opioid receptor-based therapies. Expert Opin Drug Discov 9(11):1333–1344
Carruth B, Wallen J (2014) Addiction in human development: development perspectives on addiction discovery. Routledge, New York
Chiu C, Ma T, Ho IK (2006) Methamphetamine-induced behavioural sensitization in mice: alterations in μ-opioid receptor. J Biomed Sci 13:797–811
Christoph T, Kogel B, Schiene K, Meen M, De Vry J, Fredrichs E (2005) Broad analgesic profile of buprenorphine in rodent models of acute nad chronic pain. Eur J Pharmacol 507(1–3):87–98
Cordery SF, Taverner A, Ridzwan IE, Guy RH, Delgado-Charro MB, Husbands SM, Bailey CP (2014) A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addict Biol 19(4):575–586
Duvauchelle CL, Sapoznik T, Kornetsky C (1998) The synergestic effects of combining cocaine and heroine (“speedball”) using a progressive-ratio schedule of drug reinforcement. Pharmacol Biochem Behav 61(3):297–302
Feltenstein MW, See RE (2008) The neurocircuitry of addiction: an overview. Br J Pharmacol 154(2):261–274
Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Tanaka K, Nishiyama N, Takemuraa M (2012) Straub tail reaction in mice treated with σ1 receptor antagonist in combination with methamphetamine. Brain Res 1482:40–46
Lan K-C, Chang AC, Liu S-H, Ho IK, Lin-Shiau S-Y (2009) Enhancing effects of morphine on methamphetamine-induced reinforcing behaviour and its association with dopamine release and metabolism in mice. J Neurochem 109(2):382–392
Le Bars D, Gozariu M, Cadden SW (2001) Animal models of nociception. Pharmacol Rev 53(4):597–652
Leri F, Bruneau J, Stewart J (2003) Understanding polydrug use: review on heroine and cocaine co-use. Addiction 98(1):7–22
Lingford-Hughes AR, Welch S, Peters L, Nutt DJ (2012) BAP updated guidelines: evidence based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP. J Psychopharmacol 26:899–952
McCann DJ (2008) Potential of buprenorphine/naltrexone in treating polydrug addiction and co-occurring psychiatric disorders. Clin Pharmacol Ther 83(4):627–630
National Research Council of The National Academies (2011) Guide for the care and use of laboratory animals. https://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals.pdf Accessed 5 Dec 2016
Redila VA, Chavkin C (2008) Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology 200(1):59–70
Rothman RB, Gorelick DA, Heishman SJ, Eichmiller PR, Hill BH, Norbeck J, Liberto JG (2000) An open-label study of a functional kappa antagonist in the treatment of opioid dependence. J Subst Abuse Treat 18:277–281
Rutten K, De Vry J, Bruckmann W, Tzschentke TM (2010) Effects of the NOP receptor agonist Ro65-6570 on the acquisition of opiate- and psychostimulant-induced conditioned place preference in rats. Eur J Pharmacol 645(1–3):119–126
Shariatirad S, Maarefvand M, Ekhtiari S (2013) Methamphetamine use and methadone maintenance treatment: an emerging problem in the drug addiction treatment network in Iran. Int J Drug Policy 24(6):115–116
Taylor SB, Lewis CR, Olive MF (2013) The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in human. Subst Abuse Rehabil 4:29–43
Zarrindast MR, Ghadimi M, Ramezani-Tehrani M, Sahebgharani M (2006) Effect of gaba receptor agonists or antagonists on morphine-induced Straub tail in mice. Int J Neurosci 116:963–973
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This research work is funded by Ministry of Higher Education (MOHE, RAGS12-025-0025).
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Ridzwan, I.E. et al. (2018). Low-Dose Methamphetamine Addiction Induced Opioid Receptor Sensitization in Polydrug-Dependent Mice. In: Yacob, N., Mohd Noor, N., Mohd Yunus, N., Lob Yussof, R., Zakaria, S. (eds) Regional Conference on Science, Technology and Social Sciences (RCSTSS 2016) . Springer, Singapore. https://doi.org/10.1007/978-981-13-0074-5_59
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DOI: https://doi.org/10.1007/978-981-13-0074-5_59
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